A5075287925- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Sarcoidosis and Beryllium Toxicity Research
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genomics and Chromatin Dynamics
- Glycosylation and Glycoproteins Research
- Molecular Biology Techniques and Applications
- RNA regulation and disease
- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- Carcinogens and Genotoxicity Assessment
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Nanoplatforms for cancer theranostics
Qilu Hospital of Shandong University
2020-2024
Second Affiliated Hospital of Jilin University
2022-2024
Southeast University
2023
Taian City Central Hospital
2020
Abstract Background Long non-coding RNAs (lncRNAs) are increasingly recognized as the crucial mediators in regulation of ferroptosis and iron metabolism. A systematic understanding iron-metabolism related lncRNAs (FIRLs) lung adenocarcinoma (LUAD) is essential for new diagnostic therapeutic strategies. Methods FIRLs were obtained through Pearson correlation analysis between genes all lncRNAs. Univariate multivariate Cox regression used to identify optimal prognostic Next, a novel signature...
The tumor microenvironment (TME) plays an important role in cancer development; however, its implications lung squamous cell carcinoma (LUSC) and pan-cancer have been poorly understood.
Immune-related genes (IRGs) play considerable roles in tumor immune microenvironment (IME). This research aimed to discover the differentially expressed immune-related (DEIRGs) based on Cox predictive model predict survival for lung squamous cell carcinoma (LUSC) through bioinformatics analysis. First of all, (DEGs) were acquired The Cancer Genome Atlas (TCGA) using limma R package, DEIRGs obtained from ImmPort database, whereas transcription factors (DETFs) Cistrome database. Thereafter, a...
Background: In recent years, LncRNA acts as a member of competing endogenous RNA (ceRNA), playing an important role in drug resistance lung cancer. The aim this study was to identify potential biomarkers about cisplatin resistant cancer cells using comprehensive ceRNA network. Methods: GSE6410 (GPL-201) analyzed gene expression changes A549 NSCLC cells. GSE43249 (GPL-14613) included noncoding profiling derived from the GEO2R, online analysis tool, differentially expressed mRNAs and miRNAs...
Background and aim:Competing endogenous RNA (ceRNA) is believed to play vital roles in tumorigenesis.The goal of this study was screen prognostic biomarkers lung adenocarcinoma (LUAD).Methods: Common differentially expressed genes (DEGs) were collected from Gene Expression Omnibus (GEO) databases The Cancer Genome Atlas (TCGA) using GEO2R "limma" package R, respectively.Overlapping DEGs conducted enrichment functions protein-protein interaction (PPI) network discover significant candidate...
Abnormal glycolysis is one of the hallmarks cancer and plays an important role in its development.This study was devoted to identify related genes as prognostic biomarkers for non-small cell lung (NSCLC).The mRNA expression profile clinical follow-up data were obtained using The Cancer Genome Atlas (TCGA) database.The validation set by bootstrap method random repeated sampling.A total 200 glycolysis-related from Gene Set Enrichment Analysis (GSEA) 46 significantly associated with overall...
The pathogenesis of sarcoidosis, which involves several systems, is unclear, and its pathological type non-caseating epithelioid granulomas. tRNA-derived small RNA (tsRNA) a novel class short non-coding RNAs with potential regulatory functions. However, whether tsRNA contributes to sarcoidosis remains unclear.Deep sequencing technology was used identify alterations in relative abundance profiles between patients healthy controls quantitative real-time polymerase chain reaction (qRT-PCR)...
Abstract Background: Tumor microenvironment (TME) plays a significant role in the development of cancer. However, roles TME lung squamous cell carcinoma (LUSC) are not well studied. In our study, we aimed to identify differentially expressed tumor microenvironment-related genes as biomarker for predicting prognosis LUSC. Methods: We combined The Cancer Genome Atlas (TCGA) and Estimation Stromal Immune cells Malignant tissue using Expression data (ESTIMATE) datasets identified...
Abstract Background: In recent years, LncRNA acts as a member of competing endogenous RNA (ceRNA), playing an important role in drug resistance lung cancer. The aim this study was to identify potential biomarkers about cisplatin resistant cancer cells using comprehensive ceRNA network. Methods: GSE6410 (GPL-201) analyzed gene expression changes cispaltin A549 NSCLC cells. GSE43249 (GPL-14613) included noncoding profiling derived from the GEO2R, online analysis tool, differentially expressed...
Abstract Background In recent years, LncRNA acts as a member of competing endogenous RNA (ceRNA), playing an important role in drug resistance lung cancer. The aim this study was to identify potential biomarkers about cisplatin resistant cancer cells using comprehensive ceRNA network. Methods GSE6410 (GPL-201) analyzed gene expression changes cispaltin A549 NSCLC cells. GSE43249 (GPL-14613) included noncoding profiling derived from the GEO2R, online analysis tool, differentially expressed...
Abstract Background : Previous studies have shown that RBM10 is a potential tumor suppressor protein can inhibit proliferation and promote apoptosis of NSCLC. bind modify RNA at the post transcriptional level. Method results Transwell cell wound healing assay showed significantly inhibited invasion migration CLIP-seq among all binding RNAs, lncRNA MALAT1 with high m6A methylation in lung cancer had highest peak non-coding RNAs. Immunoprecipitation has verified direct combination MALAT1. The...