A5085375625- Metal-Organic Frameworks: Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Dendrimers and Hyperbranched Polymers
- Advanced biosensing and bioanalysis techniques
- Nanoparticles: synthesis and applications
- Covalent Organic Framework Applications
- Telomeres, Telomerase, and Senescence
- Gallbladder and Bile Duct Disorders
- Medical Imaging and Pathology Studies
- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
Adam Mickiewicz University in Poznań
2021-2024
Centre National de la Recherche Scientifique
2017-2023
ESPCI Paris
2021-2023
École Normale Supérieure - PSL
2022-2023
Université Paris Sciences et Lettres
2018-2022
Institut des Matériaux Poreux de Paris
2021
École Normale Supérieure
2021
Institut de Chimie et des Matériaux Paris-Est
2021
Université Paris-Sud
2017-2018
Chimie ParisTech
2017-2018
Abstract Despite high morbidity and mortality associated with lung diseases, addressing drugs towards tissue remains a pending task. Particle filtration has been proposed for passive targeting drug delivery. However, toxicity issues derived from the long‐term presence of particles must be overcome. By exploiting some ignored properties nanosized metal–organic frameworks it is possible to achieve impressive antitumoral effects on experimental tumors, even without need engineer surface...
We report a novel superparamagnetic stimuli-responsive nano-object coupling MIL-100(Fe) and maghemite, which, once combined with two complementary drugs (MTX Dox), leads to multifunctional theranostic platform treat inflammatory diseases.
Abstract Radiolabeling and nuclear imaging techniques are used to investigate the biodistribution patterns of soft hard protein corona around poly (lactic‐co‐glycolic acid) nanoparticles (PLGA NPs) after administration healthy mice. Soft coronas 131 I‐labeled BSA or serum formed on PLGA NPs functionalized with either polyehtylenimine (PEI) bovine albumin (BSA). The exchangeability is assessed in vitro by gamma counting exposing non‐labeled BSA, serum, simulated body fluid. PEI form larger...
In article number 1707365, Patrick Couvreur, Christian Serre, and co-workers evaluate the biomedical applications of metal–organic frameworks at preclinical stage, for pharmacological or toxicity evaluation. Current surface-engineering approaches, in vivo studies, their prospects are considered. The back cover image illustrates circulation drug-loaded MOF nanoparticles a blood vessel. particular, nanosized cages MIL-100(Fe) loaded with Ibuprofen drug represented. Cover project designed by...
Nanoparticles of metal-organic frameworks (MOF NPs) are crystalline hybrid micro- or mesoporous nanomaterials that show great promise in biomedicine due to their significant drug loading ability and controlled release. Herein, we develop porous capsules from aggregate nanoparticles the iron carboxylate MIL-100(Fe) through a low-temperature spray-drying route. This enables concomitant one-pot encapsulation high an antitumor drug, methotrexate, within pores MOF NPs, collagenase enzyme (COL),...
Abstract The timing and location of senescent cells in vivo is a leading candidate explanation for human aging. A rapidly developing scientific field with the potential to slow aging process creation pharmacologically active medicines that target cells. Senotherapeutics have been developed selectively or preferentially eliminate Senolytic compounds delay animal models are being explored humans great hope. Nanoparticle (NP) drug delivery strategies targeting their infancy, but advancements...
Understanding the interplay between nanoparticles (NPs) and cells is essential to designing more efficient nanomedicines. Previous research has shown role of cell cycle having impact on efficiency cellular uptake accumulation NPs. However, there a limited investigation into biological fate NPs in that are permanently withdrawn from cycle. Here we utilize senescent WI-38 fibroblasts, which do not divide provide definitive model for tracking silica (SiNPs) independent We use several methods...
Screening on a relevant 3D tumor model enabled to discard unpromising nanocarriers and may help their opportune optimization successfully reach the target.
Abstract Despite high morbidity and mortality associated with lung diseases, addressing drugs towards tissue remains a pending task. Particle filtration has been proposed for passive targeting drug delivery. However, toxicity issues derived from the long‐term presence of particles must be overcome. By exploiting some ignored properties nanosized metal–organic frameworks it is possible to achieve impressive antitumoral effects on experimental tumors, even without need engineer surface...