Our objectives were to evaluate the effect of rosiglitazone on bone metabolism and assess association between changes in turnover parameters plasma cytokine levels postmenopausal diabetic women.This was a 12-wk open-label randomized-controlled trial.A total 56 obese women with newly diagnosed diabetes 26 nondiabetic healthy controls matched for age body mass index included study.The subjects instructed follow weight-maintenance diet. Half randomly assigned receive 4 mg/d, other half remained...

BACKGROUNDThis prospective randomized-controlled animal study was designed to determine the effects of atorvastatin on experimentally induced endometriosis in a rat model.

A decline in kidney function after contrast exposure is associated with a high risk of morbidity and mortality during hospitalization over long-term periods. Several retrospective recent prospective clinical trials have shown that statin therapy might prevent contrast-induced nephropathy patients undergoing percutaneous coronary intervention. In this study, we aimed to assess the effects therapies on renal parameters elective angiography. One hundred sixty angiography were randomized equally...

This study investigated changing levels of serum oxidant/antioxidant with chemotherapy and their relation to treatment in 34 Hodgkin's lymphoma patients. The patient population consisted 19 males 15 females. Mean age was 30.41 +/- 12.08 years. All patients received the adriamycin, bleomycin, vincristine dexamethasone (ABVD) protocol. Blood samples were taken before treatment, on days 1 7 during for measurement superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT),...

To evaluate the presence of myocardial injury during convulsive seizures in children and adolescents by determining serum concentrations cardiac troponin I (cTnI), creatine kinase-MB mass (CK-MB mass), plasma brain-type natriuretic peptide (BNP).Thirty-one (20 boys; mean age, 6.6 +/- 5.34 years) with 50 healthy were enrolled. Serum cTnI, CK-MB mass, BNP analyzed 12 h after seizure repeated 7 days thereafter patient group obtained one time control group.The difference between cTnI was not...

To investigate levels of vascular endothelial growth factor (VEGF) and nitric oxide (NO) in the aqueous humor plasma patients with pseudoexfoliation syndrome (PXS) glaucoma (PXG), compared controls.This prospective study involved 37 PXS, 15 PXG, 32 control subjects whom cataract surgery was indicated. Aqueous VEGF NO were measured enzyme-linked immunosorbent assay chemiluminescence methods, respectively.Aqueous concentrations higher PXS PXG than controls (P<0.001). (P<0.05 P=0.001,...

To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and urinary TGF-β levels. Cross-sectional study conducted at the Department Endocrinology Baskent University School Medicine. Patients diabetes mellitus without known overt nephropathy were included study. Recruited stratified into four groups, matched terms age, gender, level estimated GFR calculated MDRD. 78 enrolled. They categorized groups depending on their...

Vaccination against SARS-CoV-2 may reduce COVID-19 mortality and complications in solidorgan transplant recipients, we evaluated the associated antibody responses adverse effects this high-risk population.This prospective observational study (April-June 2021) included 10 liver 38 kidney recipients who received 2 vaccine doses (Sinovac, n = 31; or BioNTech, 17) 56 healthy adults (Sinovac), all of whom provided 3 blood samples (prevaccination, 4 weeks after first dose, 4-6 second dose) for...

Surfactant Protein D (SP-D) is an important marker in chronic obstructive pulmonary disease (COPD). Serum SP-D levels increase while lung production of decreases COPD. a specific biomarker for monitoring COPD, assessment exacerbation frequency and arrangement treatment modalities. In the present study, we aimed to investigate correlation between serum induced sputum with severity acute exacerbations 20 healthy subjects, older than 40 years, at least 10 pack/years smoking history (group 1),...

Abstract Objectives The present study aimed to develop a clinical decision support tool assist coronavirus disease 2019 (COVID-19) diagnoses with machine learning (ML) models using routine laboratory test results. Methods We developed ML data (n = 1,391) composed of six chemistry (CC) results, 14 CBC parameter and results severe acute respiratory syndrome 2 real-time reverse transcription–polymerase chain reaction as gold standard method. Four algorithms, including random forest (RF),...

&lt;i&gt;Purpose:&lt;/i&gt; We aimed to investigate the effects of methylene blue (MB) on NO production, myeloperoxidase (MPO) activity, antioxidant status and lipid peroxidation in lung injury during different stages sepsis rats. &lt;i&gt;Material Methods:&lt;/i&gt; Rats were randomly divided into 4 groups (n = 20): group C, sham operated; CMB, operated receiving MB (25 mg/kg, i.p.); S, sepsis; SMB, i.p.). Sepsis was induced by cecal ligation puncture (CLP). The dose administered after CLP....

The aim of this study is to evaluate growth and insulin-like factor 1 (IGF-1) binding protein 3 (IGFBP-3) levels in infants with congenital heart disease (CHD) pre- postoperatively over a period year. Anthropometric values serum IGF-1 IGFBP-3 40 CHD (20 cyanotic 20 acyanotic) were compared 32 healthy controls. Acyanotic pulmonary hypertension (PH) presented significantly more failure. Preoperatively, lower the acyanotic group than control groups (p=0.22; p<0.01). upward trend year-long...

Elevated serum levels of neuron-specific enolase (NSE) was initially assumed to be specific neuronal tumors (particularly neuroblastoma), but is now known accompany nontumoral conditions and other than neuroblastomas. There a need establish normal ranges for NSE, especially in early infancy. The aims this study were determine reference values NSE newborns young infants assess whether infancy (i.e., preterm term infants) differ from the adult range enzyme.We enrolled 140 healthy babies, which...

To evaluate whether there is a correlation between insulin resistance and nitric oxide-related endothelial dysfunction in patients with polycystic ovarian syndrome (PCOS).The study was conducted 25 young women PCOS healthy women, 18 35 years of age. Plasma asymmetric dimethylarginine (ADMA) levels, serum oxide (NO) homeostatic model assessment (HOMA-IR) rates were measured both the patient control groups.Plasma ADMA levels significantly higher than controls (P = 0.001). Serum NO lower...

Abstract The possible difference of antimüllerian hormone (AMH) levels at central precocious puberty (CPP) and premature thelarche (PT) has not been properly evaluated. By evaluating AMH in girls with diagnosed CPP PT, we aim to show the change pubertal onset. Sixty-five who have breast development before age 8 years 25 healthy were enrolled study. subjects divided into two groups as according results GnRH test. determined groups. mean group significantly lower than those PT (13.57±9.85...

We investigated acupuncture, a potential contributor for burn care, on physiological and pathological pain mechanisms systemic local inflammatory responses in rat experimental model. Forty male Sprague-Dawley rats were divided into two groups. One-hour groups (five rats/group) observed 1 hour included Sh1 (sham/observation), ShA1 (sham + acupuncture/observation), Brn1 (burn/observation), BrnA1 (burn acupuncture/observation). Seven-day 7 days Sh7 ShA7 Brn7 BrnA7 "Pain-distress scores" noted...

Automated machine learning (AutoML) tools can help clinical laboratory professionals to develop models. The objective of this study was a novel formula for the estimation urine osmolality using an AutoML tool and determine efficiency in setting.Three hundred routine urinalysis samples were used reference chemistry analysis. H2O engine completed development steps with minimum human intervention. Four feature groups created, which include different measurements according Boruta selection...

Doxycycline (Dox) has a number of non-antibiotic properties. One them is the inhibition matrix metalloproteinase (MMP) activity. The aim this study was to assess effects Dox in rat endometriosis model. Endometriosis surgically induced 40 rats by transplanting endometrial tissue. After 3 weeks, repeat laparotomies were performed check implants and animals randomized into four groups: Group I, low-dose (5 mg/kg/day); II, high-dose (40 III, leuprolide acetate 1 mg/kg single dose, s.c.; VI...

Background The metabolic syndrome, syndrome X, is a group of disorders in which insulin resistance plays pivotal role. MS an important risk factor for subsequent development type 2 diabetes and cardiovascular disease. Fetuin‐A liver derived blood protein that acts as effective inhibitor soft tissue calcification. Cystatin C useful marker measuring glomerular filtration rate. Moreover, recently it has been suggested cystatin may be potential biomarker detecting microalbuminuria....

The current study sought to examine the interactions between inflammatory and immune events in lung circulating interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) levels at different burn depths with concomitant smoke inhalation rat model. Forty-eight female Sprague-Dawley rats were divided into six groups: S, sham; P, partial-thickness burns; F, full-thickness I, inhalation; Pi, burns + Fi, inhalation. Blood samples biopsies obtained 24 hours later. of IL-6, TNF-α,...