A5100776882- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Autophagy in Disease and Therapy
- Genomics, phytochemicals, and oxidative stress
- Pediatric Hepatobiliary Diseases and Treatments
- Natural product bioactivities and synthesis
- Barrier Structure and Function Studies
- Ginger and Zingiberaceae research
- NF-κB Signaling Pathways
- Drug-Induced Hepatotoxicity and Protection
- Contact Dermatitis and Allergies
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Curcumin's Biomedical Applications
- Alcohol Consumption and Health Effects
- Organ Transplantation Techniques and Outcomes
- Inflammasome and immune disorders
- Bone Metabolism and Diseases
- Gut microbiota and health
- Immune Response and Inflammation
- Pharmacy and Medical Practices
Wonkwang University
2010-2021
Chung-Ang University
2016
Kyungpook National University
2009
// Saroj Nepal 1 , Mi Jin Kim Tae Hong 2 Sang Hyun 3 Dong-Hwan Sohn 4 Sung Hee Lee Kyung Song Dong Young Choi Eung Seok and Pil-Hoon Park College of Pharmacy, Yeungnam University, Gyeongsangbuk-do, Republic Korea Pharmacy Medical Research Center, Chungbuk National Cheongju, Chungbuk, Department Pharmacology, School Medicine, Kyungpook Daegu, Institute Pharmaceutical Development, Wonkwang Iksan, Jeonbuk, Correspondence: Park, email: Keywords : apoptosis, autophagy, FoxO3A, leptin, p53...
We previously demonstrated that curcumin, a well-known antioxidant, inhibits collagen deposition in carbon tetrachloride-induced liver injury rats. The major effector cells responsibleforcollagensynthesis the are activated hepatic stellate cells. In this study,we investigated inhibitory effects of curcumin on synthesis and activation rat in-vitro, cell in-vivo. production smooth muscle alpha-actin proteins alpha1(I) mRNA were studied in-vivo in-vitro. effect DNA was also determined In-vivo,...
Butein is known to be the major component of bark Rhus verniciflua Stokes (Anacardiaceae). The aim this work was investigate effects butein on liver fibrosis induced by carbon tetrachloride (CCl4) in rats, and explore its antifibrogenic mechanism. (10 mg/kg/day or 25 mg/kg/day) showed a significant reduction hydroxyproline malondialdehyde levels rats. expression α1(I) collagen tissue inhibitor metalloproteinase-1 (TIMP-1) mRNAs clearly reduced dose-dependent manner rats given compared with...
Abstract: We have studied the inhibitory effect of aloe emodin on hepatic stellate cells activation and proliferation, as these play a key role in pathogenesis fibrosis. Rat were activated by contact with plastic dishes, resulting their transformation into myofibroblast‐like cells. Primary exposed to (1–10 μg/ml). Possible cytotoxic effects measured hepatocytes using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay. The production type I collagen smooth muscle cell...
// Geom Seog Seo 1 , Wen-Yi Jiang 2 Jin Hua Chi Hao Won-Chul Park Dong Hwan Sohn Pil-Hoon 3 Sung Hee Lee Digestive Disease Research Institute, Wonkwang University College of Medicine, Jeonbuk, Republic Korea Institute Pharmaceutical and Development, Pharmacy, University, Yeungnam Gyeongbuk, Correspondence to: Lee, e-mail: gsseo@wku.ac.kr Keywords: HO-1, colorectal carcinoma cell, antitumor immunity, ICAM-1, CXCL10 Received: March 03, 2015 Accepted: May 18, Published: 28, ABSTRACT Heme...
Abstract We have previously reported that tetrandrine reduced hepatic stellate cell activation and collagen accumulation in liver fibrosis induced by biliary obstruction. In the present study, we examined apoptosis‐inducing effect of on activated cells, as therapeutic goal is to eliminate cells apoptosis. used rat transformed Simian virus 40 (T‐HSC/Cl‐6) overcome limitations inherent studying primary cultures cells. Tetrandrine treatment at doses 25 50 µg/ml for 12 h apoptosis confirmed DNA...
This study describes a systematic and efficient point-of-care home hospice information system, which can effectively manage patient easily be incorporated into service using wired and/or wireless communications mobile computing technology. To help with the design of portable we analyzed services provided by visiting nurses opinions users, based on 2005 Guidelines for Cancer Patient Management Program Ministry Health Welfare Korea. We performed trial three experienced nurses. A nurse use PDA,...
Hepatic stellate cells play a key role in the pathogenesis of hepatic fibrosis. In this study, we investigate inhibitory effect butein on activation and proliferation rat primary cultured cells. Possible cytotoxic effects were measured hepatocytes using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The production collagen smooth muscle alpha-actin proteins examined at same concentration, by western blot. alpha1(I) collagen, tissue inhibitor metalloproteinase-1,...