A5045532681- Skin Protection and Aging
- Photodynamic Therapy Research Studies
- Infection Control and Ventilation
- Indoor Air Quality and Microbial Exposure
- Nonmelanoma Skin Cancer Studies
- Nanoplatforms for cancer theranostics
- Psoriasis: Treatment and Pathogenesis
- Dermatologic Treatments and Research
- Ocular and Laser Science Research
- Contact Dermatitis and Allergies
- Optical Coherence Tomography Applications
- Laser Applications in Dentistry and Medicine
- Photoacoustic and Ultrasonic Imaging
- Cutaneous Melanoma Detection and Management
- Urban Heat Island Mitigation
- Ocular Surface and Contact Lens
- Glioma Diagnosis and Treatment
- Cholinesterase and Neurodegenerative Diseases
- Advanced Radiotherapy Techniques
- Porphyrin Metabolism and Disorders
- Climate Change and Health Impacts
- Effects of Radiation Exposure
- COVID-19 and healthcare impacts
- Acne and Rosacea Treatments and Effects
- Energy and Environmental Systems
Ninewells Hospital
2016-2025
NHS Tayside
2016-2024
University of Dundee
2007-2024
Oxfam
2021
John Wiley & Sons (United States)
2021
Hudson Institute
2021
John Wiley & Sons (United Kingdom)
2021
Division of Undergraduate Education
2020
Scientific Services
2017
ABSTRACT An increase in the use of light‐based technology and medical devices has created a demand for informative accessible data showing depth that light penetrates into skin how this varies with wavelength. These would be particularly beneficial many areas research support development disease‐targeted therapies specific diseases, based on increased understanding wavelength‐dependency cutaneous penetration effects. We have used Monte Carlo radiative transport (MCRT) to simulate propagation...
Many infectious diseases, including COVID-19, are transmitted by airborne pathogens. There is a need for effective environmental control measures which, ideally, not reliant on human behaviour. One potential solution Krypton Chloride (KrCl) excimer lamps (often referred to as Far-UVC), which can efficiently inactivate pathogens, such coronaviruses and influenza, in air. Research demonstrates that when KrCl filtered remove longer-wavelength ultraviolet emissions they do induce acute reactions...
Abstract Far‐UVC devices are being commercially sold as “safe for humans” the inactivation of SARS‐CoV‐2, without supporting human safety data. We felt there was a need rapid proof‐of‐concept self‐exposure, to inform future controlled research and promote informed discussion. A Fitzpatrick Skin Type II individual exposed their inner forearms large radiant exposures from filtered Krypton‐Chloride (KrCl) far‐UVC system (SafeZoneUVC, Ushio Inc., Tokyo, Japan) with peak emission at 222 nm. No...
Abstract Far‐UVC, from filtered Krypton‐Chloride lamps, is promising for reducing airborne transmission of disease. While significant research has been undertaken to investigate skin safety these less work on eye safety. There limited data human or discomfort the deployment this germicidal technology. In pilot study, immediate and delayed were assessed in a simulated office environment with located ceiling directed downwards into occupied room. Discomfort was immediately postexposure several...
COVID-19 was devastating for many dermatology services. But four years on, what is the lasting impact on ultraviolet phototherapy? A quarter less patients being treated with UV phototherapy and an increase in patient waiting times.
Abstract Linked Comment: P. Wolf. Br J Dermatol 2022; 187:285–286.
SignificanceGlioblastoma (GBM) is a rare but deadly form of brain tumor with low median survival rate 14.6 months, due to its resistance treatment. An independent simulation the INtraoperative photoDYnamic therapy for GliOblastoma (INDYGO) trial, clinical trial aiming treat GBM resection cavity photodynamic (PDT) via laser coupled balloon device, demonstrated.AimTo develop framework providing increased understanding PDT treatment, parameters, and their impact on outcome.ApproachWe use Monte...
Abstract Nonmelanoma and melanoma skin cancers are attributable to DNA damage caused by ultraviolet ( UV ) radiation exposure. One photoproduct, the cyclobutane pyrimidine dimer CPD ), is believed lead mutations radiation. Using radiative transfer simulations, we compare number of s directly induced irradiation from artificial natural sources (a standard sunbed midday summer Mediterranean sun) for types I II on Fitzpatrick scale. We use Monte Carlo MCRT modeling track progression photons...
Background: Unlike medical lasers, intense pulsed light (IPL) devices are largely unregulated and unclassified as to degree of safety hazard. With the exception most USA, United Kingdom parts Europe, Far East Australia, sale IPLs is generally unrestricted, with majority being sold into beauty therapy spa markets. Standards only imposed on manufacturers for technical performance data operating tolerances determined by CE‐compliance under electrical standards or EU Medical Device Directive....
Background Exposure to ultraviolet (UV) radiation from sunlight is recognized as the principal cause of skin cancer. Moreover, sunbeds have been classified carcinogenic by International Agency for Research on Cancer. Despite this, there a shortage objective data UV exposure levels in England. Objectives We set out measure emission at sites around England, and compare these with both current standards natural sunlight. Methods Between October 2010 February 2011, spectra were measured site...
Daylight PDT (dPDT) is an effective and nearly painless treatment for field‐change actinic keratosis. Measuring the protoporphyrin‐IX (PpIX)‐weighted exposure dose can give indication of when conditions are most viable dPDT. It would be advantageous practitioners if more detailed information appropriate were available. Where sophisticated measurement equipment unavailable, simpler cost‐effective methods desirable. To devise a model whereby illuminance data converted into PpIX‐weighted dose,...
Compact fluorescent lamps (CFLs) are due to replace common incandescent over the next few years. There has been no investigation of possible effect this on patients with photosensitive disorders.To determine exposure individuals light from CFLs.The spectral emission a sample CFLs was measured using calibrated spectroradiometer. The erythemal response determined in one normal individual and four by direct skin CFL. susceptibility wider group predicted based dose known elicit reaction during...
Intense pulsed light (IPL) systems have evolved and crossed over from the clinic to home. Studies shown home-use IPLs be clinically effective but there has been no published data on ocular safety. It was our aim measure spectral temporal optical radiation output a IPL assess hazard.The iPulse Personal is new hair reduction system. We measured its using calibrated diode array spectrometer that traceable national standards. Pulse duration determined by measurement with fast photodiode. The...
Chronic sun-induced dysplastic skin changes (actinic keratoses) are extremely common in fair-skinned people Scotland. These a major cause of morbidity and may develop into cancer. Actinic keratoses often extensive pose therapeutic challenge as field-directed treatment is required for chronic disease management. One such approach hospital-based photodynamic therapy, which well-established Scotland actinic keratoses, using photosensitiser pro-drug red LED light irradiation. However, therapy...