Immunomodulation properties of mesenchymal stem cells have attracted tremendous attention that eventually could regress liver fibrosis process.The study aims to demonstrate the immunomodulation activities Umbilical cord-derived Mesenchymal (UC-MSCs) affecting interleukin-10 (IL-10) and hyaluronic acid (HA) secretion post intraperitoneal injection CCl4, potent hepatotoxin, induced among experimental rats.There were 18 Sprague-Dawley (SD) rats divided into three treatment groups (G1 sham...

Helicobacter pylori vacA and cagA genes are associated with higher virulence. Vascular Endothelial Growth Factor (VEGF) is one important marker for neo-angiogenesis.The purpose of this study was to investigate the relationship between VEGF serum levels in H. infection.A cross-sectional done on eighty patients that consecutive admitted endoscopy unit. The diagnosis infection based rapid urease test. Serum samples were obtained determine circulating level. Polymerase chain reaction examine...

Coronary artery disease (CAD) remains a significant global health concern with considerable high morbidity and mortality its development is influenced by various genetic environmental factors. Proprotein convertase subtilisin/kexin type 9 (PCSK9) vital regulator of low-density lipoprotein receptor (LDLR) metabolism, directly impacting serum cholesterol levels. However, role in CAD not fully understood. The aim this study was to assess the association between level PCSK9 coronary lesion...

<p><strong>Aim <br /></strong>To investigate the effect of umbilical cord-derived mesenchymal stem cells (UC-MSCs) administration among liver<br />fibrosis experimental rat model via regulation angiotensin II type 1 receptor (AT1R) and platelet-derived growth factor-β (PDGF-β) due to their therapeutic potential replace liver transplantation for advanced fibrosis. Yet mechanism action has been...

Liver cirrhosis and the child-Turcotte-Pugh (CTP) score are inseparable entities in liver disease. CTP is largely known as mortality prognosis predictor. Nevertheless, ferritin emerges a simple biomarker related to prognosis. The study aimed determine whether there was significant correlation between serum levels score.The analysed 54 decompensated cirrhotic patients including 17 females 37 males May 2016 2017 at Haji Adam Malik General Hospital, Medan, Indonesia. Ferritin were, then,...

The main pathogenesis of gastritis is inflammation that closely related to free radicals. Malondialdehyde (MDA) a radical biomarker and found increase in patients. However, these studies are generally performed on experimental animals as well MDA examination gastric mucosa. This study aim was determine the association degrees (degree lymphocyte infiltration, neutrophil activity, atrophy, intestinal metaplasia) with plasma level. A cross-sectional 80 consecutive patients who came an...

Background: The prevalence of obesity among the population has risen dramatically due to a sedentary lifestyle. Obesity is risk factor for incidence non-alcoholic fatty liver disease (NAFLD) and NAFLD rises 90% in obese. clinically silent that become one most common causes worldwide also multiple extrahepatic complications or comorbidities. This study aims find association between Body mass index (BMI) NAFLD. Method: analytic with cross-sectional design was conducted on 3rd July 2022 Boho...

Background: Septic arthritis is an infectious disease that severely damages the joints with clinical manifestations such as swelling, erythema and warmth of affected joint. The most common cause this result hematogenous spread microorganisms. Some risk factors include injection drug use, prosthetic skin infection. incidence septic 5 to 8 per 100,000 population year 5-10% mortality rate, therefore preventive behavior needed minimize arthritis. Methods: This study observational analytic a...

Introduction: Hepatitis B virus (HBV) infection remains a global health concern, with significant number of morbidity and mortality. Tenofovir disoproxil fumarate (TDF) has emerged as first-line treatment for chronic HBV infection, however, its safety efficacy in Indonesian populations understudied. In this study, we aim to evaluate the TDF treatment. Methods: This cross-sectional study evaluated association between period duration corresponding response patients. Data were collected through...

Introduction: The MPV/Lymphocyte Ratio is a simple inflammatory parameter that can be obtained from complete blood count. Hepatitis patients with liver cirrhosis have higher MPV causing thrombopoietin to decrease so the platelet count decreases. response cause in number of lymphocytes and closely related poor prognosis hepatitis B virus. This study aims examine differences ratio chronic without cirrhosis. Methods: samples for this was who met he inclusion criteria. research carried out by...

Portal Hypertensive Gastropathy (PHG) occurs as a complication of cirrhotic or non-cirrhotic portal hypertension. The association between the severity hypertensive gastropathy and hepatic function, assessed by Child-Pugh score in patients with liver cirrhosis are poorly defined. We evaluated PHG cirrhosis. Adults admitted at Adam Malik Hospital Medan during January 2016-December 2016, were included this study. Endoscopic grade, assessed. A total 49 enrolled. Majority cases due to chronic...

The staging can be used as one of the prognostic factors providing a clinical picture patient in future colorectal cancer patient. In addition, carcinoembryonic antigen (CEA) tumor markers determine commonly diagnosis and prognosis cancer. Objective: aims study was to investigate relationship serum levels patients. Methods. This an analytical with cross-sectional design. sample patients at H. Adam Malik General Hospital, Medan from January 2016 December 2018. As many 52 subject who met...

Background: Helicobacter pylori is the most common cause of chronic gastritis in world, meanwhile caused by non-steroidal anti-inflammatory drugs (NSAIDs) encountered type gastritis.Increased free radicals can damage gastric mucous. Tissue due to be examined measuring malondialdehyde compound. There are many studies thatproves increased gastritis, but those commonly done animal experimentation and examination mucous.Method: This a cross-sectional study 40 dyspepsia patients who came...

Background: Gastrointestinal (GI) and hepatobiliary disorders are the most common complaints in patients with HIV/AIDS disease. These fundamental problems have not yet been addressed remains a rewarding area for research. Data about scarce, especially Indonesia. This study was aimed to identify gastrointestinal who were hospitalized Adam Malik Hospital, Medan.Method: A descriptive conducted based on medical records data from non-ambulatory had GI Internal Medicine wards of Hospital,Medan...

Background: Fatty liver is a broad term for condition in which there an increase triglyceride level hepatocyte. In Indonesia not much research about this condition. major health problem West countries, and slowly increasing Asian countries. For many individual with fatty liver, have no specific complaint or can symptoms at all. This aim of study to analyzed the relationship between images on abdominal CT scans dyslipidemia.
 Methods: observational analytic case – control type knowing...

This study aims to see differences in pentraxin 3 levels chronic hepatitis B sufferers with cirrosis and without cirrosis. The method uses cross sectional consecutive sampling. results of this found a significant difference between the average value Pentraxin Hepatitis patients liver cirrhosis group compared (p<0.001). There was Chronic (p<0.001) where were higher cirrhosis. In conclusion, can be used as an alternative marker assess development patients.
 
 Keywords: B, Liver...

Introduction: Helicobacter pylori (H. pylori) is a spiral-shaped, anaerobic, and gram-negative pathogenic bacteria found in the gastric mucosa that causes chronic gastritis cancer. One of most studied H. virulence factors CagA protein which positive anti-CagA antibodies increase risk malignancy stomach. This research was aimed to determine correlations between antibody serum premalignant lesions patients. Method: cross-sectional analytic research. The sample this study were patients...