A5072411600- Pain Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Anesthesia and Pain Management
- Pain Management and Opioid Use
- Forensic Toxicology and Drug Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Health, Medicine and Society
- Nausea and vomiting management
- Pediatric Pain Management Techniques
- Airway Management and Intubation Techniques
- Opioid Use Disorder Treatment
- Musculoskeletal pain and rehabilitation
- Epilepsy research and treatment
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Healthcare Systems and Practices
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pharmaceutical Practices and Patient Outcomes
- Pain Management and Placebo Effect
- Pharmacological Receptor Mechanisms and Effects
- Spine and Intervertebral Disc Pathology
- French Urban and Social Studies
- Anesthesia and Neurotoxicity Research
Centre Hospitalier de l’Université de Montréal
2006-2024
Université de Montréal
2015-2024
The University of Texas MD Anderson Cancer Center
2018
McMaster University
2018
Hôtel-Dieu de Montréal
2001-2016
Hôpital Saint-Louis
1993-2014
Université Paris Cité
2014
Centre Hospitalier Universitaire de Limoges
2014
Université de Limoges
2011-2013
Hôpital Maisonneuve-Rosemont
2012
<h3>Background and Objectives</h3> General anesthesia for breast surgery may be supplemented by using a regional anesthetic technique. We evaluated the efficacy of first pectoral nerve block (Pecs I) in treating postoperative pain after cancer surgery. <h3>Methods</h3> A randomized, double-blind, dual-centered, placebo-controlled trial was performed. One hundred twenty-eight patients scheduled unilateral were recruited. multimodal analgesic regimen surgeon-administered local infiltration...
Abstract Background Data on postoperative outcomes of the COVID-19 patient population is limited. We described patients who underwent a surgery and pandemic impact surgical activities. Methods conducted multicenter cohort study between March 13 June 192,020. included all in nine centres Province Québec, Canadian province most afflicted by pandemic. also concomitant suspected (subsequently confirmed not to have COVID-19) had recovered from it. collected data baseline characteristics,...
Anandamide, an endocannabinoid, is degraded by the enzyme fatty acid amide hydrolase which can be inhibited nonsteroidal anti-inflammatory drugs (NSAIDs). The present work was designed to study peripheral interactions between anandamide and ibuprofen (a non-specific cyclooxygenase inhibitor) in rat formalin test. We first determined ED50 for (0.018 microg +/- 0.009), (0.18 0.09), their combination (0.006 0.002). Drugs were given 15 min before a 2.5% injection into dorsal surface of right...
2-arachidonoyl glycerol (2-AG) is an endogenous cannabinoid with central antinociceptive properties. Its degradation catalysed by monoacylglycerol lipase (MGL) whose activity inhibited URB602, a new synthetic compound. The peripheral effects of 2-AG and URB602 in inflammatory model pain are not yet determined. We have evaluated these without the CB(1) (AM251) CB(2) (AM630) receptor antagonists.Inflammation was induced rat hind paws intraplantar injection formalin. Nociception assessed...
There are limited options for the treatment of neuropathic pain. Endocannabinoids, such as anandamide and 2-arachidonoyl glycerol (2-AG), promising pain modulators there is recent evidence interactions between 2-AG biosynthesis metabolism. It has been clearly demonstrated that degradation mainly catalysed not only by monoacylglycerol lipase (MGL) but also a fatty acid amide hydrolase (FAAH). Inhibitors specifically targeting these two enzymes have described: URB602 URB597, respectively....
Abstract Neuropathic pain is one of the most inextricable problems encountered in clinics, because few facts are known about its etiology. Nerve injury often leads to allodynia and hyperalgesia, which symptoms neuropathic pain. The aim this study was understand some molecular electrophysiological mechanisms after chronic constriction saphenous nerve (CCS) mice. After surgery, CCS mice displayed significant were sensitive acute systemic injection morphine (4 mg/kg), gabapentin (50...
This study was designed to estimate the validity of an 11-point verbal numerical rating scale (VNRS) and a 100 Unit (U) plasticized visual analogue (VASp) using 100mm paper (VAS) as gold standard, recommend best method reporting intensity acute pain in emergency department (ED). A convenience sample 1176 patients with were recruited ED teaching hospital. Patients >18 years able use different scales included. Scales presented randomly. Results converted 0-100 U quantified Bland-Altman...
The interactions between the cannabinoid and opioid systems for pain modulation are reciprocal. However, role importance of system in antinociceptive effects opioids remain uncertain. We studied these with goal highlighting involvement morphine-induced analgesia. In both phases formalin test, intra paw intrathecal morphine produced similar C57BL/6, type 1 2 receptor wild-type (respectively cnr1WT cnr2WT) mice. cnr1 cnr2 knockout (KO) mice, at dose used effect inflammatory phase test was...