A5060185258- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Atomic and Subatomic Physics Research
- MRI in cancer diagnosis
- Cardiac Imaging and Diagnostics
- Medical Imaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Neonatal and fetal brain pathology
- Advanced NMR Techniques and Applications
- Domain Adaptation and Few-Shot Learning
- Functional Brain Connectivity Studies
- Bone and Joint Diseases
- Spinal Dysraphism and Malformations
- Traumatic Brain Injury Research
- NMR spectroscopy and applications
- Ultrasound Imaging and Elastography
- Pericarditis and Cardiac Tamponade
- Hemostasis and retained surgical items
- Electrical and Bioimpedance Tomography
- Intracranial Aneurysms: Treatment and Complications
- Spine and Intervertebral Disc Pathology
- Glioma Diagnosis and Treatment
- Autopsy Techniques and Outcomes
- Aortic Disease and Treatment Approaches
University of Toronto
2007-2024
Hospital for Sick Children
2008-2024
SickKids Foundation
2008-2023
Mental Health Research Canada
2023
Hennepin County Medical Center
2008
University of Minnesota Medical Center
2008
Stanford University
2005-2006
Resonance Research (United States)
2005
Low-field Magnetic Resonance Imaging (MRI) has the potential to provide autonomous accessible neuroimaging in remote communities, particularly Canadian north. Remoteness necessitates that these MRIs be built and maintained within communities. This approach not only ensures remain operational but will also allow youth from communities pursue technical careers at home. The first step this vision is establish resources needed for building are available an educational program give students...
To retrospectively describe the magnetic resonance (MR) imaging characteristics of normal breast tissue and cancer in setting lactation.The HIPAA-compliant study was exempt from institutional approval, informed consent not required. Unilateral MR 10 breasts performed seven lactating patients aged 27-42 years. For three whom both were imaged, each imaged on a separate day. Nonenhanced T1-weighted fat-saturated T2-weighted images contrast material-enhanced dynamic three-dimensional (3D) spiral...
To investigate the accuracy of T 2 liver iron quantification using different curve-fitting models under varying acquisition conditions, and to compare in iron-overloaded patients reliability rapid measurements against approved slower T(2) protocols.Simulations were conducted assess influence various factors on measurement: model, signal-to-noise ratio (SNR), echo time (TE) spacing. Fifty-four pediatric assessed a standard two variations acquisitions. In both simulations vivo data, three...
For persons with hemophilia, optimization of joint outcomes is an important unmet need. The aim this initiative was to determine use ultrasound in evaluating arthropathy and move toward consensus among hemophilia care providers regarding the preferred protocols for global adaptation.A survey treatment centers conducted that focused on understanding how why being used endeavored definitions both point-of-care musculoskeletal (POC-MSKUS) full diagnostic ultrasound, terminology describe...
A 3-echo linear combination myelin imaging method is presented. The echo times and weights are chosen such that the signal-to-noise ratio (SNR) of myelin-water maximized, signals from other white matter components sufficiently suppressed. Interfering tissue water cerebrospinal fluid (CSF) much stronger than due to their longer T2 abundance. By carefully optimizing a 50-fold suppression achieved along with 10-fold CSF suppression. For comparison 4, 5, 32 filters also designed using same...
It has been suggested that, in late gadolinium enhancement, the signal of right ventricular myocardium is nulled at a shorter inversion time than left. While we initially made same observation, believe that difference not real, but results from artifacts. We present 7 cases as well computer simulations to describe nature these artifacts and explain how they can create impression different times for left ventricle. At are ideal black rim be seen border with blood on inside fat outside. This...
Craniocervical arterial dissection is a frequent cause of childhood ischemic stroke requiring prompt diagnosis and treatment. However, there no universal guideline for diagnostic cerebrovascular imaging in children. We assessed the role time-of-flight magnetic resonance angiography diagnosing craniocervical dissection. included children (1 month to 18 years) with from January 1998 June 2007. Institutional protocol required (MRI)/ all cases conventional cerebral if showed any arteriopathy....
Introduction Little is known about the longitudinal trajectory of brain growth in children with opsoclonus-myoclonus ataxia syndrome. We performed a evaluation volumes pediatric syndrome patients compared age- and sex-matched healthy children. Patients Methods This case-control study included magnetic resonance imaging (MRI) scans from consecutive (2009-2020) control FreeSurfer analysis provided automatic volumetry brain. Paired t tests were on curvature trajectories, Bonferroni correction....
Recently designed dipolar Halbach magnets used in portable MRI systems are much lighter and more compact than standard permanent or superconductive magnets. However, improved designs manufacturing techniques aiming at lower weight smaller external size an area of continual interest especially for application to space flight. Most magnet design aim optimize homogeneity suitable over a diameter-spherical volume (DSV) that requires the aspect ratio (length/inner diameter) be larger 1.5:1....
A rapid technique for mapping of T(2) relaxation times is presented. The method based on the conventional single-echo spin echo approach but uses a much shorter pulse repetition time to accelerate data acquisition. premise new use constant difference between and time, which removes restrictive requirement >> T(1). Theoretical simulation investigations were performed evaluate criteria accurate measurements. Measured T(2)s shown be within 1% error as long key criterion time/T(2) > or =3 met....
Tensor estimation can be improved by increasing the number of gradient directions (NGD) or signal averages (NSA), but at a cost increased scan time.To evaluate effects NGD and NSA on fractional anisotropy (FA) fiber density index (FDI) in vivo.Ten healthy adults were scanned 1.5T system using nine different diffusion tensor sequences. Combinations 7 NGD, 15 25 with 1 NSA, 2 3 used, times varying from to 18 min. Regions interest (ROIs) placed internal capsules, middle cerebellar peduncles,...
Abstract Recently a novel T 2 selective imaging method based on linear combination (LC) filtering was developed. By linearly combining images acquired with different echo times LC is able to generate showing only tissues preselected range of relaxation times. In this study the use in knee investigated. Three filters were designed: short filter for meniscus, medium articular cartilage, and long synovial fluid. To verify designs, eight phantoms imaged. addition, vivo from four asymptomatic...
Regional pulmonary blood flow can be assessed using both dynamic contrast-enhanced (DCE) MR and phase-contrast (PC) MR. These methods provide somewhat complementary information: DCE assess over the entire lung while PC detect rapid changes in to a targeted region. Although are considered accurate, one may more feasible than other depending on pathology, patient condition, availability of an intravenous route. The objective this study was establish consensus between two by comparing paired...
Summary Ultrasmall paramagnetic iron oxide ( USPIO )‐enhanced MRI is promising for evaluating inflammation. The aims of this study were to investigate the effect on cartilage T1 and T2 mapping, evaluate a proposed rapid vs. conventional map method imaging in blood‐induced arthritis model. Knees nine arthritic (induction by intra‐articular autologous blood injection) six control rabbits imaged over time (baseline, weeks 1, 5, 10) 1.5T . All had (35–75 μmol Fe/kg)‐enhanced at each point....
Signal analysis of FLAIR sequences is gaining momentum for studying neurodevelopment and brain maturation, but intensity varies across scanners needs to be normalized. This study aimed establish normative values standardized in the pediatric brain.