A5088821431- Fungal and yeast genetics research
- Microtubule and mitosis dynamics
- Biofuel production and bioconversion
- Genomics and Chromatin Dynamics
- Photosynthetic Processes and Mechanisms
- 14-3-3 protein interactions
- Ubiquitin and proteasome pathways
- Plant-Microbe Interactions and Immunity
University of Manchester
2013-2017
Cancer Research UK Manchester Institute
2017
Universidad de Salamanca
2005-2015
Instituto de Biología Funcional y Genómica
2015
Schizosaccharomyces pombe cells divide by medial fission through contraction of an actomyosin ring and deposition a multilayered division septum that must be cleaved to release the two daughter cells. Here we describe identification seven genes (adg1(+), adg2(+), adg3(+), cfh4(+), agn1(+), eng1(+), mid2(+)) whose expression is induced transcription factor Ace2p. The all these varied during cell cycle, maximum being observed septation. At least three proteins (Eng1p, Agn1p, Cfh4p) localize...
The fission yeast scaffold molecule Sid4 anchors the septum initiation network to spindle pole body (SPB, centrosome equivalent) control mitotic exit events. A second SPB-associated scaffold, Cut12, promotes Cdk1–cyclin B drive commitment. Signals emanating from each have been assumed operate independently promote two distinct outcomes. We now find that signals contribute Cut12 commitment switch. Specifically, phosphorylation of by NIMAFin1 reduces affinity for its SPB anchor, Ppc89, while...
The division cycle of unicellular yeasts is completed with the activation a cell separation program that results in dissolution septum assembled during cytokinesis between 2 daughter cells, allowing them to become independent entities. Expression eng1+ and agn1+ genes, encoding hydrolytic enzymes responsible for degradation, activated at end each by transcription factor Ace2. Periodic ace2+ expression regulated transcriptional complex PBF (PCB Binding Factor), composed forkhead-like proteins...