Background. Most traditional medicines were prepared from plant origins. These plants could be contaminated by heavy metals, pesticides, and/or toxins. Therefore, the aim of present study was to determine level metals such as lead (Pb), cadmium (Cd), chromium (Cr), and copper (Cu) in frequently used herbal preparations sold Northeast Ethiopia estimate their health risks associated with daily intake. Methods. A total 6 randomly collected local shops Dessie Kombolcha town, Ethiopia. The...

Low-field Magnetic Resonance Imaging (MRI) has the potential to provide autonomous accessible neuroimaging in remote communities, particularly Canadian north. Remoteness necessitates that these MRIs be built and maintained within communities. This approach not only ensures remain operational but will also allow youth from communities pursue technical careers at home. The first step this vision is establish resources needed for building are available an educational program give students...

Inappropriate self-medication is a public-health problem worldwide. Major problems associated with include wastage of resources, increased resistance pathogens, and adverse drug reactions.The aim this study was to assess practices factors among undergraduate Wollo University students in Northeast Ethiopia.A cross-sectional conducted 341 university using pretested self-administered questionnaire from January February 2019. Simple random sampling used select participants. Data were collected...

Background. Excess accumulation of potentially toxic elements in frequently consumed fruits is a serious threat to human health. The aim this study was determine the levels cadmium (Cd), chromium (Cr), copper (Cu), and lead (Pb) estimate noncarcinogenic carcinogenic health risks associated with their daily intake commonly Bahir Dar town, northwest Ethiopia. Methods. Three types (mango, banana, orange) were collected using simple random sampling method from open markets town. Wet digestion...

The aim of this study was to investigate the effects using questioning method on students’ critical thinking (CT) skills. To effect, a pretest-posttest two groups quasi-experimental design employed. Data obtained through tests and focus group discussion. Sixty management students participated in study. While treatment received method, comparison learned conventional method. quantitative data analyzed paired sample t-test while qualitative thematically. findings revealed that there...

Emergence of drug resistance and lack therapeutic efficacy modern antimalarial drugs are the most triggering factors for searching new lead compounds with different mechanisms action. Medicinal plants documented traditional uses a viable option treatment malaria. Traditionally, leaf latex Aloe weloensis has been used in malaria Ethiopia. Hence, this study was undertaken to investigate activity Plasmodium berghei-infected mice. A four-day suppressive test employed evaluate effect plant...

Background: Disposal of pharmaceutical waste among patients is a global challenge especially in developing countries like Ethiopia. Improper medication disposal can lead to health problems and environmental contaminations. Therefore, the present study aimed assess practices unused medications public centers Dessie town, Northeast Methods: A descriptive cross-sectional was conducted 263 four Ethiopia from March June, 2019. Face-to-face interviews using structured questionnaires were used...

The role of free radical reactions in disease pathology is well known to be involved many acute and chronic disorders human beings, such as diabetes, atherosclerosis, aging, immunosuppression neurodegeneration. search for new drugs plant origin becomes increasingly urgent due drug resistance. Aloe schelpei an endemic species traditionally used the treatment infectious diseases.This study was conducted evaluate scavenging activities leaf latex its isolated compounds.The A. subjected...

The use of ineffective and poor quality drugs endangers therapeutic treatment may lead to failure. For desired effect, should contain the appropriate amount active pharmaceutical ingredient required physical characteristics.The aim this study was evaluate as well physicochemical bioequivalence different brands furosemide tablets marketed in Bahir Dar, Northwest Ethiopia.Five were purchased from community pharmacies Dar city, Ethiopia. control parameters determined by identification, weight...

Background: Disposal of pharmaceutical waste among patients is a global challenge, especially in developing countries like Ethiopia. Improper medication disposal can lead to health problems and environmental contamination. Therefore, the present study was aimed assess practices unused medications public centers Dessie town, Northeast Methods: A descriptive cross-sectional survey conducted 263 four Ethiopia from March June 2019. Face-to-face interviews using structured questionnaires were...

Good quality drugs fulfilling the regulatory parameters and produced per current good manufacturing (CGMP) standards are very critical for best therapeutic outcome in patient therapy. Hence, this study assesses as well physicochemical bioequivalence of five brands glibenclamide tablets marketed Addis Ababa using vitro vivo methods. Friability, disintegration, dissolution, assay content active ingredients were evaluated methods described British Pharmacopeia (2009) United States (2007). All...

In this study, an attempt was made to assess quality as well pharmaceutical equivalence of six brands metformin hydrochloride tablets marketed in Addis Ababa using vitro methods. Friability, disintegration, dissolution and assay for the content active ingredients were evaluated methods described United States pharmacopeia (2007). All complied with official specification hardness, friability, disintegration assay. Five USP tolerance limits but Metformin Denk failed release stated amount....

Malaria is a major health concern in the world general and developing countries particular. Nowadays, control of malaria has ended up steadily more complex due to spread drug-resistant parasites. Medicinal plants are verifiable source compelling antimalarial drugs. The present study was aimed assess vivo activity leaf latex A. melanacantha against Plasmodium berghei mice.Acute oral toxicity assessed mice dose 2,000 mg/kg. A four-day suppressive model utilized investigate plant. Three extract...

Background: Antimicrobial drug therapy problems refer to incorrect and inappropriate utilization of antimicrobials which affect patient's health outcomes results in bacterial resistance. Incorrect use antimicrobial agents is a key driver for the spread Improving has an important effect on patients' health, treatment costs, enhancing quality life. Hence, aim present study was assess among patients Outpatient Department Ataye hospital, Northeast Ethiopia. Methods: A hospital-based...

Background This study aimed to comparatively evaluate the quality and physicochemical bioequivalence of commercially available brands hydrochlorothiazide (HCT) tablets in community pharmacies Dessie town, Northeast Ethiopia. Methods Experimental cross-sectional design was applied using pharmacopeia non-pharmacopeia methods. The difference (f1) similarity (f2) factors were calculated assess vitro generic products with comparator. Result results revealed that all investigated contained...

The introduction of generic drug products from multiple sources into the health care system many developing countries may lead to spread substandard medicines. Post marketing surveillance is very crucial ensure product quality and eliminate medicines consequently, better patient clinical outcome. Hence, aim present work was assess six ciprofloxacin hydrochloride 500 mg tablets available in Dessie town, Northeast Ethiopia using vitro control tests. Weight variation test, disintegration...

A two-channel, self-shielded, cylindrical, transverse gradient coil is numerically designed. The four quadrants of both the inner and outer cylinders were each divided into two sections. All symmetric sections primary corresponding shielding turns are assigned to first channel where enclosing belong second channel. Quasi-elliptic curves used for tracks design. Achieving a comparable target field, DC dissipated power two-channel lower compared conventional designed with similar dimensions...

Abstract Background This study aimed to evaluate the quality and physicochemical bioequivalence of commercially available brands hydrochlorothiazide 25mg tablets in community pharmacies Dessie town, Northeast Ethiopia. Methods Experimental-based cross-sectional design was applied using disintegration, identification, friability, uniformity, hardness, assay test methods as described USP. Difference (f1) similarity (f2) factor values were calculated assess vitro generic products with...

Eddy-currents are generated in MRI scanners’ metallic structures due to the rapid switching of gradient coils. They may result image distortions and induce acoustic-noise particularly for fast/spiral sequences. Transient eddy-currents computations can be used understand extent such effects. In this work, a numerical framework was devised compute transient induced by an amplitude-modulated sinusoidal pulse longitudinal coil configuration. Stream functions representation...

Eddy-currents induced by MRI gradient coils due to rapid switching result in undesirable thermal effects, field distortions and acoustic-noise. Efficient numerical computations are needed analyze eddy-currents for complex configurations. The skin-depth adds an extra computational burden eddy-current since meshing the direction may be achieve reliable during harmonic analysis. Here, we use a single-layer stream-function method (SSM) applying resistance compensation compare our results...