A5086020407- Rheumatoid Arthritis Research and Therapies
- Toxin Mechanisms and Immunotoxins
- Systemic Lupus Erythematosus Research
- Viral Infections and Immunology Research
- Spondyloarthritis Studies and Treatments
- Healthcare Systems and Public Health
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Pharmacological Effects of Natural Compounds
- Gout, Hyperuricemia, Uric Acid
- Peripheral Neuropathies and Disorders
- Bone health and osteoporosis research
- Human Health and Disease
- Acute Myocardial Infarction Research
- Pediatric health and respiratory diseases
- Sarcoidosis and Beryllium Toxicity Research
- Biosimilars and Bioanalytical Methods
- Medical and Biological Sciences
- Neurological Disorders and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal Disorders and Rehabilitation
- Cancer-related molecular mechanisms research
- Celiac Disease Research and Management
- Education and Professional Development
Petrozavodsk State University
2009-2021
The article considers the results of an international multicenter randomized clinical trial efficacy and safety brand-name drug rituximab (MabThera), a monoclonal antibody against CD20 antigen B cells, its biosimi-lar (Acellbia®) (the BIORA study) in patients with rheumatoid arthritis (RA) refractory to therapy tumor necrosis factor- а inhibitors. Objective: provide evidence for therapeutic equivalence Acellbia® MabThera® also assess their interchangeability. Subjects methods. enrolled adult...
NiSpAR is a non-interventional, multicenter study whose aim was to describe cohort of patients with non-radiological axial spondyloarthritis (nr-axSpA) and approaches its diagnosis in the Russian Federation. Material methods. The involved 20 research centers different regions work consisted two phases: retrospective data collection 12 months before enrolment prospective observation whom nr-axSpA confirmed (104 weeks). included 272 who met inclusion exclusion criteria (Full Analysis Set,...
Rheumatoid arthritis (RA) is an inflammatory rheumatic disease associated with a dysfunction of the T cell-mediated tolerance and leading to disability working population. The regulatory CD4' cells play important role in regulation autoimmunity can suppress immune responses. With that, there no consensus on content these lymphocytes their pathogenesis RA. Objective: aim study was assess ofperipheral blood Tcells (Treg) according expression membrane markers CD4, CD25, CD127 intracellular...
The Russian biotechnological company «BIOCAD» has designed a chimeric monoclonal antibody against CD20 (BCD-020, Acellbia®) that is biosimilar of rituximab (RTM; MabThera®, F. Hoffmann-La Roche Ltd., Switzerland). In recent years, there been evidence RTM can be used at lower doses than those given in the standard recommendations and instructions for use this drug. This serves as basis BCD-020-4/ALTERRA (ALTErnative Rituximab regimen Rheumatoid Arthritis) trial, objective which was to...
Review on a problem of the development atrial fibrillation in patients with thyrotoxicosis is presented. Thyrotoxicosis one most frequent endocrine diseases, conceding only to diabetes mellitus. The reasons hyperthyroidism are Graves’ disease and functional thyroid autonomy. authors give an analysis data cardiac effects thyrotoxicosis, features heart remodeling under influence hyperfunction, prevalence depending age, as well possibility restoring sinus rhythm combination these diseases....
Psoriatic arthritis (PsA) is a chronic immunoinflammatory disease of the joints, spine and entheses from group spondyloarthritis, which usually observed in patients with psoriasis. In recent years, axial form PsA (axPsA) has been actively researched. However, there insufficient data on approaches to diagnosis treatment axPsA real-life clinical practice. This article presents results an interim analysis non-interventional multicenter observational study practice (NiSaXPA) Russian centers....
The JAK inhibitor tofacitinib (TOFA) blocks the intracellular signaling pathway that activates synthesis of cytokines and mediators involved in development pain central sensitization (CS), which determines rapid analgesic effect. However, it is not clear how reduction associated with achieving low activity rheumatoid arthritis (RA). aim study was to assess relationship between early clinical response a decrease after 3 6 months. Material methods. group consisted 88 RA patients (age – 53±11.5...
Objective: to study the rate of metabolic syndrome (MS) and its components among gout patients in different regions Russian Federation. Subjects methods. This cross-sectional multicenter enrolled 2277 patients, including 1963 (86.2%) men 314 (13.8%) women, from 12 independent medical centers The over 18 years age who met classification criteria for gout, elaborated by S. Wallace et al., were included. diagnosis MS was established on basis Adult Treatment Panel III (ATP III) criteria....
Non-coding RNAs play an important role in the regulation of innate and adaptive immune system both health development various pathologies, including autoimmune diseases. Some non-coding have been identified as promising biomarkers for rheumatoid arthritis diagnosis. However, many issues related to mechanism action, well features their functioning during interaction with drugs, still remain unresolved. In this study new data about long BALACAT1, DANCR1, MALAT1 GAS5 expression peripheral blood...
Objective : The aim of the NiSaXPA study is to evaluate quality diagnosing, socio-demographic characteristics and treatment tactics patients with axial psoriatic arthritis (axPsA) in real-world clinical practice Russian Federation. Material methods . involved 600 from 21 centers Results discussion. diagnosis axPsA was confirmed 357 (59.5%) according centralized expert assessment. All lesions met criteria guidelines for PsA. Of these, 201 (69%) had radiologically significant sacroiliitis (SI)...
Objective: to describe the portrait of a patient with rheumatoid arthritis (RA) in real clinical practice, assess disease activity from point view physician and patient, functional status, quality life (QOL), efficiency therapy performed. Patients methods . The investigation enrolled 976 RA patients cohort TERMINAL-I multicenter study, who, when visiting rheumatologist, independently assessed QOL using computer system (the «Computer Terminals SelfAssessment for Rheumatic Diseases» project)....
Actuality of cardiovascular diseases today determines the high interest to study pathogenesis atherosclerosis and searching new risk factors which could help optimize primary secondary prevention. Study correlation between biomarkers inflammation traditional (TRF) in patients with different forms ischemic heart disease is really important today. Aim. To determine TRF level endothelial dysfunction acute coronary syndrome (ACS). Material methods. Patients (n=62) aged from 24 50 years (mean age...
The article is devoted to one of the topical issues contemporary health care — acute coronary syndrome (ACS). objective study was evaluate patients who were treated at Regional Vascular Center during hospital phase treatment and analyze outpatient. Besides, analyses patients’ compliance, long-term clinical social consequences syndrome.
The emergence of new means administering genetically-engineered biological drugs, such as an autoinjector (pen injector device), can positively affect the organizational aspects treating patients with severe eosinophilic asthma (SA) who need therapy. aim . To determine place a delivery device for benralizumab (autoinjector, pen device) in clinical practice SA. Results. expert council considered results latest studies and real data on use drugs form autoinjector. experts discussed safety...
The paper considers the problem of secondary amyloidosis that more frequently occurs in patients with various arthritides, both seropositive and seronegative. According to data available literature, most common manifestations are involvements kidney, liver, nervous system, and, less frequently, lung. authors describe their own observation rheumatoid arthritis, which is accompanied by involvement lung, intestine, resulting fatal outcome. lifetime diagnosis was histologically verified.
Features of diagnostics and course anemic syndrome in rheumatoid arthritis patients Objective. To study features (RA) pts, to estimate influence disease modifying anti – rheumatic drug therapy efficacy on the syndrome. Material methods. 62 pts with definite RA level hemoglobin less than 130g\l for men 120g\l women were examined. Research hemoglobin, red cells count, mean corpuscular volume (MCV), concentration (MCH), serum iron ferritin was carried out. In a part transferrin receptor...
Objective: to estimate the incidence of diabetes mellitus (DM) in patients with rheumatoid arthritis (RA) Republic Karelia and analyze types carbohydrate metabolism disorders. Patients methods . The investigation enrolled 889 aged 18 years older RA treated Rheumatology Department, V.A. Baranov Republican Hospital (Petrozavodsk), 2000 2019. Among them, there were 709 (79.8%) women 180 (20.2%) men; median age was 59 [52; 66] years; duration 6.5 [1.75; 13] years. Most found have positive factor...
Janus kinase (JK) inhibitors block the intracellular signaling pathways that are responsible for synthesis of proinflammatory cytokines and mediators, which in turn cause activation pain receptors central sensitization (CS). It is suggested JK can rapidly eliminate reduce severity CS. Objective : to evaluate effect inhibitor tofacitinib (TOFA) on intensity signs CS patients with active rheumatoid arthritis (RA) at 7 28 days after therapy initiation. Patients methods . A study group consisted...
Background: The presence of central sensitization (CS) significantly burdens the course rheumatoid arthritis (RA). JAK inhibitors block intracellular signal pathways including ones responsible for synthesis mediators and cytokines causing pain CS. application is supposed to relieve reduce CS severity promptly. Objectives: To evaluate inhibitor effect on signs in patients with active RA 7 28 days after start therapy. Methods: Study group included 39 RA, their age was 50.9±11.1, 79.5% women,...
Background: JAK inhibitors block intracellular signaling pathways responsible for the synthesis of cytokines and mediators involved in development chronic pain central sensitization (CS). This determines a very rapid clinical response to inhibitors. However, it is not clear how significant reduction first weeks therapy associated with achievement low rheumatoid arthritis (RA) activity. Objectives: assess relationship between early tofacitinib decrease RA activity after 3 6 months. Methods:...