A5019776623- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Catalytic Cross-Coupling Reactions
- Cyclopropane Reaction Mechanisms
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Radical Photochemical Reactions
- Synthesis and Catalytic Reactions
- Crystallization and Solubility Studies
- Sulfur-Based Synthesis Techniques
- Asymmetric Synthesis and Catalysis
- Catalytic Alkyne Reactions
- Organometallic Complex Synthesis and Catalysis
- CO2 Reduction Techniques and Catalysts
- Organoboron and organosilicon chemistry
- Enzyme Catalysis and Immobilization
- Innovative Microfluidic and Catalytic Techniques Innovation
- Carbon dioxide utilization in catalysis
- Click Chemistry and Applications
- Neuropeptides and Animal Physiology
- Coordination Chemistry and Organometallics
- Fluorine in Organic Chemistry
- Receptor Mechanisms and Signaling
- Organophosphorus compounds synthesis
AstraZeneca (Sweden)
2016-2025
AstraZeneca (Brazil)
2016-2025
Stockholm University
2016-2023
AstraZeneca (Netherlands)
2022
Medicina
2021
AstraZeneca (Canada)
2017-2019
Institute of Medicinal Plant Development
2019
Metabolism and Renal Physiology
2019
Faculdade Meridional
2016
Laerdal (Norway)
2016
A triphenylphosphinegold(I)-catalyzed cyclopropanation of olefins using propargyl esters as gold(I)−carbene precursors is reported. This reaction provided the basis for use a DTBM-SEGPHOS gold(I) complex catalyst in enantioselective (up to 94% ee) preparation vinyl cyclopropanes with high cis-selectivity.
In contemporary drug discovery, enhancing the sp
Abstract A diverse set of more than 40 highly functionalized biaryls was synthesized successfully through the Suzuki–Miyaura cross‐coupling reaction catalyzed by Pd nanoparticles supported in a mesoporous MOF (8 wt % Pd@MIL‐101(Cr)‐NH 2 ). This could be achieved under some mildest conditions reported to date and strong control over leaching metallic species maintained, despite presence functional groups and/or several heteroatoms. Some targeted molecules are important intermediates synthesis...
At the early stages of drug development process, thousands compounds are synthesized in order to attain best possible potency and pharmacokinetic properties. Once successful scaffolds identified, large libraries analogues made, which is a challenging time-consuming task. Recently, late stage functionalization (LSF) has become increasingly prominent since these reactions selectively functionalize C–H bonds, allowing quickly produce analogues. Classical electrophilic aromatic halogenations...
Asymmetric cyclopropane synthesis currently requires bespoke strategies, methods, substrates, and reagents, even when targeting similar compounds. This approach slows down discovery limits available chemical space. Introduced herein is a practical versatile diazocompound its performance in the first unified asymmetric of functionalized cyclopropanes. The redox-active leaving group this reagent enhances reactivity selectivity geminal carbene transfer. effect allowed cyclopropanation various...
Abstract In the last decade, visible‐light photoredox catalysis has evolved into a versatile tool in organic synthesis. However, most reports have used homemade photoreactors their design and optimisation of new methods, complicating reproducibility some transformations. To improve efficiency, laboratory been developed commercialized. Herein we report comparison four commercially available six mechanistically distinct reactions focusing on difference product yields kinetics as well factors...
The borylation of aryl and heteroaryl C–H bonds is valuable for the site-selective functionalization in complex molecules. Iridium catalysts ligated by bipyridine ligands catalyze bond that most acidic least sterically hindered an arene, but predicting site molecules containing multiple arenes difficult. To address this challenge, we report a hybrid computational model predicts Site Borylation (SoBo) SoBo combines density functional theory, semiempirical quantum mechanics, cheminformatics,...
Catalysed C-H activation has emerged as a transformative platform for molecular synthesis and provides new opportunities in drug discovery by late-stage functionalisation (LSF) of complex molecules. Notably, small aliphatic motifs have gained significant interest medicinal chemistry their beneficial properties applications sp
Abstract A directed heterogeneous C−H activation/halogenation reaction catalyzed by readily synthesized Pd@MOF nanocatalysts was developed. The Pd catalysts used were a novel and environmentally benign Fe‐based metal–organic framework (MOF) (Pd@MIL‐88B‐NH 2 (Fe)) the previously developed Pd@MIL‐101‐NH (Cr). Very high conversions selectivities achieved under very mild conditions in short times. wide variety of directing groups, halogen sources, substitution patterns well tolerated, valuable...
Electrooxidation has emerged as an increasingly viable platform in molecular syntheses that can avoid stoichiometric chemical redox agents. Despite major progress electrochemical C-H activations, these arene functionalizations generally require directing groups to enable the activation. The installation and removal of call for additional synthesis steps, which jeopardizes inherent efficacy activation approach, leading undesired waste with reduced step atom economy. In sharp contrast, herein...
A protocol for the C–H activation/iodination of benzoic acids catalyzed by a simple iridium complex has been developed. The method described in this paper allows ortho-selective iodination variety under extraordinarily mild conditions absence any additive or base 1,1,1,3,3,3-hexafluoroisopropanol as solvent. catalyst used tolerates air and moisture, selectively gives ortho-iodobenzoic with high conversions. Mechanistic investigations revealed that an Ir(III)/Ir(V) catalytic cycle operates,...
Efficient functionalization of C-H bonds can be achieved using transition metal catalysts, such as Pd(OAc)2. To better control the regioselectivity in these reactions, some functional groups on substrate may used directing groups, guiding reactivity to an ortho position. Herein, we describe a methodology score relative strength palladium-catalyzed aromatic activation. The results have been collected into scale that serves predict molecules with multiple competing groups. We demonstrate this...
Herein, we report an iridium-catalyzed directed C–H amination methodology developed using a high-throughput experimentation (HTE)-based strategy, applicable for the needs of automated modern drug discovery. The informer library approach investigating accessible directing group chemical space, in combination with functional tolerance screening and substrate scope investigations, allowed generation reaction application guidelines to aid future users. Applicability late-stage functionalization...
A library of novel and diverse P-chirogenic phosphine ligands containing a triazole moiety (ChiraClick ligands) were prepared in high yield modular fashion that allows for variation both the structure, as well giving access to two enantiomers ligand.
Introducing C 1 aliphatic motifs, including methyl, mono-, di-, and trifluoromethyl groups, to arenes at meta -position can be achieved by a ruthenium-catalyzed C–H functionalization decarboxylative sequence.
Late-stage functionalization (LSF) has over the past years emerged as a powerful approach in drug discovery process. At its best, it allows for rapid access to new analogues from single drug-like molecule, bypassing need
Abstract Secondary amines are vital functional groups in pharmaceuticals, agrochemicals, and natural products, necessitating efficient synthetic methods. Traditional approaches, including N -monoalkylation reductive amination, suffer from limitations such as poor chemoselectivity complexity. Herein, we present a streamlined deoxygenative photochemical alkylation of secondary amides, enabling the synthesis α-branched amines. Our method leverages triflic anhydride-mediated semi-reduction...
Direct cross-coupling reactions between two similar unactivated partners are challenging but constitute a powerful strategy for the creation of new carbon–carbon bonds in organic synthesis. [4]Dendralenes class acyclic branched conjugated oligoenes with great synthetic potential rapid generation structural complexity, yet chemistry [4]dendralenes remains an unexplored field due to their limited accessibility. Herein, we report highly selective palladium-catalyzed oxidative allenes presence...