A5030717162- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Oxidative Organic Chemistry Reactions
- Organoboron and organosilicon chemistry
- Various Chemistry Research Topics
- Inorganic and Organometallic Chemistry
- Chemical Synthesis and Reactions
University of Pavia
2022-2025
University of Amsterdam
2024
In contemporary drug discovery, enhancing the sp
The present review aims to provide an overview of the recent developments in preparation aryl‐ or alkenyl stannanes via carbon‐ and tin‐centered radicals enabling chemists synthesize organostannyl derivatives with high efficiency under mild conditions.
There is an urgent need to develop uncharged radical precursors be activated under mild photocatalyzed conditions. 2-Substituted-1,3-oxazolidines (Eox < 1.3 V vs SCE, smoothly prepared from the corresponding aldehydes) have been herein employed for successful release of tertiary, α-oxy, and α-amido radicals photo-organo redox catalysis. The reaction relies on unprecedented C–C cleavage occurring cation these heterocyclic derivatives. Such a protocol applied visible-light-driven conjugate...
We describe herein easily oxidizable 2-substituted-1,3-imidazolidines for the photocatalyzed generation of (substituted) alkyl radicals forging C(sp 3 )–C(sp ) bonds under metal-free conditions.
In contemporary drug discovery, enhancing the sp3-hybridized character of molecular structures is paramount, necessitating innovative synthetic methods. Herein, we introduce a deoxygenative cross-electrophile coupling technique that pairs easily accessible carboxylic acid-derived redox-active esters (RAEs) with aldehyde sulfonyl hydrazones, employing Eosin Y as an organophotocatalyst under visible light irradiation. This approach serves versatile, metal-free C(sp3)−C(sp3) cross-coupling...
The increased demand for the synthesis of enriched hybridized Csp3 motifs and urgency discovering new drug molecules require development more efficient technologies synthetic tools to accelerate discovery processes. Herein, we report a fully automated strategy addition building blocks onto olefins via Giese forge Csp3-Csp3 bonds. developed protocol allowed conversion aldehydes (non-redox-active species) in-situ electroactive imidazolidines employ them as precursors C-centered radicals under...
Abstract In this work, silyl ethers of phenols and alcohols have been successfully prepared tested as neutral carbon (silicon) centered radical precursors. The organophotocatalyzed oxidation (by the Fukuzumi catalyst) these caused cleavage a C−Si (or Si−Si) bond for release desired to be used forging C( sp 3 ) −C( −Si) bonds via Giese reaction.
Abstract The increased demand for the synthesis of Csp 3 enriched motifs and urgency discovering new drugs requires development more efficient technologies synthetic tools to accelerate drug discovery processes. Herein, we report a fully automated strategy addition building blocks onto olefins via Giese forge −Csp bonds. developed protocol allowed in‐situ conversion aldehydes (non‐redox‐active species) electroactive imidazolidines their use as precursors C‐centered radicals under photoredox...