A5034524656- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Sclerosis and Related Diseases
- Toxin Mechanisms and Immunotoxins
- Dermatologic Treatments and Research
- Skin Diseases and Diabetes
- Sarcoidosis and Beryllium Toxicity Research
- Therapeutic Uses of Natural Elements
The First Republican Clinical Hospital of the Ministry of Health of the Udmurt Republic
2023-2025
Izhevsk State Medical Academy
2023-2025
Consultative and Diagnostic Center
2023
Kazan State Medical University
2023
The search for new therapeutic options the treatment of systemic sclerosis (SSc) is an urgent issue in rheumatology. article presents results double-blind, randomized, placebo-controlled phase III clinical trial BCD-132-5/LIBERIUS on efficacy and safety divozilimab (BCD-132) SSc. Objective : to investigate patients with SSc compared placebo. Material methods . After enrolment study, received or placebo 48 weeks, after which they were switched open-label therapy until week 96. Results...
The aim of the study – to analyze effectiveness and tolerability subcutaneous methotrexate (sc MTX) (Metorthrit; S.C. Rompharm Company S.R.L) in patients with rheumatoid arthritis (RA) high disease activity rapid dose escalation, assess their quality life (QoL) real clinical practice. Material methods . included 105 patients, mostly women, a reliable diagnosis RA (DAS-28 (Disease Activity Score 28) ≥5.1) aged 18 years older ineffectiveness previous oral MTX therapy for at least 6 months or...
Objective: To study the efficacy and safety of olokizumab (OKZ) in patients with rheumatoid arthritis (RA) real-life clinical practice. Material methods. The observational program was conducted 73 centers across Russia from Dec 1, 2022 to Jan 31, 2025. It based on a retrospective analysis real practice data. Information collected analyzed at baseline after 6, 12 months treatment. Results discussion. A total 1,576 (81.7% women) RA, aged 55.0 [44.0; 63.0] years RA duration 100.0 [50.0; 156.0]...
NiSpAR is a non-interventional, multicenter study whose aim was to describe cohort of patients with non-radiological axial spondyloarthritis (nr-axSpA) and approaches its diagnosis in the Russian Federation. Material methods. The involved 20 research centers different regions work consisted two phases: retrospective data collection 12 months before enrolment prospective observation whom nr-axSpA confirmed (104 weeks). included 272 who met inclusion exclusion criteria (Full Analysis Set,...
Psoriatic arthritis (PsA) is a chronic immunoinflammatory disease of the joints, spine and entheses from group spondyloarthritis, which usually observed in patients with psoriasis. In recent years, axial form PsA (axPsA) has been actively researched. However, there insufficient data on approaches to diagnosis treatment axPsA real-life clinical practice. This article presents results an interim analysis non-interventional multicenter observational study practice (NiSaXPA) Russian centers....
The efficacy and safety of levilimab (LVL) in patients with active rheumatoid arthritis (RA) has been confirmed controlled clinical trials. This article presents the results a preliminary analysis non-interventional observational study LVL RA patients. Objective: to evaluate treatment real-world practice. Materials methods. HELIOS is retrospective-prospective, multicenter, retention rate therapy Patients received medical care, including LVL, according routine practice for Russian...
Objective : validation of the Russian-language version Ankylosing Spondylitis Quality Life (ASQoL) specific questionnaire for patients with ankylosing spondylitis (AS). Materials and methods . Тhe study included 100 a definite diagnosis AS according to modified New York criteria 1984. Patients were mostly men (58.5%), average age – 38.6±10 years, disease duration 10.3±7.0 median activity by ASDAS-CRP 2.32 [1.45; 2.94]. At initial visit after 3 months, all underwent standard rheumatological...
Objective : The aim of the NiSaXPA study is to evaluate quality diagnosing, socio-demographic characteristics and treatment tactics patients with axial psoriatic arthritis (axPsA) in real-world clinical practice Russian Federation. Material methods . involved 600 from 21 centers Results discussion. diagnosis axPsA was confirmed 357 (59.5%) according centralized expert assessment. All lesions met criteria guidelines for PsA. Of these, 201 (69%) had radiologically significant sacroiliitis (SI)...
Introduction. Chronic pain consists of nociceptive, neuropathic and nociplastic components. Nociplastic based on central sensitization. Patients with sensitization may experience severe even no any signs clinical laboratory inflammation, describe it in descriptors pain. The prevalence influence activity, the development mood disorders patients psoriatic arthritis are not explored well. Aim. To assess arthritis, to compare parameters without Materials methods. We examined 107 arthritis:...
The article reports the problems of sacroiliitis and spondylitis in patients with ankylosing psoriatic arthritis. Based on concept primary involvement sacroiliac joint inflammation, they are most often is object investigations. But inflammatory changes also affect spine that’s called spondylitis. Due to widespread introduction medical imaging, scientists know various variants axial characteristic spondylopathies: angular (Romanus lesion) non-angular (Andersson lesion, osteitis arch,...