A5017998632- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- Virology and Viral Diseases
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Urticaria and Related Conditions
- Vasculitis and related conditions
- Eosinophilic Disorders and Syndromes
- Animal Disease Management and Epidemiology
- Infection Control and Ventilation
- Viral Infections and Outbreaks Research
Cornell University
2022-2023
New York State College of Agriculture & Life Sciences
2023
National Institute of Allergy and Infectious Diseases
2022
National Institutes of Health
2022
Government of the United States of America
2021
Human cases of SARS-CoV-2 reinfection have been documented throughout the pandemic, but are likely under-reported. In current study, we use Syrian hamster model to assess with homologous WA1 and heterologous B.1.1.7 (Alpha) B.1.351 (Beta) variants over time. Upon primary infection WA1, hamsters rapidly develop a strong long-lasting humoral immune response. After variants, this response protects from clinical disease, virus replication in lower respiratory tract, acute lung pathology....
The continuing emergence of SARS-CoV-2 variants calls for regular assessment to identify differences in viral replication, shedding and associated disease. In this study, we compared African green monkeys infected intranasally with either the UK B.1.1.7 (Alpha) variant or its contemporary D614G progenitor. Both caused mild respiratory disease no significant clinical presentation. Significantly higher levels RNA infectious virus were found upper lower tract samples tissues from animals....
Experimental vaccines for the deadly zoonotic Nipah (NiV), Hendra (HeV), and Ebola (EBOV) viruses have focused on targeting individual viruses, although their geographical bat reservoir host overlaps warrant creation of multivalent vaccines. Here we explored whether replication-incompetent pseudotyped vesicular stomatitis virus (VSV) virions or NiV-based virus-like particles (VLPs) were suitable vaccine platforms by co-incorporating multiple surface glycoproteins from NiV, HeV, EBOV onto...
Abstract The continuing emergence of SARS-CoV-2 variants calls for regular assessment to identify differences in viral replication, shedding and associated disease. In this study, African green monkeys were infected intranasally with either a contemporary D614G or the UK B.1.1.7 variant. Both caused mild respiratory disease no significant clinical presentation. Significantly higher levels RNA infectious virus found upper lower tract samples tissues from animals. Interestingly, animals showed...
Human cases of SARS-CoV-2 reinfection have been documented throughout the pandemic but are likely underreported. In current study, we used Syrian hamster model to assess with homologous (Washington WA1) and heterologous (United Kingdom B.1.1.7 (alpha) South Africa B.1.351 (beta)) variants over time. Upon primary infection WA1, hamsters rapidly developed a strong long-lasting humoral immune response. Following variants, this response protected from clinical disease, virus replication in lower...
Among the forms of pneumorenal syndrome (PRS), one most urgent is characterized by combination diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis (RPGN). In 90% cases, it manifestation an autoimmune disease, such as pauci-immune vasculitis with anti-neutrophil cytoplasmic antibodies (ANCA) or Goodpasture's disease presence directed against basement membrane glomerular capillaries (anti-GBM). These are absent in approximately 10% cases histological confirmation context...