A5076574442- Neurobiology and Insect Physiology Research
- Physiological and biochemical adaptations
- Insect and Arachnid Ecology and Behavior
- Invertebrate Immune Response Mechanisms
- Phytochemical Studies and Bioactivities
- Plant Molecular Biology Research
- PI3K/AKT/mTOR signaling in cancer
- Genetics, Aging, and Longevity in Model Organisms
- Estrogen and related hormone effects
- Steroid Chemistry and Biochemistry
University of Copenhagen
2021-2024
Institute of Cell Biology and Neurobiology
2021
University Medical Center Hamburg-Eppendorf
2019
Universität Hamburg
2019
Nutrition is one of the most important influences on growth and timing maturational transitions including mammalian puberty insect metamorphosis. Childhood obesity associated with precocious puberty, but assessment mechanism that links body fat to early maturation unknown. During development, intake nutrients promotes signaling through insulin-like systems govern cells tissues also regulates timely production steroid hormones initiate juvenile-adult transition. We show here dietary lipid...
Abstract Sensory circuits are typically established during early development, yet how circuit specificity and function maintained organismal growth has not been elucidated. To gain insight we quantitatively investigated synaptic connectivity in the Drosophila nociceptive network larval development. We show that between primary nociceptors their downstream neurons scales with animal size. further identified conserved Ste20-like kinase Tao as a negative regulator of required for maintenance...
Summary Cells and organisms adjust their growth based on the availability of cholesterol, which is essential for cellular functions. However, mechanisms by cells sense cholesterol levels translate these into signals are not fully understood. We report that rapidly activates master growth-regulatory TOR pathway in Drosophila tissues. identify nuclear receptor HR3, an ortholog mammalian RORα, as factor cholesterol-induced activation. demonstrate HR3 binds promotes activation through a...
<title>Abstract</title> Cells and organisms adjust their growth based on the availability of cholesterol, which is essential for cellular functions. However, mechanisms by cells sense cholesterol levels translate these into signals are not fully understood. We report that rapidly activates master growth-regulatory TOR pathway in <italic>Drosophila</italic>tissues. identify nuclear receptor HR3, an ortholog mammalian RORα, as factor cholesterol-induced activation. demonstrate HR3 binds...
ABSTRACT Nutrition is one of the most important influences on growth and timing developmental maturation transitions including mammalian puberty insect metamorphosis. Childhood obesity associated with precocious puberty, but assessment mechanism that links body fat to early unknown. During development, intake nutrients promotes signaling through insulin-like systems govern cells tissues also regulates timely production steroid hormones initiate juvenile-adult transition. We show here dietary...
Abstract Sensory circuits are typically established during early development, yet how circuit specificity and function maintained organismal growth has not been elucidated. To gain insight we quantitatively investigated synaptic connectivity in the Drosophila nociceptive network larval development. We show that between primary nociceptors their downstream neurons scales with animal size. further identified conserved Ste20-like kinase Tao as a negative regulator of required for maintenance...
Nutrition is one of the most important influences on growth and timing developmental maturation transitions including mammalian puberty insect metamorphosis. Childhood obesity associated with precocious puberty, but assessment mechanism that links body fat to early unknown. During development, intake nutrients promotes signaling through insulin-like systems govern cells tissues also regulates timely production steroid hormones initiate juvenile-adult transition. We show here dietary lipid...