A5051261889- Fibroblast Growth Factor Research
- Receptor Mechanisms and Signaling
- Epigenetics and DNA Methylation
- Computational Drug Discovery Methods
- Connective tissue disorders research
- Proteoglycans and glycosaminoglycans research
- Axon Guidance and Neuronal Signaling
- Wnt/β-catenin signaling in development and cancer
- Hippo pathway signaling and YAP/TAZ
- Medicinal Plant Pharmacodynamics Research
- PI3K/AKT/mTOR signaling in cancer
- Protein Kinase Regulation and GTPase Signaling
- Advanced Biosensing Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Protein Tyrosine Phosphatases
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
Johns Hopkins University
2019-2024
Materials Science & Engineering
2023-2024
Czech Academy of Sciences, Institute of Animal Physiology and Genetics
2023
Institute of Nanotechnology
2023
Masaryk University
2023
St. Anne's University Hospital Brno
2023
University Hospital Brno
2023
Goethe Institut
2023
Goethe University Frankfurt
2023
The differential signaling of multiple FGF ligands through a single fibroblast growth factor (FGF) receptor (FGFR) plays an important role in embryonic development. Here, we use quantitative biophysical tools to uncover the mechanism behind differences FGFR1c response FGF4, FGF8, and FGF9, process which is relevant for limb bud outgrowth. We find that FGF8 preferentially induces FRS2 phosphorylation extracellular matrix loss, while FGF4 FGF9 induce cell arrest. Thus, demonstrate biased...
The Eph receptor tyrosine kinases and their ephrin ligands regulate many physiological pathological processes. EphA4 plays important roles in nervous system development adult homeostasis, while aberrant signaling has been implicated neurodegeneration. may also affect cancer malignancy, but the regulation effects of are poorly understood. A correlation between decreased patient survival high mRNA expression melanoma tumors that highly express ephrinA suggests enhanced contribute to...
The differential signaling of multiple FGF ligands through a single fibroblast growth factor (FGF) receptor (FGFR) plays an important role in embryonic development. Here, we use quantitative biophysical tools to uncover the mechanism behind differences FGFR1c response FGF4, FGF8, and FGF9, process which is relevant for limb bud outgrowth. We find that FGF8 preferentially induces FRS2 phosphorylation extracellular matrix loss, while FGF4 FGF9 induce cell arrest. Thus, demonstrate biased...
Long-term potentiation (LTP) in the CA1 region of hippocampus is a stable enhancement synaptic transmission that occurs following brief periods high-frequency activity. The biophysical and biochemical events responsible for LTP have been studied extensively as possible cellular mechanism underlying changes efficacy involved certain types learning memory vertebrate brain. Whereas it known coincident patterns activity can induce by virtue their ability to elicit activation N-methyl-d-aspartate...
FGFR1 signals differently in response to the fgf ligands FGF4, FGF8 and FGF9, but mechanism behind differential ligand recognition is poorly understood. Here, we use biophysical tools quantify multiple aspects of signaling three FGFs: potency, efficacy, bias, ligand-induced oligomerization downregulation, conformation active dimers. We find that exhibit distinctly different potencies efficacies for inducing responses cells. further a biased ligand, as compared FGF4 FGF9. This bias evident...
The mechanism of differential signaling multiple FGF ligands through a single receptor is poorly understood. Here, we use biophysical tools to quantify aspects FGFR1 in response FGF4, FGF8 and FGF9: potency, efficacy, bias, ligand-induced oligomerization downregulation, conformation the active dimers. We find that three exhibit distinctly different potencies efficacies for inducing responses cells. further discover qualitative differences actions FGFs FGFR1, as preferentially activates some...
Abstract The mechanism of differential signaling multiple FGF ligands through a single receptor is poorly understood. Here, we use biophysical tools to quantify aspects FGFR1 in response FGF4, FGF8 and FGF9: potency, efficacy, bias, ligand-induced oligomerization downregulation, conformation the active dimers. We find that three exhibit distinctly different potencies efficacies for inducing responses cells. further discover qualitative differences actions FGFs FGFR1, as preferentially...
FGFR1 signals differently in response to the fgf ligands FGF4, FGF8 and FGF9, but mechanism behind differential ligand recognition is poorly understood. Here, we use biophysical tools quantify multiple aspects of signaling three FGFs: potency, efficacy, bias, ligand-induced oligomerization downregulation, conformation active dimers. We find that exhibit distinctly different potencies efficacies for inducing responses cells. further a biased ligand, as compared FGF4 FGF9. This bias evident...