A5064431855- Antifungal resistance and susceptibility
- Retinal Development and Disorders
- Fungal Infections and Studies
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- interferon and immune responses
- Neuroscience and Neuropharmacology Research
- Protein Tyrosine Phosphatases
- Adenosine and Purinergic Signaling
- Infectious Diseases and Mycology
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
Rutgers Health
2014-2020
Rutgers Sexual and Reproductive Health and Rights
2020
Rutgers New Jersey Medical School
2017
Rutgers, The State University of New Jersey
2014-2017
Retinal detachment disrupts the rod-bipolar synapse in outer plexiform layer by retraction of rod axons. We showed that breakage is due to RhoA activation whereas inhibition Rho kinase (ROCK), using Y27632, reduces synaptic damage. test whether ROCK inhibitor fasudil, used for other clinical applications, can prevent injury after detachment.Detachments were made pigs subretinal injection balanced salt solution (BSS) or fasudil (1, 10 mM). In some animals, was injected intravitreally...
The protracted diagnostic period and variable disease presentation not only complicate diagnosing SLE but also the epidemiologic study of it.Coupled with remitting relapsing nature challenges in managing it, clinical research lupus requires careful attention to design, control selection, temporality, many often overlooked issues analysis phase.Between "big data" impressive advances basic sciences, it is tempting either oversimplify methods take advantage or overcomplicate because problem...
Abstract Despite significant research efforts, breast cancer is still the most common malignancy in women and cause of death worldwide. A major challenge treatment disease heterogeneity that contributed by many factors including intrinsic cell factors, microenvironment, angiogenesis tumor-specific immune responses. Interferon regulatory factor 5 (IRF5) a transcription controls inflammatory Analysis over 3,000 human tissues revealed high expression IRF5 correlates with increased survival...
Abstract Type I (IFN-α/β) and III (IFN-λ) interferons are important mediators of antiviral immunity but whether they required for antifungal defense is unclear. We report that mice defective in and/or IFN receptor expression highly susceptible to infection with the opportunistic human fungal pathogen Aspergillus fumigatus (Af). (IFNAR) (IFNLR1) on hematopoietic cells was while their non-hematopoietic dispensable. Consistently, gene-specific deletion IFNLR1 or STAT-1 granulocytes were Af....