A5013810815- Pickering emulsions and particle stabilization
- Mesoporous Materials and Catalysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Polyoxometalates: Synthesis and Applications
- Nanoparticles: synthesis and applications
- Nanoplatforms for cancer theranostics
- Metal-Organic Frameworks: Synthesis and Applications
- Polymer Surface Interaction Studies
- Nanomaterials and Printing Technologies
- Transition Metal Oxide Nanomaterials
- Surfactants and Colloidal Systems
- Catalysis and Oxidation Reactions
- Advanced Nanomaterials in Catalysis
- Membrane Separation and Gas Transport
- Aerogels and thermal insulation
- Photonic Crystals and Applications
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- Electrostatics and Colloid Interactions
- Supercapacitor Materials and Fabrication
- Nanocluster Synthesis and Applications
- Crystallization and Solubility Studies
- Catalytic Processes in Materials Science
- Covalent Organic Framework Applications
- Drug Solubulity and Delivery Systems
Laboratoire Matière et Systèmes Complexes
2015-2024
Université Paris Cité
2015-2024
Centre National de la Recherche Scientifique
2015-2024
Sorbonne Paris Cité
2016-2024
Délégation Paris 7
2010-2021
Délégation Paris 6
2018-2020
Metric Systems Corporation (United States)
2020
Paul Pascal Research Center
2004-2018
Center for Research in Psychopathology and Clinical Psychology
2009-2018
Université de Bordeaux
2009-2018
Gold nanoparticles are used in an expanding spectrum of biomedical applications. However, little is known about their long-term fate the organism as it generally admitted that inertness gold prevents biodegradation. In this work, biotransformations captured by primary fibroblasts were monitored during up to 6 mo. The combination electron microscopy imaging and transcriptomics study reveals unexpected 2-step process biotransformation. First, there degradation nanoparticles, with faster...
Hierarchical inorganic porous monoliths have been prepared using concentrated emulsion and micellar templates. The texture of these has to be tuned varying either the pH continuous aqueous phase, emulsification process or oil volumic fraction. These materials show interconnected macroporosity associated with vermicular-type mesostructuration. They possess an average mesoporosity 800 m2 g−1 bulk density as low 0.08 g cm−3, which is comparable values obtained for silica aerogel.
The drainage of SiO(2) nanoparticle-cationic surfactant (TTAB) mixtures through calibrated aqueous foams had been studied by combining several approaches on both the macroscopic and local scale. Macroscopic measurements reveal a strong stabilizing effect arising for nanoparticle concentrations as low 2 wt % mainly because kinetic slow-down dependent concentration. We show that variation viscous parameters (bulk viscosity, interfacial or both) in classical theoretical models foam drainage,...
A study integrating advanced experimental and modeling tools was undertaken to characterize the microstructural interfacial properties of mixed matrix membranes (MMMs) composed zeolitic imidazolate framework ZIF-8 nanoparticles (NPs) two polymers intrinsic microporosity (PIM-1 PIM-EA-TB). Analysis probed both initial ZIF-8/PIM-1 colloidal suspensions final hybrid membranes. By combination dynamic light scattering (DLS) transmission electron microscopy (TEM) analytical imaging techniques with...
A microporous Al trimesate-based metal–organic framework (MOF), denoted MIL-96-(Al), was selected as a porous hybrid filler for the processing of mixed matrix membranes (MMMs) CO2/N2 postcombustion separation. First, structural model MIL-96-(Al) initially reported revisited using combination synchrotron-based single-crystal X-ray diffraction, solid-state nuclear magnetic resonance spectroscopy, and density functional theory (DFT) calculations. In second step, pure crystals differing by their...
Proteins implicated in iron homeostasis are assumed to be also involved the cellular processing of oxide nanoparticles. In this work, role an endogenous storage protein—namely ferritin—is examined remediation and biodegradation magnetic Previous vivo studies suggest intracellular transfer ions released during degradation nanoparticles protein cages within lysosomal compartments. Here, capacity ferritin accommodate store products is investigated vitro physiological acidic environment...
Extracellular vesicles (EVs) are increasingly envisioned as the next generation of biological pro-regenerative nanotherapeutic agents, has already been demonstrated for heart, kidney, liver, and brain tissues; lung injury repair; skin regeneration. Herein, we explore another potential EV therapeutic application, fistula healing, together with a local minimally invasive delivery strategy. Allogenic extracellular from adipose tissue-derived stromal cells (ASCs) administered in porcine model...
The so-called Graftfast reaction in water and at room temperature (RT) was applied to graft polyethylene glycol (PEG) the surface of microporous zeolitic imidazolate framework ZIF-8 nanoparticles (NPs) using acrylPEG different chain lengths (480 Da 5 kDa). In comparison nonmodified NPs, both chemical colloidal stabilities PEGylated NPs are significantly enhanced water. A series complex fluids by mixing PEG grafted (i.e., PEG-g-ZIF-8) with amounts poly(vinyl alcohol) (PVA) prepared...
Peritoneal metastasis (PM) is considered as the terminal stage of metastatic colon cancer, with still poor median survival rate even best recent chemotherapy treatment. The current PM treatment combines cytoreductive surgery, which consists resecting all macroscopic tumors, hyperthermic intraperitoneal (HIPEC), uses mild hyperthermia to boost diffusion and cytotoxic effect chemotherapeutic drugs. As HIPEC performed via a closed circulation hot liquid containing chemotherapy, it induces...
We report a novel superparamagnetic stimuli-responsive nano-object coupling MIL-100(Fe) and maghemite, which, once combined with two complementary drugs (MTX Dox), leads to multifunctional theranostic platform treat inflammatory diseases.
We designed a novel class of anti-inflammatory nanomedicines. It exhibited high cytotoxicity to activated macrophages was able reduce the secretion pro-inflammatory cytokines and inhibit Toll-like receptor signaling cascade.
A technique that uses a non‐static patterning method has been employed for rational design toward macrocellular silica scaffolds (see Figure). The allows complete control over the width, length, and curvature of plateau borders foam. Furthermore, this macroscale void space structuration is associated with secondary micro‐ mesoscale porosity thus reaching hierarchically organized monolith‐type materials.
Abstract Fe 3 O 4 nanocrystals are self‐assembled into two different conformations: colloidosome and supraball that confer them with distinct properties determining their photo‐induced heating capacities. These self‐assemblies assessed for photothermal therapy, an adjuvant strategy tumor therapy. The microenvironment is a heterogeneous ecosystem including immune cells the extracellular matrix. interactions between therapy agents components of determine outcome this In study, fate both...
Titania foams (see Figure) can be produced using a non-static air–liquid foaming sol–gel process where nitrogen is bubbled through mixture of surfactant and precursor. Either anatase or rutile phase mesoporous titania are upon thermal treatment. Macroscopic cell morphologies tuned by changing the air-to-liquid-foam ratios size bubbles, while wall topologies varied surfactant. Supporting information for this article available on WWW under...
Interactions of plant tannins with polysaccharide hyaluronan are studied by means light scattering and small-angle X-ray (SAXS). In this paper, we show that (1) the tannin–polysaccharide complexes remain stable in colloidal suspension; (2) masses structures objects depend on tannin degree polymerization; (3) densities aggregates about 7 times lower than density a single solvated molecule. Short polysaccharides aggregated loose oligomeric whose sizes comparable to Tannins longer 10 nm larger...
Polyethyleneimine-assisted one-pot synthesis of gold nanoparticles that self-arrange into fractal nanoaggregates and demonstrate photo-thermal therapeutic imaging efficiency.
A novel strategy is proposed to synthesize metal–organic framework (MOF)–gelatin bionanocomposites by taking profit of the thermo-reversible character gelatin and liquid–liquid phase separation process, that is, coacervation. This enables formation based on a series chemically stable Zr4+ dicarboxylate MOFs (UiO-66 MOF-801) differing their hydrophilic–hydrophobic balance chemical functionality. Bionanocomposites with homogeneous uniform distribution MOF particles in matrix as well high...
Upon a nonstatic patterning method that employs metastable air−liquid foaming process, macroporous vanadium oxide scaffolds have been synthesized. By controlling the foams liquid fraction, process in use allows one to tune size and shape (from spherical more polygonal aspect) as well Plateau-borders thickness of macroscopic void spaces. XRD experiments reveal amorphous character matrices intercalated with surfactant entities, while local structure around atoms, demonstrated 51V NMR MAS...
Cyclodextrins are a family of oligosaccharides with toroid shape that exhibit unique ability entrapping guest molecules in their internal cavity. Water is the primary molecule and omnipresent crystalline phases stabilizing overall architecture. Despite presence water inside cavity, cyclodextrins provide hydrophobic environment where poorly soluble can easily fit. In this investigation we put evidence different types hydrated α-, β-, γ-cyclodextrin crystals. Thermogravimetric measurements...