A5077226721- Rheumatoid Arthritis Research and Therapies
- Helicobacter pylori-related gastroenterology studies
- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Health, psychology, and well-being
- Autoimmune and Inflammatory Disorders Research
- Empathy and Medical Education
- Inflammasome and immune disorders
- Cardiovascular Disease and Adiposity
- GDF15 and Related Biomarkers
- Systemic Lupus Erythematosus Research
- Eosinophilic Esophagitis
- Monoclonal and Polyclonal Antibodies Research
- Cardiovascular Effects of Exercise
- Pathogenesis and Treatment of Hiccups
- Biosimilars and Bioanalytical Methods
- Neurological Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Biochemical effects in animals
- Chronic Kidney Disease and Diabetes
- Chronic Lymphocytic Leukemia Research
- Gastroesophageal reflux and treatments
- Cardiovascular and exercise physiology
- Healthcare Systems and Public Health
Kemerovo State Medical Academy
2017-2024
Kemerovo Cardiology Center
2019-2021
Ministry of Health of the Russian Federation
2017
The aim – to evaluate the clinical effectiveness, safety, pharmacokinetics, pharmacodynamics, and immunogenicity of seniprutug (BCD-180) in patients with radiographic active axial spondyloarthritis (r-axSpA, or ankylosing spondylitis). Subjects methods . 260 r-axSpA inadequate response nonsteroidal anti-inflammatory drugs (NSAIDs) were randomized into three groups: at doses 5 mg/kg 7 mg/kg, placebo. BCD-180 was administered on weeks 0–12–36. Patients placebo group switched a dose week 24...
Levilimab is anti-interleukin-6 receptor (IL6R) monoclonal antibody. The article presents data obtained during 24 weeks of the SOLAR phase III study. Objective : to confirm efficacy and safety levilimab in combination with methotrexate (MTX) patients resistant active rheumatoid arthritis (RA). Patients methods . 154 adult patients, aged ≥18 years diagnosis RA (ACR/EULAR 2010) confirmed disease activity at screening despite treatment MTX for least 12 (in a stable dose 15-25 mg/week). were...
The Russian biotechnological company «BIOCAD» has designed a chimeric monoclonal antibody against CD20 (BCD-020, Acellbia®) that is biosimilar of rituximab (RTM; MabThera®, F. Hoffmann-La Roche Ltd., Switzerland). In recent years, there been evidence RTM can be used at lower doses than those given in the standard recommendations and instructions for use this drug. This serves as basis BCD-020-4/ALTERRA (ALTErnative Rituximab regimen Rheumatoid Arthritis) trial, objective which was to...
Background . Previously, 24-week results of phase III double-blind, placebo-controlled randomized clinical study (SOLAR) levilimab in subjects with active rheumatoid arthritis (RA) proved a superiority over placebo. Here we present 1-year efficacy and safety data the SOLAR study. Objective – to evaluate combination methotrexate (MTX) MTX resistant RA. Methods The was conducted at 21 sites Russia Belarus. All have completed between November 2019 October 2021.154 adults, aged ≥18 years...
Научно-практическая ревматология.2019;57(6):668-677 О р и г н а л ь ы е с д о в я 1 ФГБНУ «Научно-исследовательский институт ревматологии им.В.А.Насоновой», Москва, Россия; 2 ФГБОУ ВО «Северо-Западный государственный медицинский университет им.И.И.Мечникова» Минздрава России, Санкт-Петербург, 3 «Казанский университет» Казань, 4 ГАУЗ НСО «Городская клиническая поликлиника №1», Новосибирск, 5 НУЗ «Отделенческая больница на станции Смоленск ОАО «РЖД», Смоленск, 6 ГБУЗ НО «Нижегородская...
Aim . To study the associations between attitude towards illness and level of compliance in patients with chronic gastritis. Materials Methods The included 302 gastritis which have been stratified into 4 groups: 1) 96 Helicobacter pylori (HP)-associated high treatment adherence; 2) 110 HP-negative 3) 36 HP-associated who refused treatment; 4) 60 moderate adherence. adherence to personal response disease was assessed using Davydov TOBOL questionnaires, respectively. Interrelations studied...
Aim. To assess the specifics of myocardium remodeling in sportsmen-weightlifters according to presence arterial hypertension (AH). Material and methods. Totally 80 were included at age 21,0 (18,5-25,0) years. Group AH consisted 42 (52,5%) men, group without — 38(47,5%). Investigation office BP measurement, ambulatory monitoring (ABPM), echocardiography (EchoCG). Results. In with index left ventricle myocardial mass (ILVMM), atrium sizes (LA), end-diastolic size (EDS), thickness...
THE AIM. Compare cognitive performance in patients with CKD not receiving HD and on HD. PATIENTS AND METHODS. The study included of young middle age (from 18 to 60 years) (n = 40) who have stage 5 chronic kidney disease (CKD) 40 hemodialysis comparable 58 make up the comparison group. exclusion criteria for both groups were: a history diseases central nervous system; brain injury; episodes cerebral circulation varying severity; coronary heart disease; failure; pregnancy; alcohol abuse;...
Abstract. Aim: to study the relationship between level of adherence treatment patients with chronic gastritis and psychological characteristics severity stress. Materials methods. 302 (CG) were examined, which, de-pending on treatment, included in 4 groups: group 1 - 96 HG associated H.pylori (HP); 2 110 hepatitis not HP. In these groups, compliance was observed be high. Group 3 formed from 36 CG HP who refused (low compliance), 60 diagnosed HP, partially complied doctor's recommendations...
The aim of the research. To study influence empathic care level provided by attending physician on chronic gastritis patients’ adherence to treatment and therapy effectiveness. Material methods. A total 302 patients with were examined. Depending treatment, divided into 4 groups. Group 1: 96 associated H. pylori; group 2: 110 not pylori. Patients in these groups had a high adherence. 3 was formed from 36 pylori who rejected treatment; included 60 partially adhered physician’s recommendations....
Aim . To study the associations between empathy, anxiety, and compliance in patients with chronic gastritis. Materials Methods Here we recruited 302 gastritis, further stratifed into 4 groups: 1) 96 H. pylori-associated gastritis high compliance; 2) 110 negative for Helicobacter pylori also having 3) 36 low 4) 60 partial compliance. Empathy was evaluated using Consultation Relational Measure (CARE Measure) questionnaire, whilst anxiety determined Spielberger-Khanin questionnaire. Results The...