A5004451777- Research on Leishmaniasis Studies
- Immunotherapy and Immune Responses
- Insect Pest Control Strategies
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Pharmacological Effects of Natural Compounds
- Toxin Mechanisms and Immunotoxins
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Piperaceae Chemical and Biological Studies
- Cancer-related gene regulation
- Parasites and Host Interactions
- Trypanosoma species research and implications
- Cancer Research and Treatments
- Essential Oils and Antimicrobial Activity
- T-cell and B-cell Immunology
- Phytochemicals and Medicinal Plants
- Leptospirosis research and findings
- Synthesis and bioactivity of alkaloids
- Medicinal Plants and Neuroprotection
- Xenotransplantation and immune response
- vaccines and immunoinformatics approaches
- Prostate Cancer Treatment and Research
- Immune cells in cancer
- Extracellular vesicles in disease
Roswell Park Comprehensive Cancer Center
2017-2023
Department of Biotechnology
2014-2021
Jamia Hamdard
2011-2021
Translational Health Science and Technology Institute
2016
Hamdard University
2015
Nanoliposomal artemisinin for the treatment of murine visceral leishmaniasis Muzamil Y Want,1 Mohammad Islammudin,1 Garima Chouhan,1 Hani A Ozbak,2 Hassan Hemeg,2 Asoke P Chattopadhyay,3 Farhat Afrin2 1Parasite Immunology Laboratory, Department Biotechnology, Jamia Hamdard, Hamdard University, New Delhi, India; 2Department Clinical Laboratory Sciences, Faculty Applied Medical Taibah Medina, Saudi Arabia; 3Department Chemistry, University Kalyani, India Abstract: Visceral (VL) is a fatal,...
The therapy of visceral leishmaniasis (VL) is limited by resistance, toxicity and decreased bioavailability the existing drugs coupled with dramatic increase in HIV-co-infection, non-availability vaccines down regulation cell-mediated immunity (CMI). Thus, we envisaged combating problem plant-derived antileishmanial drug that could concomitantly mitigate immune suppression infected hosts. Several compounds have been found to exert leishmanicidal activity via immunomodulation. In this...
There is a pressing need for drug discovery against visceral leishmaniasis, life-threatening protozoal infection, as the available chemotherapy antiquated and not bereft of side effects. Plants alternate resources has rewarded mankind in past aimed this direction, we investigated antileishmanial potential Cinnamomum cassia.Dichloromethane, ethanolic aqueous fractions C. cassia bark, prepared by sequential extraction, were appraised their anti-promastigote activity along with...
Exploration of immunomodulatory antileishmanials plant origin is now being strongly recommended to overcome the immune suppression evident during visceral leishmaniasis (VL) and high cost toxicity associated with conventional chemotherapeutics. In accordance, we assessed in vitro vivo antileishmanial potential ethanolic fractions Azadirachta indica leaves (ALE) seeds (ASE). A. were prepared by sequential extraction powdered parts hexane, ethanol water. Erythrosin B staining was employed...
VL is a life-threatening protozoal infection chiefly impinging the rural and poor population in tropical sub-tropical countries. The deadly affliction rapidly expanding after its association with AIDS, swiftly defying status of neglected disease. Despite successful formulation vaccine against canine leishmaniasis, no licensed yet available for human VL, chemotherapy appalling state, development new candidate drugs has been painfully slow. In face lack proper incentives, immunostimulatory...
Immunotherapy in prostate cancer (PCa) lags behind the progresses obtained other types partially because of its limited immune infiltration. Tumor-resident cells have been detected prostate, but regulatory mechanisms that govern tumor infiltration are still poorly understood. To address this gap, we investigated role Wolf-Hirschhorn syndrome candidate 1 (WHSC1), a histone methyltransferase enzyme targets dimethyl and trimethyl H3K36. WHSC1 is known to promote malignant growth progression...
The study was aimed to develop a characterized polyherbal combination as an immunomodulator containing Phyllanthus emblica L., Piper nigrum Withania somnifera (L.) Dunal, and Tinospora cordifolia (Willd.) Miers. Through response surface methodology (RSM), the ratio of aqueous extracts four plant materials optimized comprised 49.76% P. emblica, 1.35% nigrum, 5.41% W. somnifera, 43.43% T. for optimum immunomodulatory activity. showed antioxidant potential contains more than 180 metabolites,...
Ovarian cancer (OC) has an overall modest number of mutations that facilitate a functional immune infiltrate able to recognize tumor mutated antigens, or neoantigens. Although patient-derived xenografts (PDXs) can partially model the mutational load and mimic response chemotherapy, no study profiled neoantigen-driven in OC PDXs. Here we demonstrate genomic status primary from patient be recapitulated vivo PDX model, with goal defining autologous T cells activation by neoantigens using...
Exosomes, including human melanoma-derived exosomes (HMEX), are known to suppress the function of immune effector cells, which for HMEX has been associated with surface presence checkpoint ligand PD-L1. This study investigated relationship between BRAF mutational status melanoma cells and inhibition secreted on antigen-specific T cells. Exosomes were isolated from two cell lines, 2183-Her4 888-mel, genetically wild-type BRAFWT BRAFV600E, respectively. using a modified, size-exclusion...
The current therapeutic armory for visceral leishmaniasis (VL) caused by Leishmania donovani complex is inadequate, coupled with serious limitations. Combination therapy has proved ineffective due to mounting resistance; however, the search safe and effective drugs desirable, in absence of any vaccine. There a growing interest application nanoparticles effectiveness leishmaniasis. Aimed this direction, we assessed antileishmanial effect gold (GNP) against L. vitro.GNP were synthesized...
Immunotherapy initially demonstrated promising results in prostate cancer (PCa), but the modest or negative of many recent trials highlight need to overcome poor immunogenicity this cancer. The design effective therapies for PCa is challenged by limited understanding interface between cells and immune system mediating therapeutic resistance. Prompted our observations that elevated WHSC1, a histone methyltransferase known promote progression numerous cancers, can silence antigen processing...
DNA methylation acts as a major epigenetic modification in mammals, characterized by the transfer of methyl group to cytosine. plays pivotal role regulating normal development, and misregulation cells leads an abnormal phenotype is seen several cancers. Any mutations or expression anomalies genes encoding regulators may lead critical molecules. A comprehensive genomic study encompassing all related regulation relation breast cancer lacking. We used transcriptomic datasets from Cancer Genome...
Abstract Despite significant advances in the treatment of visceral leishmaniasis (VL), conventional chemotherapy (CT) has considerable toxicities and relapses. Immunotherapeutic strategies, aimed to amplify Leishmania-specific immune response prior or synergy with CT may lower required dose duration hence toxicity, improving chemotherapy's overall efficacy, reduce emergence drug resistant strains, circumvent problems immunocompromised hosts. Effective antileishmanial intervention blending...
Abstract Ovarian cancer (OC) is the fifth leading cause of death in United States with approximately 20,000 women being diagnosed every year. Since OC development mainly asymptomatic, patients are often at late stage and present local distal metastases. This offers a clinical challenge, as roughly 70% develop chemoresistant disease. With advent immunogenomics it now possible to identify tumor specific mutations, or neoantigens/neoepitopes, that can be exploited for personalized T cell...
Abstract Ovarian cancer (OC) is the fifth leading cause of death in US, presenting a low mutational burden and diverse degree infiltrating T cells. Neoantigens derived from somatic mutations represent an attractive immunotherapeutic target, however, mouse models for development personalized immunotherapies are still poor do not fully recapitulate individualized nature OC patients. To address this hurdle, our study established patient-derived xenograft (PDX) patient as segue to studying...