A5016096598- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Invertebrate Immune Response Mechanisms
- RNA modifications and cancer
- Aquaculture disease management and microbiota
- Estrogen and related hormone effects
- Cancer, Stress, Anesthesia, and Immune Response
- Genetic Neurodegenerative Diseases
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Synthesis and biological activity
- Bacteriophages and microbial interactions
- Neurobiology and Insect Physiology Research
- Menopause: Health Impacts and Treatments
- Bone Metabolism and Diseases
- RNA regulation and disease
- Cytokine Signaling Pathways and Interactions
- Alzheimer's disease research and treatments
- Mosquito-borne diseases and control
- Synthesis and Biological Evaluation
- Endometriosis Research and Treatment
- RNA and protein synthesis mechanisms
- Cancer therapeutics and mechanisms
- Physiological and biochemical adaptations
- Cellular transport and secretion
Universidad del Norte
2017-2024
National Cancer Institute
2015-2018
Vall d'Hebron Institut de Recerca
2018
Center for Cancer Research
2016-2017
University of Sheffield
2010-2013
Karolinska Institutet
2006
Centro de Investigación de la Caña de Azúcar de Colombia
2001-2006
Institute of Reproductive Medicine
2006
Hospital Universitario Dr José Eleuterio Gonzalez
2004
Sahlgrenska University Hospital
1999-2002
Ovariectomy in young, growing rodents results decreased trabecular bone mineral density (BMD) and increased radial growth of the cortical bone. Both these effects are reversed by treatment with estrogen. The aim present study was to determine physiological role estrogen receptor-β (ERβ) on structure content (BMC). BMC adult (11 weeks old), but not prepubertal (4 female ERβ–/– mice compared wild-type (WT) mice. This increase females due BMD, an cross-sectional area associated a growth. Male...
Abstract This study was conducted to examine the effect of increasing seawater temperature on White Spot Syndrome Virus (WSSV) infection in juvenile Pacific shrimp ( Litopenaeus vannamei ). Infection by WSSV achieved using two methods, intramuscular injection and per os (oral) administration. Forty injected 20 infected animals were kept heated tanks at 32.3 ± 0.8 C, same number maintained ambient (25.8 0.7 C). Despite route exposure, there no survivors among temperature; whereas, survival...
Estrogen exerts a variety of important physiological effects, which have been suggested to be mediated via the two known estrogen receptors (ERs), alpha and beta. Three-month-old ovariectomized mice, lacking one or both receptors, were given subcutaneously (2.3 micro g/mouse per day) effects on different estrogen-responsive parameters, including skeletal studied. We found that increased cortical bone dimensions in wild-type (WT) double ER knockout (DERKO) mice. DNA microarray analysis was...
DAO Diseases of Aquatic Organisms Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsSpecials 54:73-78 (2003) - doi:10.3354/dao054073 Does hyperthermia increase apoptosis in white spot syndrome virus (WSSV)-infected Litopenaeus vannamei? Clarissa B. Granja*, Luis Fernando Aranguren, Oscar M. Vidal, Lacides Aragón, Marcela Salazar Corporación Centro de Investigación la Acuicultura Colombia (CENIACUA), Carrera...
Abstract HIV infection has a tremendous impact on the immune system’s proper functioning. The mucosa-associated lymphoid tissue (MALT) is significantly disarrayed during infection. Compositional changes in gut microbiota might contribute to mucosal barrier disruption, and consequently microbial translocation. We performed an observational, cross-sectional study aimed at evaluating fecal of HIV-infected individuals from Colombia. analyzed 37 via 16S rRNA gene sequencing; 25 patients 12...
Eight quinoline-based hydroxyimidazolium hybrids 7a-h were prepared and evaluated in vitro against a panel of clinically important fungal bacterial pathogens, including mycobacteria. Hybrid compounds 7c-d showed remarkable antifungal activity Cryptococcus neoformans with minimum inhibitory concentration (MIC) value 15.6 µg/mL. Against other opportunistic fungi such as Candida spp. Aspergillus spp., these MIC values 62.5 Regarding their antibacterial activity, all the synthetic demonstrated...
The GH-activated signal transducer and activator of transcription 5b (STAT5b) is an essential regulator somatic growth. transcriptional response to STAT5b in liver poorly understood. We have combined microarray-based expression profiling phylogenetic analysis gene regulatory regions study the interplay between GH regulation hepatic expression. acute vivo after a single pulse was studied hypophysectomized rats presence either constitutively active or dominant-negative delivered by adenoviral...
DAO Diseases of Aquatic Organisms Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsSpecials 68:175-180 (2006) - doi:10.3354/dao068175 Hyperthermia reduces viral load white spot syndrome virus in Penaeus vannamei Clarissa B. Granja*, Oscar M. Vidal, Gustavo Parra, Marcela Salazar Corporación Centro de Investigación la Acuicultura Colombia (CENIACUA), Carrera 8ª # 96-60, Bogotá, *Email: cbgranja@yahoo.com...
Alzheimer's disease (AD), a neurodegenerative disorder characterized by progressive cognitive decline, is the most common form of dementia. Currently, there no single test that can diagnose AD, especially in understudied populations and developing countries. Instead, diagnosis based on combination medical history, physical examination, testing, brain imaging. Exosomes are extracellular nanovesicles, primarily composed RNA, participate physiological processes related to AD pathogenesis such...
Conserved from humans to Drosophila, the Janus kinase/signal transducer and activators of transcription (JAK/STAT) signaling cascade is essential for multiple developmental homeostatic processes, with regulatory molecules controlling pathway activity also highly conserved. We characterize Drosophila JAK/STAT regulator SOCS36E show that it functions via two independent mechanisms. First, we Elongin B/C Cullin-5 act SOCS-box reduce specifically in response ligand stimulation--a process...
Appropriate regulation of signal transduction pathways is essential for normal development and often disrupted in disease. Therefore, many regulatory mechanisms feedback loops have evolved to ensure appropriate signalling. One mechanism previously suggested modulate a range involves the internalisation destruction transmembrane receptors by endocytic trafficking machinery. Strikingly, recent report has that Drosophila JAK–STAT pathway receptor Domeless (Dome) does not act downregulate...
A new series of sulfonamides, 8a-b, 10, 12, and 14a-b, were synthesized by N-sulfonation reaction with sulfonyl chlorides 6a-b. Five chalcone-sulfonamide hybrids (16-20)a-f prepared via Claisen-Schmidt condensation the newly obtained sulfonamides aromatic aldehydes 15a-f in basic medium. Chalcones substituted chlorine at position 4 each used as precursors for generation their five-membered heterocyclic pyrazoline (22-23)a-d, (24-25)a-b carbothioamide 27a-f derivatives. The compounds...
A whole-exome capture and next-generation sequencing was applied to an 11 y/o patient with a clinical history of congenital hypotonia, generalized motor cognitive neurodevelopmental delay, severe deficit, without any identifiable Syndromic pattern, her parents, we disclosed de novo heterozygous pathogenic mutation, c.697_699del p.Phe233del (rs786204835)(ACMG classification PS2, PM1, PM2, PP5), harbored in the PURA gene (MIM*600473) (5q31.3), associated Autosomal Dominant Mental Retardation...
In this study, a series of novel quinolinone-based thiosemicarbazones were designed in silico and their activities tested vitro against Mycobacterium tuberculosis (M. tuberculosis). Quantitative structure-activity relationship (QSAR) studies performed using quinolinone thiosemicarbazide as pharmacophoric nuclei; the best model showed statistical parameters R2 = 0.83; F 47.96; s 0.31, was validated by several different methods. The van der Waals volume, electron density, electronegativity...
Chikungunya virus (CHIKV), a mosquito-borne alphavirus of the Togaviridae family, is part group emergent diseases, including arbovirus, constituting an increasing public health problem in tropical areas worldwide. CHIKV causes severe and debilitating disease with high morbidity. The first Colombian autochthonous case was reported Caribbean region September 2014. Within next two to three months, outbreak reached its peak. Although pattern clinical symptomatology has been documented different...
Alzheimer's disease (AD) is progressive brain disorder that affects ~ 50 million people worldwide and has no current effective treatment. AD age of onset (ADAOO) shown to be critical for the identification genes modify appearance signs symptoms in a specific population. We clinically characterized whole-exome genotyped 71 individuals with from Paisa genetic isolate, segregating (PSEN1) E280A dominant fully penetrant mutation, analyzed potential recessive effects 50,000 common functional...
(1) Background: Information regarding gene expression profiles and the prognosis of community-acquired pneumonia (CAP) is scarce. We aimed to examine differences in peripheral blood at hospital admission between patients with CAP who died during hospitalization those survived. (2) Methods: This a multicenter study nonimmunosuppressed adult required for CAP. Whole samples were obtained within 24 h genome-expression-profile analysis. Gene profiling identified both differentially expressed...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and memory loss. While the precise causes of AD remain unclear, emerging evidence suggests that messenger RNA (mRNA) dysregulation contributes to pathology risk. This study examined exosomal mRNA expression profiles 15 individuals diagnosed with healthy controls from Barranquilla, Colombia. Utilizing advanced bioinformatics machine learning (ML) techniques, we identified differentially...
Abstract Attention deficit/hyperactivity disorder (ADHD) is the most common childhood neurodevelopmental disorder. Single nucleotide polymorphisms (SNPs) in Adhesion G Protein-Coupled Receptor L3 ( ADGRL3 ) gene are associated with increased susceptibility to developing ADHD worldwide. However, effect of non-synonymous SNPs (nsSNPs) on protein function vastly unknown. Using several bioinformatics tools evaluate impact mutations, we found that nsSNPs rs35106420, rs61747658, and rs734644,...
Presented here are five members of a family that was ascertained from an isolated, consanguineous, indigenous Amerindian community in Colombia affected with calpain 3-related, limb-girdle muscular dystrophy type R1. These patients homozygous for unique and novel deletion four bases (TGCC) exon 3 the gene (CAPN3) (NM_000070.2; NP_000061.1) (g.409_412del). The mutation site occurs at CysPc protein domain, triggering modified truncated structure affecting motifs within calpain-like thiol...