A5014353069- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Drug-Induced Hepatotoxicity and Protection
- MicroRNA in disease regulation
- Physical Education and Training Studies
- Hippo pathway signaling and YAP/TAZ
- Inflammatory Bowel Disease
- Extracellular vesicles in disease
- Pharmacological Effects of Natural Compounds
- Sports Science and Education
- Biochemical effects in animals
- RNA Interference and Gene Delivery
- Rheumatoid Arthritis Research and Therapies
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Kruppel-like factors research
- Protein Tyrosine Phosphatases
- Spondyloarthritis Studies and Treatments
- Sirtuins and Resveratrol in Medicine
- Human Health and Disease
- Biomarkers in Disease Mechanisms
- Diet, Metabolism, and Disease
- Psoriasis: Treatment and Pathogenesis
- Ferroptosis and cancer prognosis
- Systemic Lupus Erythematosus Research
Volgograd State Medical University
2016-2022
Roswell Park Comprehensive Cancer Center
2020-2021
Federal Medical-Biological Agency
2020
University of Rochester
2015-2020
Amita Health St. Mary's Hospital
2019
Ministry of Health of the Russian Federation
1996
Lomonosov Moscow State University
1996
Institute of Molecular Genetics
1996
SIRT6 is an important member of sirtuin family that represses inflammation, aging and DNA damage, three which are causing factors for endothelial dysfunction. expression decreased in atherosclerotic lesions from ApoE(-/-) mice human patients. However, the role regulating vascular function atherosclerosis not well understood. Here we show protects against dysfunction atherosclerosis. Global endothelium-specific knockout exhibited impaired endothelium-dependent vasorelaxation. Moreover,...
Abstract Aims Recent genome-wide association studies (GWAS) have identified that the JCAD locus is associated with risk of coronary artery disease (CAD) and myocardial infarction (MI). However, mechanisms whereby candidate gene confers remain unclear. We addressed whether how affects development atherosclerosis, common cause CAD. Methods results By mining data in Genotype-Tissue Expression (GTEx) database, we found CAD-associated variants at are linked to increased expression human arteries,...
Rationale:Atherosclerosis is a chronic inflammatory and epigenetic disease that influenced by different patterns of blood flow.However, the mechanism whereby atheroprotective flow controls endothelial gene programming remains elusive.Here, we investigated possibility alters expression through mechanisms.Methods: En face staining western blot were used to detect protein expression.Real-time PCR was determine relative expression.RNA-sequencing human umbilical vein cells treated with siRNA...
Kruppel-like factor 2 (KLF2) is an important zinc-finger transcription that maintains endothelial homeostasis by its anti-inflammatory, -thrombotic, -oxidative, and -proliferative effects in cells. In light of the potent vasoprotective KLF2, modulating KLF2 expression or function could give rise to new therapeutic strategies treat cardiovascular diseases.High-throughput drug screening based on promoter luciferase reporter assay was performed screen activators. Real-time PCR western blot were...
The transcription factor Kruppel-like 2 (KLF2) is a critical anti-inflammatory and anti-atherogenic molecule in vascular endothelium. Enhancing KLF2 expression activity improves endothelial function prevents atherosclerosis. However, the pharmacological molecular regulators for are scarce. Using high-throughput luciferase reporter assay to screen activators, we have identified tannic acid (TA), polyphenolic compound, as potent activator that attenuates inflammation. Mechanistic studies...
Significance Endothelial sprouting is critical for both physiological and pathological angiogenesis. However, the molecular mechanisms underlying precise regulation of endothelial have not been fully understood. Here we show that transcription factor Yin Ying 1 (YY1) functions as a repressor Notch signaling through its inhibition intracellular domain protein/mastermind-like protein 1/recombination signal binding Ig Kappa J region complex formation modulates cell tip-stalk fate determination....
Exosomes, including human melanoma-derived exosomes (HMEX), are known to suppress the function of immune effector cells, which for HMEX has been associated with surface presence checkpoint ligand PD-L1. This study investigated relationship between BRAF mutational status melanoma cells and inhibition secreted on antigen-specific T cells. Exosomes were isolated from two cell lines, 2183-Her4 888-mel, genetically wild-type BRAFWT BRAFV600E, respectively. using a modified, size-exclusion...
AIM: to demonstrate the first Russian experience with use of tofaciminib (TOFA) for treatment moderate and severe UC in real clinical practice. PATIENTS AND METHODS: eighty-five patients (aged 41.38±14.69 years, average disease duration 9.55±5.27 mild – 3.5%, 41.2%, 52.9%, acute 2.6%), resistant corticosteroid therapy (36.5%) biological agents (61.2%), were prescribed TOFA at an induction dose 10 mg 2 times a day, followed by decrease maintenance (5 day). Early response, endoscopic...
Objective: to study the rate of metabolic syndrome (MS) and its components among gout patients in different regions Russian Federation. Subjects methods. This cross-sectional multicenter enrolled 2277 patients, including 1963 (86.2%) men 314 (13.8%) women, from 12 independent medical centers The over 18 years age who met classification criteria for gout, elaborated by S. Wallace et al., were included. diagnosis MS was established on basis Adult Treatment Panel III (ATP III) criteria....
Introduction: Impaired activation of endothelial nitric oxide (NO) synthase (eNOS) and ensued NO production is a common mechanism various cardiovascular pathologies, including hypertension atherosclerosis. Specific signaling cascades, generated by vascular cells (ECs) in response to laminar flow, modulate EC structure functions, particular. We have previously shown that flow-stimulated Gab1 (Grb2-associated binder-1) tyrosine phosphorylation mediates eNOS activation. However, the upstream...
Objective: We have previously shown that docking protein Grb2-associated binder 1 (Gab1) is a mechano-effector in response to fluid shear stress and regulates postnatal angiogenesis. The aim of this study was determine the vivo role endothelial Gab1 flow-mediated vascular remodeling atherosclerosis explore underlying mechanisms. Methods Results: To disturbed flow-induced vivo, we performed partial carotid artery ligation endothelium-restricted knockout (Gab1-ecKO) mice wild-type (WT)...