ConspectusDirect C–H bond activation is an important reaction in synthetic organic chemistry. This methodology has the potential to simplify reactions by avoiding use of prefunctionalized reagents. However, selectivity, especially site remains challenging. Sequential reactions, which different molecules or groups are combined ordered sequence, represent a powerful tool for construction complex single operation.We have discovered and developed that combines selective with sequential...

Catalytic methods are important tools for the synthesis of C−C bonds under mild and ambient conditions. Palladium chemistry predominates in this area because it offers opportunity to form several different types one pot. can also tolerate a variety functional groups. Among many investigations catalytic aryl−aryl couplings, most successful technique has been Suzuki reaction, which uses an arylboronic acid attack aryl−Pd bond. This Account reports our methodology, based on cooperative action...

In contemporary drug discovery, enhancing the sp

Highly substituted oxygen heterocycles can be prepared in good yields at room temperature by reacting o-(1-alkynyl)-substituted arene carbonyl compounds with NBS, I(2), ICl, p-O(2)NC(6)H(4)SCl, or PhSeBr and various alcohols carbon-based nucleophiles. Naphthyl ketones iodides are readily the reaction of 2-(1-alkynyl)arene-carboxaldehydes I(2) simple olefins alkynes.

Mechanistic questions concerning palladium and norbornene catalyzed aryl-aryl coupling reactions are treated in this paper: how aryl halides react with the intermediate palladacycles, formed by interaction of two catalysts an halide, what is rational explanation "ortho effect" (caused ortho substituent starting halide), which leads to a second molecule halide rather than aryl-norbornyl coupling. Two possible pathways have been proposed, one involving oxidative addition palladacycle, other...

Abstract The reactions of propargyl alcohols with carbon dioxide in supercritical or acetonitrile gaseous the presence organic bases as catalysts have been examined. Bicyclic guanidines are effective for formation α‐methylene cyclic carbonates under mild reaction conditions. Oxoalkyl carbonates, oxoalkyl carbamates α‐methyleneoxazolidinones obtained high yields and good selectivities one‐step starting from an external nucleophile (alcohols amines) using bicyclic dioxide. Propargylic diols...

In this account, we review our efforts in the field of carbonylation reactions promoted by palladium iodide-based catalysts, which have proven to be particularly efficient diverse kinds processes (oxidative carbonylations as well additive and substitutive carbonylations). Particularly case oxidative carbonylations, more emphasis has been given most recent results applications.

Highly substituted 1H-isochromenes, isobenzofurans, and pyranopyridines can be prepared by allowing o-(1-alkynyl)arenecarboxaldehydes ketones to react with I2, ICl, NIS, Br2, NBS, p-O2NC6H4SCl, or PhSeBr various alcohols carbon-based nucleophiles at room temperature. Naphthyl iodides are also readily the reaction of 2-(1-alkynyl)arenecarboxaldehydes I2 simple olefins alkynes.

Expecting the unexpected: The title reaction leads to satisfactory yields of dihydrodibenzoazepines 1 a from norbornene. dibenzoazepines 2 can also be accessed compounds type b when norbornadiene is used as reactant. Theoretical studies show that represents chelation-driven deviation usual selectivity observed in presence ortho-substituents on aryl iodide. Detailed facts importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or...

o-Biaryl carbaldeydes and ketones are obtained through the one-pot reaction of o-aryl iodides with o-bromobenzyl alcohols under catalytic action Pd norbornene, in presence a base. The same can also give dibenzopyrans by norbornene catalysis different termination, leading to C–O ring closure. In both cases process first leads five-membered palladacycle, which controls C–C coupling, then seven-membered oxapalladacycle, gives aldehydes or dibenzopyrans.

Abstract The direct syntheses of ureas, oxamides, 2‐oxazolidinones, and benzoxazolones by the oxidative carbonylation amines, β‐amino alcohols, 2‐aminophenols allows us to obtain high value added molecules, which have a large number important applications in several fields, from very simple building blocks. We found that it is possible perform these transformations using PdI 2 /KI catalytic system an ionic liquid, such as 1‐butyl‐3‐methylimidazolium tetrafluoroborate, solvent,...

Carbon dioxide produced by human activities is one of the main contributions responsible for greenhouse effect, which modifying Earth’s climate. Therefore, post-combustion CO2 capture and its conversion into high value-added chemicals are integral parts today’s green industry. On other hand, carbon a ubiquitous, cheap, abundant, non-toxic, non-flammable renewable C1 source. Among usages, this review aims to summarize discuss advances in reaction CO2, synthesis cyclic carbonates, carbamates,...

An effective and straightforward approach to the synthesis of 4H-3,1-benzoxazines 3 4, quinazolin-2-ones 5, quinoline-4-one derivatives 6 7 is provided by palladium-catalyzed cyclization−alkoxycarbonylation variously substituted 2-(trimethylsilanyl)ethynylaniline amide or urea 2. Reactions are carried out in 7:1 MeCN/MeOH at 65 75 °C presence catalytic amounts 10% Pd/C conjunction with Bu4NI KF under 2.4 MPa a 3:1 mixture CO air. Anti syn 6-exo-dig cyclization modes account for formation two...

Abstract The present paper offers a synthetically simple one‐pot procedure for the catalytic preparation of biologically interesting class carbazoles. new is based on combined catalysis palladium and norbornene starting from o ‐substituted iodoarenes N ‐sulfonylated or ‐acetylated ‐bromoanilines. A well‐known member this class, carbazomycin A, has been successfully prepared.

Abstract Despite the advances in field of carbon‐halogen bond formation, straightforward catalytic access to selectively functionalized iodoaryls remains a challenge. Here, we report one‐pot synthesis ortho ‐iodobiaryls from aryl iodides and bromides by palladium/norbornene catalysis. This new example Catellani reaction features initial cleavage C(sp 2 )−I bond, followed key formation palladacycle through C−H activation, oxidative addition an bromide ultimate restoration bond. A large...

Carbonylation reactions carried out at room temperature and atmospheric pressure of carbon monoxide are highly attractive extremely rare the same time. Here, oxidative alkoxycarbonylation styrenes to industrially relevant cinnamates has been developed under such a mild conditions (rt, 1 atm CO) in presence palladium(II) complex bearing bis(aryl)acenaphthenequinonediimine ligand, benzoquinone p-toluenesulfonic acid. Remarkably, variously substituted styrene derivatives have efficiently...

Carbon dioxide, a primary driver of global warming, offers promising feedstock for valuable chemical synthesis. Nonetheless, the reliance on highly pressurized canisters and specialized equipment limits its practical application in fine This study explores innovative use sodium bicarbonate (NaHCO3) as safe, solid on-demand source CO2 under mechanochemical conditions to perform carboxylation reactions. In one example, we report synthesis cyclic carbamate, enabling more sustainable these...

Carbon dioxide, a primary driver of global warming, offers promising feedstock for valuable chemical synthesis. Nonetheless, the reliance on highly pressurized canisters and specialized equipment limits its practical application in fine This study explores innovative use sodium bicarbonate (NaHCO3) as safe, solid on-demand source CO2 under mechanochemical conditions to perform carboxylation reactions. In one example, we report synthesis cyclic carbamate, enabling more sustainable these...

Photomechanochemistry, i.e., the merger of light energy and mechanical forces, is emerging as a new trend in organic synthesis, enabling unique reactivities fleeting excited states under solvent-minimized conditions. Despite its transformative potential, field faces significant technological challenges that must be addressed to unlock full capabilities. In this Perspective, we analyze selected examples showcase available technologies combine including manual grinding, vortex shaker mixing,...

Abstract: The perlite concrete has generally low compressive strength. Lightweight and thermally efficient is used in construction for its ecological benefits, though it typically offers reduced load-bearing capacity compared to conventional concrete. living planet earth encountered global warming due various issues. Coal power plants produce solid waste called fly ash whose disposal difficult. Therefore, urgent changes are required relating emissions, production, the application of...

Abstract The present microreview is aimed at describing the evolution of methodology used in aryl coupling reactions towards catalytically efficient and highly selective procedures, which have been achieved through use assisted metallacycle‐directed reactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

Abstract Selectively substituted phenanthridine derivatives are obtained by a facile reaction of o ‐alkylated aryl iodides, ‐bromoarenesulfonylanilines and activated olefins in the presence palladium norbornene as catalysts. The takes place under mild conditions to give products satisfactory yields using readily available starting materials.

An efficient partnership: A new synthesis of heteroatom-containing o-teraryls from aryl iodides and heteroarenes is based on the palladium/norbornene dual catalytic system involves sp2 CH activation both in arylation step leading to biaryl subsequent one involving heterocycle (see scheme). The combines ubiquitous structure with heterocyclic rings a one-pot reaction under mild conditions. Detailed facts importance specialist readers are published as "Supporting Information". Such documents...