A5115603405- Skin and Cellular Biology Research
- Contact Dermatitis and Allergies
- Cancer-related Molecular Pathways
- Dermatology and Skin Diseases
- Plant Reproductive Biology
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Hedgehog Signaling Pathway Studies
- T-cell and B-cell Immunology
- Wnt/β-catenin signaling in development and cancer
- Ion channel regulation and function
- Ubiquitin and proteasome pathways
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
University of Maryland, Baltimore
2013-2017
AP1 (jun/fos) transcription factors (c-jun, junB, junD, c-fos, FosB, Fra-1, and Fra-2) are key regulators of epidermal keratinocyte survival differentiation important drivers cancer development. Understanding the role these in epidermis is complicated by fact that each protein expressed, at different levels, multiple cells layers differentiating epidermis, because regulate competing processes (i.e., proliferation, apoptosis, differentiation). Various vivo genetic approaches have been used to...
Extracellular glutamate is elevated following brain ischemia or trauma and contributes to neuronal injury. We tested the hypothesis that magnesium sulfate (MgSO4, 3 mM) protects against metabolic failure caused by excitotoxic exposure. Rat cortical neuron preparations treated in medium already containing a physiological concentration of Mg2+ (1 could be segregated based on their response (100 µM). Type I responded with decrease small transient increase oxygen consumption rate (OCR). II...
AP1 transcription factors are important controllers of epidermal differentiation. Multiple family members expressed in the epidermis a differentiation-dependent manner, where they function to regulate gene expression. To study role factor signaling, TAM67 (dominant-negative c-jun) was inducibly suprabasal epidermis. The TAM67-positive displays keratinocyte hyperproliferation, hyperkeratosis and parakeratosis, delayed differentiation, extensive subdermal vasodilation, nuclear loricrin...