A5035714823- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Molecular spectroscopy and chirality
- Asymmetric Synthesis and Catalysis
- Axial and Atropisomeric Chirality Synthesis
- Chemical Synthesis and Reactions
- Cancer-related gene regulation
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Catalytic Reactions
- Mesoporous Materials and Catalysis
- HER2/EGFR in Cancer Research
- Chemical synthesis and alkaloids
- Oxidative Organic Chemistry Reactions
- Wnt/β-catenin signaling in development and cancer
- Crystallization and Solubility Studies
- Mast cells and histamine
- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Carbon dioxide utilization in catalysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- X-ray Diffraction in Crystallography
- Synthesis and Reactions of Organic Compounds
- Alkaloids: synthesis and pharmacology
University of Amsterdam
2022-2024
Sapienza University of Rome
2022-2024
Istituto Pasteur
2023
In contemporary drug discovery, enhancing the sp
The first catalytic enantioselective and diastereoselective synthesis of atropisomeric hydrazides was achieved using a sequential catalysis protocol. This strategy is based on one-pot sequence two organocatalytic cycles featuring the enamine amination branched aldehydes followed by nitrogen alkylation under phase-transfer conditions. resulting axially chiral were obtained directly from commercially available reagents in high yields with good stereocontrol. permutation organocatalysts allowed...
The ability to construct C(sp3 )-C(sp3 ) bonds from easily accessible reagents is a crucial, yet challenging endeavor for synthetic organic chemists. Herein, we report the realization of such cross-coupling reaction, which combines N-sulfonyl hydrazones and )-H donors through diarylketone-enabled photocatalytic hydrogen atom transfer subsequent fragmentation obtained alkylated hydrazide. This mild metal-free protocol was employed prepare wide array alkyl-alkyl cross-coupled products tolerant...
Thin films derived by the deposition of charged microdroplets generated in ESI source a mass spectrometer act as highly concentrated reaction vessels which final products an ion-molecule can be isolated their precipitation onto solid surface under ambient conditions. In this study, Z-spray supplied to Q-TOF Ultima was used investigate d-fructose acid-catalyzed reactions stainless-steel target surface. High conversion ratios into 5-hydroxymethylfuraldehyde (5-HMF), 5-methoxymethylfuraldehyde...
Despite intensive efforts, no inhibitors of the Wnt/β-catenin signaling pathway have been approved so far for clinical treatment cancer. We synthesized novel N-(heterocyclylphenyl)benzenesulfonamides as β-catenin inhibitors. Compounds 5–10 showed strong inhibition luciferase activity. 5 and 6 inhibited MDA-MB-231, HCC1806, HCC1937 TNBC cells. Compound 9 induced in vitro cell death SW480 HCT116 cells vivo tumorigenicity a human colorectal cancer line HCT116. In co-immunoprecipitation study...
Abstract The first catalytic enantioselective and diastereoselective synthesis of atropisomeric hydrazides was achieved using a sequential catalysis protocol. This strategy is based on one‐pot sequence two organocatalytic cycles featuring the enamine amination branched aldehydes followed by nitrogen alkylation under phase‐transfer conditions. resulting axially chiral were obtained directly from commercially available reagents in high yields with good stereocontrol. permutation...
Abstract Catalytic enantioselective Strecker reactions on an achiral substrate using sub-stoichiometric amounts of a chiral catalyst represent evolving key strategy for the effective synthesis α-amino nitriles. We herein disclosed set-up flow-based methodology Strecker, employing ethyl cyanoformate as relatively safe cyanide source, cinchona-based catalyst, and methanol additive. A thorough exploration parameters allowed identification most efficient reagent mixing mode, optimum solvent flow...
In contemporary drug discovery, enhancing the sp3-hybridized character of molecular structures is paramount, necessitating innovative synthetic methods. Herein, we introduce a deoxygenative cross-electrophile coupling technique that pairs easily accessible carboxylic acid-derived redox-active esters (RAEs) with aldehyde sulfonyl hydrazones, employing Eosin Y as an organophotocatalyst under visible light irradiation. This approach serves versatile, metal-free C(sp3)−C(sp3) cross-coupling...
Abstract A novel C3‐symmetric multi–amino catalyst was synthesized and evaluated in the asymmetric Michael addition to produce warfarin its analogues. The turned out be efficient up 1 % molar without use of acidic additives providing desired product 82 yield maintaining good level enantioselectivity. ESI‐MS experiments together with data supplied by theoretical models allowed us understand operating mechanism catalyst, clarifying role amine functions confirming catalyst's multifunctionality....
1,2-Diphenylethylenediamine (DPEDA) is a privileged chiral scaffold being used in the construction of broad variety organocatalysts and ligands for enantioselective organic reactions. This molecule gave significant contribution synthesis structurally different bi/multifunctional organocatalysts. DPEDA played an essential role development capable yielding important information on reaction mechanisms, like enamine, iminium, hydrogen-bonding anion-binding catalysis. The aim present review to...
Abstract The ability to construct C(sp 3 )−C(sp ) bonds from easily accessible reagents is a crucial, yet challenging endeavor for synthetic organic chemists. Herein, we report the realization of such cross‐coupling reaction, which combines N‐ sulfonyl hydrazones and )−H donors through diarylketone‐enabled photocatalytic hydrogen atom transfer subsequent fragmentation obtained alkylated hydrazide. This mild metal‐free protocol was employed prepare wide array alkyl‐alkyl cross‐coupled...
The dynamic scenario of di-aryls-pyrano-chromenes was investigated using DFT calculations. symmetry the chromene scaffold and presence two ortho-substituted aryls substituents can generate syn/anti diastereoisomers conformational enantiomers with different rotational barriers. relative conformations configurations were derived NOESY-1D experiments. Depending on energies related to exchange, experimental energy barriers determined through Dynamic NMR, HPLC or kinetic studies. atropisomeric...
The ability to construct C(sp3)–C(sp3) bonds from easily accessible reagents is a crucial, yet challenging endeavor for synthetic organic chemists. Herein, we report the realization of such cross-coupling reaction, which combines N-sulfonyl hydrazones and C(sp3)–H donors through diarylketone-enabled photocatalytic Hydrogen Atom Transfer subsequent fragmentation obtained alkylated hydrazide. This mild metal-free protocol was employed prepare wide array alkyl-alkyl cross-coupled products...