A5091810752- Mitochondrial Function and Pathology
- Chromosomal and Genetic Variations
- Metabolism and Genetic Disorders
- Genomics and Phylogenetic Studies
- ATP Synthase and ATPases Research
- Genetic diversity and population structure
- RNA modifications and cancer
- Genomics and Rare Diseases
- Cancer, Lipids, and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Identification and Quantification in Food
- Forensic and Genetic Research
- HIV Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Metabolomics and Mass Spectrometry Studies
- Insect and Pesticide Research
- Plant and animal studies
- HIV/AIDS drug development and treatment
- Graphene and Nanomaterials Applications
- Cytomegalovirus and herpesvirus research
- Insect and Arachnid Ecology and Behavior
- Parkinson's Disease Mechanisms and Treatments
- Genetics, Bioinformatics, and Biomedical Research
University of Glasgow
2023-2025
Wellcome Centre for Mitochondrial Research
2018-2024
Newcastle University
2018-2024
University of Otago
2022
Durham University
2022
Northumbria University
2022
King's College London
2022
University of Georgia
2022
University of Sussex
2022
West Virginia University
2022
The functional divergence of duplicate genes (ohnologues) retained from whole genome duplication (WGD) is thought to promote evolutionary diversification. However, species radiation and phenotypic diversification are often temporally separated WGD. Salmonid fish, whose ancestor underwent WGD by autotetraploidization ~95 million years ago, fit such a ‘time-lag’ model post-WGD radiation, which occurred alongside major delay in the rediploidization process. Here we propose model,...
Research Article10 September 2018Open Access Source DataTransparent process OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect Kyle Thompson Wellcome Centre for Mitochondrial Research, Newcastle University, upon Tyne, UK Search more papers by this author Nicole Mai Monika Oláhová Filippo Scialó Institute Cell Molecular Biosciences, University Ageing, Luke E Formosa Department of Biochemistry Biology, Monash Biomedicine Discovery Institute,...
Neurocognitive impairment (NCI) remains common in people living with human immunodeficiency virus (PLWH), despite suppressive antiretroviral therapy (ART), but the reasons remain incompletely understood. Mitochondrial dysfunction is a hallmark of aging and neurodegenerative diseases. We hypothesized that (HIV) or ART may lead to mitochondrial abnormalities brain, thus contributing NCI.
Abstract The functional divergence of duplicate genes (ohnologues) retained from whole genome duplication (WGD) is thought to promote evolutionary diversification. However, species radiation and phenotypic diversification often highly temporally-detached WGD. Salmonid fish, whose ancestor experienced WGD by autotetraploidization ~95 Ma (i.e. ‘Ss4R’), fit such a ‘time-lag’ model post-WGD radiation, which occurred alongside major delay in the rediploidization process. Here we propose called...
Abstract Aberrant mitochondrial function has been associated with an increasingly large number of human disease states. Observations from in vivo models where is altered suggest that adaptations to dysfunction may underpin pathology. We hypothesized the severity these maladaptations could be shaped by plasticity system when manifests. To investigate this, we have used inducible fly complex I (CI) reduce at two stages lifecycle, early development and adult eclosion. Here, show life...
ABSTRACT Mitochondrial disorders exhibit clinical and genetic diversity. Nearly 400 distinct genes, located in both the mitochondrial nuclear genomes, harbor pathogenic variants that can produce a broad spectrum of diseases. This work aims to explore etiology cohort Egyptian pediatric patients who were clinically suspected having disorder. A total 49 from 44 unrelated families studied. Selection criteria included age below 18 years meeting Morava (a score ≥ 3). The disease (MDC) have been...
Recent genomic evidence suggest that kea (Nestor notabilis) have a non-functional RH2 opsin gene potentially leading to impaired vision in the green region of electromagnetic spectrum. In New Zealand, it is standard procedure add dye aerial poison baits used mammalian predator control operations deter native birds from eating toxic bait. A visual deficiency could impact how perceive and interact with green-dyed thus unforeseen consequences for conservation. Here, we sequenced partial seven...