A5085371439- Computational Drug Discovery Methods
- Pharmacovigilance and Adverse Drug Reactions
- Meta-analysis and systematic reviews
- COVID-19 Clinical Research Studies
- Biosimilars and Bioanalytical Methods
- Pesticide Exposure and Toxicity
- Piperaceae Chemical and Biological Studies
- Topic Modeling
- Diabetes Treatment and Management
- Natural Language Processing Techniques
- Pharmaceutical Economics and Policy
- Mosquito-borne diseases and control
- Essential Oils and Antimicrobial Activity
- Long-Term Effects of COVID-19
- Synthesis and biological activity
- Immunotoxicology and immune responses
- Cholinesterase and Neurodegenerative Diseases
- Ethnobotanical and Medicinal Plants Studies
- Phytochemicals and Medicinal Plants
- Medicinal Plants and Neuroprotection
- Occupational exposure and asthma
- SARS-CoV-2 and COVID-19 Research
- Environmental Toxicology and Ecotoxicology
- Clinical practice guidelines implementation
- Academic integrity and plagiarism
Delhi Pharmaceutical Science and Research University
2021-2025
Pacific Northwest National Laboratory
2025
Battelle
2025
Oak Ridge National Laboratory
2025
Shobhit University
2022-2025
Jain University
2024-2025
Central University of Haryana
2024
Government of India
2024
Ministry of Health and Family Welfare
2024
The University of Western Australia
2023
Abstract Salamanders exhibit an extraordinary ability among vertebrates to regenerate complex body parts. However, scarce genomic resources have limited our understanding of regeneration in adult salamanders. Here, we present the ~20 Gb genome and transcriptome Iberian ribbed newt Pleurodeles waltl , a tractable species suitable for laboratory research. We find that embryonic stem cell-specific miRNAs mir-93b mir-427/430/302, as well Harbinger DNA transposons carrying Myb -like...
Background & objective: Molecular dynamics simulations (MDS) using GROMACS are among the commonly used computational experiments in area of molecular biology and drug discovery. This article presents a project called HeroMDAnalysis, an automagical tool to analyze GROMACS-based MDS trajectories generate plots as high-quality images for various parameters. Materials methods: The was built bash shell programming, graphical user interface Zenity engine. Results conclusion: offers simple,...
Background DNA barcoding as a tool for species identification has been successful in animals and other organisms, including certain groups of plants. The exploration this new identification, particularly tree species, is very scanty from biodiversity-rich countries like India. rbcL matK are standard barcode loci while ITS, trnH-psbA considered supplementary Methodology Principal Findings Plant loci, namely, rbcL, matK, trnH-psbA, the recently proposed ITS2, were tested their efficacy using...
To identify novel targets for neuropathic pain, 3097 mouse knockout lines were tested in acute and persistent pain behavior assays. One of the from this screen, which contained a null allele adapter protein-2 associated kinase 1 (AAK1) gene, had normal response assays (hot plate, phase I formalin), but markedly reduced to II formalin. AAK1 mice also failed develop tactile allodynia following Chung procedure spinal nerve ligation (SNL). Based on these findings, potent, small-molecule...
ABSTRACT Deltamethrin (DLM) is a well‐known pyrethroid insecticide used extensively in pest control. Exposure to DLM has been demonstrated cause apoptosis various cells. However, the immunotoxic effects of on mammalian system and its mechanism still an open question be explored. To explore these effects, this study designed first observe interactions immune cell receptors system. The docking score revealed that strong binding affinity toward CD45 CD28 receptors. In vitro induces murine...
Abstract Antiviral drugs are not known for drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. The current study aims is to find out the association of antiviral their possible mechanism DRESS. Data mining algorithms such as proportional reporting ratio that is, PRR (≥2) associated χ 2 value (>4), odds ROR 95% confidence interval case count (≥3) were calculated identify a signal. Further, molecular docking studies conducted check interaction selected targets. potential...
Early signal detection from post-marketing studies play a vital role in the safety of patients. Recent case reports have indicated association clindamycin with renal failure acute. However, acute is not known to be associated clindamycin. The aim study was identification potential clindamycin-associated acute.The OpenVigil 2.1-MedDRA-v24 used query FAERS database. Reporting Odds Ratio (ROR) 95% confidence interval, assess between and acute.A total 22326 cases were found 2.1- MedDRA-v24....
<title>Abstract</title> Ethnic diversity in breast cancer often results overlapping genetic profiles, complicating prognosis despite evolving classification methods. The present study examines transcriptomic variations between Caucasian and Indian populations through a cross-population analysis to assess whether genes differentially expressed among women show similar patterns women. Utilizing datasets from middle-aged with (SRA Project: SRP375823), we performed RNA-seq using the GATK Tuxedo...
Candida albicans infections and their resistance to clinically approved azole drugs are major concerns for human. The antifungal inhibit the ergosterol synthesis by targeting lanosterol 14α-demethylase of cytochrome P450 family. lack high-resolution structural information fungal pathogens has been a barrier design modified drugs. Thus, preliminary theoretical molecular dynamic study is carried out develop validate simple homologous model using crystallographic structure Mycobacterium...
Clobazam is a well-known benzodiazepine used as an anti-anxiety drug well anti-epileptic, particularly for patients who are not responding to first-line treatments. Recent case reports have indicated the association of clobazam with reaction eosinophilia systemic symptoms syndrome (DRESS Syndrome). However, DRESS known be associated clobazam. Thus, main objective current study was identify potential signal clobazam-associated Syndrome.US FDA Adverse event reporting system (US FAERS),...
Various adverse drug reactions (ADRs) are associated with proton pump inhibitors (PPIs). However, the effects of PPIs on renal system unclear so far. Thus, main objective current study was to identify possible signals in system.Data mining algorithms such as proportional reporting ratio i.e. PRR (≥2) chi-squared value (>4), odds ROR 95% confidence interval and case count (≥3) were calculated a signal.The have indicated positive signal suspected chronic kidney disease, acute injury, failure,...
The citrus canker pathogen Xanthomonas axonopodis has caused severe damage to crops worldwide, resulting in significant economic losses for the industry. To address this, a green synthesis method was used develop silver nanoparticles with leaf extract of Phyllanthus niruri (GS-AgNP-LEPN). This replaces need toxic reagents, as LEPN acts reducing and capping agent. further enhance their effectiveness, GS-AgNP-LEPN were encapsulated extracellular vesicles (EVs), nanovesicles diameter...