Abstract Sepsis and septic shock are prevalent life-threatening complications in burn patients. Despite their severity, existing diagnostic methods limited. This study aims to evaluate the efficacy of Complete Blood Count (CBC) CBC ratio markers diagnosing sepsis shock, predicting mortality among A cohort 2757 patients was examined ascertain correlation between various parameters, ratios, incidence related mortality. Key analyzed included Red Cell Distribution Width (RDW), Mean Platelet...

Abstract This study aims to evaluate the utility of complete blood count (CBC) markers, in conjunction with acute kidney injury network (AKIN) criteria, for early detection, severity assessment, and prediction mortality outcomes (AKI) burn patients. The research seeks fill existing gaps knowledge validate cost-effectiveness using CBC as a routine diagnostic tool better management AKI. was conducted at Hangang Sacred Heart Hospital. We performed large-scale retrospective analysis 2758 adult...

Fibroblasts synthesize and secrete dermal collagen, matrix proteins, growth factors, cytokines. These characteristics of fibroblasts provide a potential way for fibroblast therapy to treat skin ulcers more effectively than conventional therapies such as cytokine negative pressure wound therapy. However, the obstacle commercialization is limited supply cells with consistent quality. In this study, we tested whether human embryonic stem cell-derived mesenchymal (hESC-MSCs) could be...

Purpose Sepsis-3 is a life-threatening organ dysfunction caused by dysregulated host responses to infection; and defined using the criteria, introduced in 2016, however, criteria need be validated specific clinical fields. We investigated mortality prediction compared diagnostic performance of quick Sequential Organ Failure Assessment (qSOFA), systemic inflammatory response syndrome (SIRS), burn-specific SIRS (bSIRS) burn patients. Methods This single-center retrospective cohort study...

Abstract Background Sepsis is a potentially life-threatening condition that occurs when the body’s response to infection leads widespread inflammation and tissue damage. Negative cultures can make it difficult for clinicians diagnosis may raise questions about validity of definition sepsis. In addition, clinical distinctions between burn patients with blood culture-positive -negative sepsis are also poorly understood. Therefore, this study aimed examine differences in order improve...

Burn injuries often result in a high level of clinical heterogeneity and poor prognosis patients with severe burns. Clustering algorithms, which are unsupervised methods that can identify groups similar trajectories heterogeneous diseases, provide insights into the mechanisms disease pathogenesis. This study aimed to analyze routinely collected biomarkers understand their mortality prediction power, meanings or subtypes, inform treatment decisions improve outcomes retrospective cohort...

Abstract Background Sepsis is a grave medical disorder characterized by systemic inflammatory response to infection. Furthermore, it leading cause of morbidity and mortality, especially in hospitalized patients. Acute kidney injury (AKI) common complication sepsis associated with increased mortality. Patients burns are particularly vulnerable developing AKI due the extensive tissue damage immune suppression resulting from burn injury. In this study, unsupervised clustering algorithms were...

Acute Respiratory Distress Syndrome (ARDS) is a critical form of Lung Injury (ALI), challenging clinical diagnosis and severity assessment. This study evaluates the potential utility various hematological markers in burn-mediated ARDS, including Neutrophil-to-Lymphocyte Ratio (NLR), Mean Platelet Volume (MPV), MPV-to-Lymphocyte (MPVLR), count, Distribution Width (PDW). Employing retrospective analysis data collected over 12 years, this focuses on relationship between these ARDS hospitalized...

Acute kidney injury (AKI) is a significant complication in burn patients, impacting outcomes substantially. This study explores the heterogeneity of AKI patients by analyzing creatinine time-series data to identify distinct clusters and evaluating routine biomarkers’ predictive values. A retrospective cohort analysis was performed on 2608 adult admitted Hangang Sacred Heart Hospital’s Burn Intensive Care Unit (BICU) from July 2010 December 2022. Patients were divided into four based...

Acute Respiratory Distress Syndrome (ARDS) is a severe complication in burn patients, characterized by rapid lung inflammation and hypoxemia. Managing ARDS challenging due to its high mortality rates the complex interplay of various pathophysiological factors. This study aims investigate heterogeneity patients admitted Intensive Care Unit (ICU) evaluate predictive efficacy biomarkers comparison PaO2/FiO2 (PF) ratio. A retrospective cohort was conducted at Burn Hangang Sacred Heart Hospital...

Burn injury has high clinical heterogeneity and worse prognosis in severely burned patients. Clustering algorithms using unsupervised methods to identify groups with similar trajectories heterogeneous disease patients can provide insight into mechanisms of pathogenesis. This study analyzed routinely collected biomarkers evaluate mortality prediction, find meanings for these or their subtypes, patterns.This retrospective cohort included aged >18 years, between July 2012 June 2021. All...

Background: Acute kidney injury (AKI) presents a complex challenge in burn patients, characterized by clinical heterogeneity and significant morbidity mortality. Understanding the variability AKI, especially among victims, is crucial for effective patient management outcome prediction.Methods: This study examined 1545 patients diagnosed with AKI at Burn Intensive Care Unit of Hangang Sacred Heart Hospital, Hallym University Medical Center, from January 2010 to December 2022. was based on...

Background: Acute Respiratory Distress Syndrome (ARDS) presents a significant challenge in burn patients, characterized by high mortality rates and clinical heterogeneity. This study aimed to explore the complexity diversity of ARDS patients identify subgroups with distinct characteristics responses treatment. Understanding these variations is crucial for improving patient outcomes through tailored treatments.Methods: Conducted at Hangang Sacred Heart Hospital, this retrospective cohort...