A5068835530- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- MicroRNA in disease regulation
The First People's Hospital of Wenling
2022
Wenzhou Medical University
2018-2022
Glioblastoma (GBM) is the most common and lethal of intracranial tumors, which characterized by extensive proliferation diffused invasion tumor cells. MicroRNA-193a-5p (miR-193a-5p) have been demonstrated previously as a functional suppressor in development progression various cancers. The current study aimed to investigate whether miR-193a-5p influences cell migration through mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway targeting neuro-oncological...
Background. Glioblastoma (GBM) is a highly prevalent brain tumor characterized by high rates of morbidity, recurrence, and mortality. While temozolomide (TMZ) commonly used as first-line treatment for this cancer, the emergence TMZ resistance limits its utility. The long noncoding RNA HOXA-AS2 reportedly drives GBM progression, but whether it can influence therapeutic to has yet be established. Methods. expression was analyzed in TMZ-resistant sensitive tissue samples cell lines qPCR. A...