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Laura Tasca

ORCID: 0000-0002-7753-3097
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About
Contact & Profiles
A5080858983
Research Areas
  • Cancer-related Molecular Pathways
  • Autophagy in Disease and Therapy
  • Biochemical and Molecular Research
  • PI3K/AKT/mTOR signaling in cancer
  • Chemical Synthesis and Analysis
  • DNA Repair Mechanisms

University of Turin
 2017-2024

Neuroscience Institute
 2017

 Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly
OPENALEX - Publications 
F. Bianchi Chiara Tocco Gianmarco Pallavicini Yifan Liu Fiammetta Vernı̀ and 17 more Chiara Merigliano Silvia Bonaccorsi Nadia El-Assawy Lorenzo Priano Marta Gai Gaia Berto Alessandra Maria Adelaide Chiotto Francesco Sgrò Alessia Caramello Laura Tasca Ugo Ala Francesco Neri Salvatore Oliviero Alessandro Mauro Stephan Geley Maurizio Gatti Ferdinando Di Cunto

Mutations in citron (CIT), leading to loss or inactivation of the kinase protein (CITK), cause primary microcephaly humans and rodents, associated with cytokinesis failure apoptosis neural progenitors. We show that CITK induces DNA damage accumulation chromosomal instability both mammals Drosophila. CITK-deficient cells display "spontaneous" damage, increased sensitivity ionizing radiation, defective recovery from radiation-induced lesions. In cells, double-strand breaks increase...

10.1016/j.celrep.2017.01.054 article EN cc-by-nc-nd Cell Reports 2017-02-01
 A Non-natural Peptide Targeting the A-kinase Anchoring Function of PI3Kγ for Therapeutic cAMP Modulation in Pulmonary Cells
OPENALEX - Publications 
Angela Della Sala Laura Tasca Cosmin Butnarasu Valentina Sala Giulia Prono and 11 more Alessandra Murabito Olga Valentina Garbero Enrico Millo Leonardo Terranova Francesco Blasi Andrea Gramegna Stefano Aliberti Alberto Massarotti Sonja Visentin Emilio Hirsch Alessandra Ghigo

10.1016/j.jbc.2024.107873 article EN cc-by-nc-nd Journal of Biological Chemistry 2024-10-10
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