A5101841864- Esophageal and GI Pathology
- Nutrition and Health in Aging
- Multiple and Secondary Primary Cancers
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Childhood Cancer Survivors' Quality of Life
- Lipid Membrane Structure and Behavior
- Palliative Care and End-of-Life Issues
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- CNS Lymphoma Diagnosis and Treatment
- GDF15 and Related Biomarkers
- Proteoglycans and glycosaminoglycans research
- Metastasis and carcinoma case studies
- Clinical Nutrition and Gastroenterology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Adenosine and Purinergic Signaling
- Cancer-related Molecular Pathways
- Thyroid Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Cellular transport and secretion
- Systemic Sclerosis and Related Diseases
- Glycosylation and Glycoproteins Research
Keimyung University
2025
Cedars-Sinai Medical Center
2019-2022
Korea Advanced Institute of Science and Technology
2015
Abstract The mechanical elasticity of lipid nanoparticles (LNPs) is crucial to their pharmaceutical performance. This study investigates how the interactions between LNPs, target cells, and macrophages affect internalization LNPs into cells at tumor sites. According our bio‐mechanical study, drug‐resistant breast cancer are stiffer than sensitive ones, while invasive softer; similarly, protumoral M2 softer M1 macrophages. Softer show increased cellular uptake in macrophages, with enhanced...
Advanced pancreatic ductal adenocarcinoma (PDAC) is characterized by progressive weight loss and nutritional deterioration. This wasting has been linked to poor survival outcomes, alterations in host defenses, decreased functional ability, diminished health-related quality of life (HRQOL) cancer patients. There are currently no standardized approaches the management cachexia. study explores feasibility efficacy enteral tube feeding a peptide-based formula improve stability patient-reported...
Impact of palliative therapies in metastatic esophageal cancer patients not receiving chemotherapy
4634 Background: Interleukin-1-alpha (IL-1α) promotes tumor inflammation by shaping the microenvironment, including infiltrating myeloid cell recruitment, angiogenesis, and skewing suppression of anti-tumor immunity. IL-1a inhibition in cancer subjects increased lean body mass decreased fatigue, pain, appetite loss. We report results a single site phase 1 trial for an IL-1α antagonist (bermekimab) combination with nanoliposomal irinotecan (Nal-Iri) 5-fluorouracil (5FU)/folinic acid (FA)...
726 Background: Unintentional weight loss affecting > 85% of pancreatic cancer (PC) patients contributes to low therapeutic tolerance, reduced quality life, and overall mortality. Optimal treatment approaches have not been developed. We hypothesize that peptide-based enteral nutritional support in cachectic advanced PC patients, receiving palliative chemotherapy, results improved weight, lean body mass (LBM), hand-grip strength. Methods: Pancreatic adenocarcinoma with cachexia (> 5%...
Hyaluronan (HA) accumulation is associated with tumorigenesis and aggressive tumor behavior.We investigated the biomarker potential of HA in non-small cell lung cancer (NSCLC).HA levels were scored using affinity histochemistry 137 NSCLC samples stratified by score ≤10, 11-20, 21-30, >30 HA-high defined as ≥25% expression extracellular matrix (ECM) surface area. Overall survival (OS) time to progression from initiation taxane therapy (TTP) compared log-rank tests based on score.Of 122...
N-ethylmaleimide-sensitive factor (NSF) and alpha soluble NSF attachment protein (α-SNAP) disassemble the SNAP receptor (SNARE) complex for recycling of SNARE proteins. Using single-molecule fluorescence force spectroscopy, we found that appears to use a "spring-loaded" mechanism.
Abstract Background: Patients with pancreatic cancer often develop progressive weight loss and sarcopenia, described as cachexia syndrome. Despite evidence showing that is associated a poor prognosis, reduced tolerance to therapy, diminished quality of life, no predictive biomarkers have been identified date. Certain mutant KRAS isoforms are significant alterations tumor metabolism correlated changes in survival. However, the clinical implications resulting from specific mutations yet be...
316 Background: We investigated predictors for chemotherapy (CTX) and prognostic variables in a large metastatic esophageal cancer (mEC) patient data set. Methods: interrogated the National Cancer Database between 2004-2015 included patients (pts) with M1 disease who had known CTX status (received or did not receive CTX). Univariable multivariable analyses were performed, logistic regression model was used to estimate effect of adjustment potential confounders. Results: 12,370 mEC available...
315 Background: Palliative care has been associated with improved overall survival (OS), but limited data exist in metastatic esophageal cancer (mEC). We investigated the impact of palliative patients mEC who declined chemotherapy (CTX). Methods: The National Cancer Database was used to identify between 2004-2015. Patients M1 disease CTX and had known status (surgery, radiotherapy [RT], pain management, or any combination of) were included. Cases unknown CTX, RT, nonprimary surgery excluded....
e16564 Background: In rGC ( > cT2), we investigated the impact of various neoadjuvant and/or adjuvant treatment modalities on pathologic complete response (pCR), surgical margins, and overall survival (OS). Methods: The National Cancer Database (NCDB) was interrogated to identify patients (pts) between 2004-2015. Gastric adenocarcinoma cases that were cT2-T4b, any N, M0 underwent definitive surgery included. We analyzed association 9 groups: chemoradiation only (nCRT), chemo (nCT), (aCT),...