A5101912530- Cardiac Structural Anomalies and Repair
- Sinusitis and nasal conditions
- Cardiac Valve Diseases and Treatments
- Allergic Rhinitis and Sensitization
- Hearing, Cochlea, Tinnitus, Genetics
- Cardiovascular Effects of Exercise
- Transplantation: Methods and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital heart defects research
- Respiratory Support and Mechanisms
- Cardiac tumors and thrombi
- Food Allergy and Anaphylaxis Research
- Drug Transport and Resistance Mechanisms
- Asthma and respiratory diseases
- Metastasis and carcinoma case studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Renal Transplantation Outcomes and Treatments
- Cardiac Imaging and Diagnostics
- Air Quality Monitoring and Forecasting
- Phytochemistry and Bioactive Compounds
- Endometriosis Research and Treatment
- Multiple and Secondary Primary Cancers
- Cancer and biochemical research
- Otitis Media and Relapsing Polychondritis
- Phosphodiesterase function and regulation
Leeds Teaching Hospitals NHS Trust
2022-2023
Papworth Hospital
2016-2017
University of Siena
1988-2013
Telethon Institute Of Genetics And Medicine
2013
Papworth Hospital NHS Foundation Trust
2013
IRCCS Materno Infantile Burlo Garofolo
2008
University of Trieste
2008
University of Verona
2007-2008
University of Naples Federico II
2003-2004
Lofarma (Italy)
2000
Variation in the bitter-taste receptor gene, TAS2R38 confers ability to taste 6-n-propylthiouracil (PROP). The objective of this study was relate haplotypes and PROP-tasting phenotypes adiposity a genetically isolated population. We hypothesized that nontaster phenotype would be associated with higher BMI waist circumference (WC) females, dietary restraint mediate relationship.Participants were 540 healthy inhabitants village Carlantino southern Italy who 15-89 years age at time study....
Background: The major allergens in fish are parvalbumins. Important immunoglobulin (Ig)E cross‐recognition of parvalbumins from different species has been shown. Recently frog parvalbumin α found to be responsible for a case IgE‐mediated anaphylaxis triggered by the ingestion meat. aim this study was investigate whether IgE antibodies allergic persons cross‐react with and appreciate its clinical relevance. Methods: sera 15 patients one patient were tested IgE‐immunoblotting against muscle...
During the production of some adeno-associated virus (AAV) serotypes, a large amount vectors is found in medium producing cells. For their purification, previous protocols used tangential flow filtration (TFF) followed by iodixanol gradient centrifugation. Taking advantage higher purity than cell-derived material as source AAV, we tested simple method that combines culture volumes containing AAV from cell stacks with clarification+TFF without further time-consuming and nonscalable To test...
Type 2 diabetes (T2D) is associated with an increased risk of left ventricular dysfunction after aortic valve replacement (AVR) in patients severe stenosis (AS). Persistent impairments myocardial energetics and blood flow (MBF) may underpin this observation. Using phosphorus magnetic resonance spectroscopy cardiovascular resonance, study tested the hypothesis that AS T2D (AS-T2D) would have impaired as reflected by phosphocreatine to ATP ratio (PCr/ATP) vasodilator stress MBF compared...
The effect of freeze-dried red wine (FDRW) on cardiac function and electrocardiogram (ECG) in Langendorff-isolated rat hearts was investigated. FDRW significantly decreased left ventricular pressure coronary perfusion pressure, the latter being dependent activation both phosphatidylinositol 3-kinase eNOS. did not affect QRS QT interval ECG, although at 56 μg gallic acid equivalents/mL, it prolonged PQ induced a second-degree atrioventricular block 3 out 6 hearts. This is first study...
Background An intra-cardiac abscess is a serious complication of both native (NV-IE) and prosthetic valve infective endocarditis (PV-IE). Despite being an accepted indication for surgery, controversies remain regarding the optimal timing type operation. We aimed to report outcomes patients managed abscesses over more than decade. Methods Patients aged ≥18 years between 1 January 2005 31 December 2017 were identified from prospectively collected IE database. The primary outcome was 30-day...
Abstract The vasorelaxing effect of isolates (compounds 1, 2, 3, and 4 (homoisoflavanones), compound 5 (sesquiterpenoid), compounds 6 7 (bufadienolides)) from the South African Hyacinthaceae has been assessed using rat aortic ring preparations. Compounds inhibited tonic contraction induced by both 60 mm K+ (K60) phenylephrine, 3 being most potent. 5, 6, caused a modest concentration-dependent relaxation, whereas 1 was ineffective. Under K25- or K60-induced depolarization, displayed...
Abstract Background Myxomata are rare, benign, primary tumours of the heart which can present with a variety symptoms depending on size, location, and mobility. Here, we report case enormous right atrial myxoma, obliterating ventricular cavities presenting failure. Case summary A 66-year-old Caucasian female presented to care failure was found have elevated N-terminal pro B-type natriuretic peptide 2829 ng/L (normal value <125 ng/L). The patient referred for urgent evaluation...
Starting from the observation that edema, vessel dilatation, and inflammatory cells infiltration are histopathological elements characteristic of nasal polyposis, authors have carried out a study on group patients suffering relapsing polyposis. The efficacy furosemide for prevention relapses polyposis in 4 year follow up has been pointed out. This diuretic given by inhalation proved to be able protect mucosa against provocation with ultrasonic nebulized distilled water prevent recurrence or...
We describe a case of hemolytic anemia and proximal anastomotic site stenosis following emergency repair Type A aortic dissection. This rare complication led to reoperation correct the iatrogenic cure consequent hemolysis. "sandwich" technique (with two Teflon strips on outside inside wall) was used in initial reinforce suture line prevent bleeding from anastomoses. At time reoperation, inner strip at anastomosis found have inverted into lumen, as suggested by preoperative magnetic resonance...
Research has been carried out in the town area of Milan on 275 subjects. For each patient following data have measured: ventilatory profile, aspecific bronchial reactivity, arterial concentration CO and acid-base balance. The results obtained divided into four groups, according to level SO2 residence subjects, who also studied with reference habit smoking. shown (1) an alteration function, decrease oxygen tension blood all (2) Increase irritability found these rates higher than those...
The development of inhibitors Tumor Necrosis Factor (TNF)α ro-inflammatory cytokine playing a pivotal role in chronic inflammatory diseases, represents milestone the therapy several rheumatic diseases. Currently, three TNFα -blo drugs are available for clinical use diseases: infliximab, etanercept and adalimumab. These rapidly reduce disease activity probably change poor outcome by preventing bone erosions, joint deformity disability. Although these have proved to be effective well tolerated...