A5081040315- Statistical Methods in Clinical Trials
- Colorectal Cancer Treatments and Studies
- Cancer survivorship and care
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Diet and metabolism studies
- Economic and Financial Impacts of Cancer
- Meta-analysis and systematic reviews
- Biosimilars and Bioanalytical Methods
- Hepatocellular Carcinoma Treatment and Prognosis
- Physical Activity and Health
- Childhood Cancer Survivors' Quality of Life
- Computational Drug Discovery Methods
- Nutrition and Health in Aging
- Multiple and Secondary Primary Cancers
- Advanced Causal Inference Techniques
- Pharmacogenetics and Drug Metabolism
- Lipoproteins and Cardiovascular Health
- Colorectal Cancer Screening and Detection
- Cancer, Hypoxia, and Metabolism
Cedars-Sinai Medical Center
2017-2025
Sinai Health System
2023
Johns Hopkins University
2014-2022
Brigham and Women's Hospital
2020-2022
Harvard University
2020
Samueli Institute
2020
University of Ottawa
2012-2019
Ottawa Hospital
2012-2019
University of Toronto
2019
Ottawa University
2019
An objective evaluation of patient performance status (PS) is difficult because patients spend the majority their time outside clinic, self-report to providers, and undergo dynamic changes throughout treatment experience. Real-time, activity data may allow for a more accurate assessment PS physical function, while reducing subjectivity bias associated with current assessments. Consenting advanced cancer wore wearble monitor three consecutive visits in prospective, single-cohort clinical...
The Eastern Cooperative Oncology Group Performance Status (ECOG-PS) scale is commonly used by physicians and nurses in oncology, as it correlates with cancer morbidity, mortality, complications from chemotherapy can help direct clinical decisions prognostication. This retrospective cohort study aimed to identify whether ECOG-PS scores rated oncologist versus differ their ability predict outcomes.Over 19 months, 32 oncologists 41 a single academic comprehensive center independently scored...
<h3>Importance</h3> ClinicalTrials.gov is a valuable resource that can be used to trace the state and nature of trials. Since its launch in 2000, more than 345 000 trials have been registered. Little known about characteristics trends clinical over time how they differ by sponsor type. <h3>Objective</h3> To assess registered <h3>Design, Setting, Participants</h3> This cross-sectional study included (interventional studies) from January 1, through December 31, 2019. The were grouped lead...
Background: Recently, the ketogenic diet has been proposed as an adjunct treatment for a range of medical conditions including weight loss, diabetes, cancer, and neurodegenerative diseases. Because malignant CNS tumors are highly dependent on glucose, use therapy is currently being explored. This case series summarizes our experience implementing patients with malignancies. Methods: Patients diagnosed malignancies following were identified between 2015 2017. Malignancies included confirmed...
Digital health technology has the potential to revolutionise geriatric care. The digital divide decreased among older adults,1The Lancet Healthy LongevityTackling divide.Lancet Longev. 2021; 2: e601Summary Full Text PDF Google Scholar and over a third of adults aged 50 years in USA already use for or independence.2Kakulla B Older embrace tech entertainment day-to-day living.https://www.aarp.org/research/topics/technology/info-2022/2022-technology-trends-older-americans.htmlDate: December,...
Pancreatic and gastrointestinal cancers are associated with debility, frailty, chemotherapy regiments significant toxicity. Practical exercise guidelines to combat these ailments optimize functional status lacking. We present a model for based on the Dietz framework rehabilitation in cancer. The describes four phases of including preventative (prehabilitation), restorative, supportive, palliative. practical at each phase. Prehabilitation seeks performance typically prior surgical resection...
Cognitive training and physical activity independently provide benefits in cognitive functioning. However, less is known about the of combining sustained training. The Walk Play pilot randomized controlled trial compares preliminary efficacy daily walking gamified inhibitory control on outcomes among individuals endorsing challenges. After a seven-day run-in period, participants were randomly assigned to one two conditions for three weeks: (1) 30-min walks (Walk) or (2) alternating between...
Abstract Background Previous research demonstrates longer survival for patients with lung-only metastatic pancreatic adenocarcinoma (mPDAC) compared to liver-only mPDAC. The objective of this study is understand the differences, impact chemotherapy, and associated genomic features mPDAC that isolated either liver or lung. Patients methods Longitudinal clinical outcomes molecular sequencing data were retrospectively analyzed across 831 PDAC all stages whose tumors first metastasized Survival...
Abstract Background The PRO-CTCAE Measurement System was designed to enhance the quality of standard toxicity evaluation in clinical trials. We developed a sub-study within NRG BR004, phase III trial patients with newly documented HER2-positive metastatic breast cancer (MBC), examine added value and feasibility frequent data collection. Methods Patients were asked complete 23 items assessing 12 symptoms. Electronic PRO (ePRO) reporting preferred; however, paper administration allowed. on...
BACKGROUND Fatigue is prevalent and distressing among cancer survivors, but its subjective nature makes it difficult to identify. Fatigability, defined as task‐specific fatigue, endurance performance may be useful supplemental measures of functional status in survivors. METHODS performance, history were assessed every 2 years Baltimore Longitudinal Study Aging participants between 2007 2015. Fatigability was according the Borg rating perceived exertion scale after a 5‐minute, slow treadmill...
Abstract Background The National Cancer Institute Moonshot research initiative calls for improvements in the analysis and reporting of treatment toxicity to advise key stakeholders on tolerability inform regulatory clinical decision making. This study illustrates alternative approaches evaluation using Surgical Adjuvant Breast Bowel Project R-04 trial as an example. Methods was a neoadjuvant chemoradiation stage II–III rectal cancer patients. A 2 x factorial design used evaluate whether...
Background The National Institutes of Health is one the largest biomedical research agencies in world. Clinical trials are an important component efforts. Given recent updates trial reporting requirements, more information regarding current state Health–funded clinical warranted. objective this analysis was to describe characteristics and trends funded by over time Centers Health. Methods Interventional studies registered ClinicalTrials.gov between 2005 2015 were included analysis. Trials...
Advanced pancreatic ductal adenocarcinoma (PDAC) is characterized by progressive weight loss and nutritional deterioration. This wasting has been linked to poor survival outcomes, alterations in host defenses, decreased functional ability, diminished health-related quality of life (HRQOL) cancer patients. There are currently no standardized approaches the management cachexia. study explores feasibility efficacy enteral tube feeding a peptide-based formula improve stability patient-reported...
Abstract Background The clinical trial landscape has evolved over the last two decades, shaped by advances in therapeutics and drug development innovation design methods. tracking of such changes became possible with registration, providing public a window into massive research enterprise. ClinicalTrials.gov website was launched 2000 NIH National Library Medicine is largest registry worldwide. purpose this analysis to describe composition methodologic features trials as registered on...
Background Using objectively collected physical activity (PA) data from the Baltimore Longitudinal Study of Aging, authors tested whether patterns daily and sedentary time differed by cancer survivorship in older adults. Methods In total, 659 participants (mean age ± standard deviation, 71 10 years; 51% women) who had self‐reported information on history were instructed to wear an accelerometer for 7 consecutive days. Accelerometer summarized into: 1) PA volume 2) fragmentation (interrupted...