A5074654842- Rheumatoid Arthritis Research and Therapies
- Pharmacological Effects of Natural Compounds
- Peripheral Neuropathies and Disorders
North-Western State Medical University named after I.I. Mechnikov
2021
The JAK inhibitor tofacitinib (TOFA) blocks the intracellular signaling pathway that activates synthesis of cytokines and mediators involved in development pain central sensitization (CS), which determines rapid analgesic effect. However, it is not clear how reduction associated with achieving low activity rheumatoid arthritis (RA). aim study was to assess relationship between early clinical response a decrease after 3 6 months. Material methods. group consisted 88 RA patients (age – 53±11.5...
Background: JAK inhibitors block intracellular signaling pathways responsible for the synthesis of cytokines and mediators involved in development chronic pain central sensitization (CS). This determines a very rapid clinical response to inhibitors. However, it is not clear how significant reduction first weeks therapy associated with achievement low rheumatoid arthritis (RA) activity. Objectives: assess relationship between early tofacitinib decrease RA activity after 3 6 months. Methods:...