A5008842165- Voice and Speech Disorders
- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Head and Neck Cancer Studies
- Phonetics and Phonology Research
- Speech Recognition and Synthesis
- Health, Education, and Physical Culture
- Muscle Physiology and Disorders
- Speech and Audio Processing
- Thyroid and Parathyroid Surgery
- Advanced Neuroimaging Techniques and Applications
University of Pittsburgh
2019-2024
Google (United States)
2021
We have developed a novel surgical/computational model for the investigation of unilateral vocal fold paralysis (UVFP) which will be used to inform future in silico approaches improve surgical outcomes type I thyroplasty. Healthy phonation (HP) was achieved using cricothyroid suture approximation on both sides larynx generate symmetrical closure. Following high-speed videoendoscopy (HSV) capture, sutures right side were removed, partially releasing tension unilaterally and generating...
To investigate the feasibility of dynamic computed tomography in recording and describing spatial motion characteristics arytenoid cartilage.Dynamic recorded real-time trajectory cartilage during inspiration phonation. A stationary coordinate system was established with cricoid as a reference using movement cartilage. The Euler angles were calculated by transformation two systems, quantitatively studied.Displacement primarily inferior inspiration. During phonation, displacement mainly...
A full three-dimensional (3D) fluid-structure interaction (FSI) study of subject-specific vocal fold vibration is carried out based on the previously reconstructed models rabbit larynges. Our primary focuses are characteristics fold, unsteady 3D flow field, and comparison with a recently developed 1D glottal model that incorporates machine learning. The FSI applies strong coupling between finite-element for tissue incompressible Navier-Stokes equation flow. Five different samples larynx,...
Subject-specific computational modeling of vocal fold (VF) vibration was integrated with an ex vivo animal experiment type 1 thyroplasty to study the effect implant on vibration. In experiment, a rabbit larynx used simulate thyroplasty, where one side medialized trans-muscular suture while other silastic implant. Vocal then achieved by flowing air through and filmed high-speed camera. The three-dimensional model built upon pre-operative scan laryngeal anatomy. This subject-specific...
To investigate the value of diffusion tensor imaging (DTI) in evaluation vocal fold tissue microstructure after recurrent laryngeal nerve (RLN) injury.Six canines were divided into 2 groups: a unilateral paralysis group (n = 4) and control 2). The RLN was cut group, no intervention applied group. After 4 months, canines' larynges removed placed small animal magnetic resonance (MRI) system (9.4T BioSpec MRI; Bruker, Germany). scanning, folds isolated, sectioned, stained. slides then analyzed...
Glucocorticoids (GC)s are commonly employed to treat vocal fold (VF) pathologies. However, VF atrophy has been associated with intracordal GC injections. Dexamethasone-induced skeletal muscle is well-documented in other tissues and believed be mediated by increased proteolysis via upregulation of Muscle Ring Finger (MuRF)-1 Atrogin-1. Mechanisms dexamethasone-mediated have not described. This pilot study vitro vivo models investigate the effects dexamethasone on epithelium, thyroarytenoid...
This study aimed to produce customized silicone elastomer implants of varied size and shape for optimization type I thyroplasty procedures in a rabbit model. Computer-aided design models different implant designs were designed used program laser cutting medical-grade Silastic® sheet. Laser-cut produced rapidly cost-efficiently. Surgical implantation demonstrated vocal fold medialization phonation 5 test subjects. technique may provide low-cost alternative or adjunct method hand-carving...
Objectives/Hypothesis: Systemic glucocorticoids (GC)s are employed to treat various voice disorders. However, GCs have varying pharmacodynamic properties with adverse effects ranging from changes in epithelial integrity, skeletal muscle catabolism, and altered body weight. We sought characterize the acute temporal of systemic dexamethasone methylprednisolone on vocal fold (VF) glucocorticoid receptor (GR) nuclear translocation, tight junction (ZO-1) expression, thyroarytenoid (TA) fiber...