A5078407743- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Viral Infectious Diseases and Gene Expression in Insects
- Virology and Viral Diseases
- RNA regulation and disease
- Autophagy in Disease and Therapy
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Plant and Fungal Interactions Research
- Vector-borne infectious diseases
- HIV Research and Treatment
- Transgenic Plants and Applications
- Vector-Borne Animal Diseases
- Rabies epidemiology and control
South China Agricultural University
2021-2024
Huazhong Agricultural University
2023-2024
Shanghai Zhangjiang Laboratory
2024
Key Laboratory of Guangdong Province
2021-2022
Ministry of Agriculture and Rural Affairs
2022
Porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis (TGEV) are major intestinal coronaviruses that cause vomiting, diarrhea, dehydration, mortality in piglets. These viruses coexist lead to significant economic losses the swine industry. Virus-like particles (VLPs) have emerged as promising alternatives conventional inactivated vaccines due their exceptional safety, efficacy, ability provide multi-disease protection with a single dose.Our study focused on specific...
ABSTRACT Viruses exploit the host cell’s energy metabolism system to support their replication. Mitochondria, known as powerhouse of cell, play a critical role in regulating cell survival and virus Our prior research indicated that classical swine fever (CSFV) alters mitochondrial dynamics triggers glycolytic metabolic reprogramming. However, mechanism PKM2, key regulatory enzyme metabolism, CSFV replication remain unclear. In this study, we discovered enhances PKM2 expression utilizes...
Over the past 20 years, Seneca Valley virus (SVV) has emerged in various countries and regions around world. Infected pigs display symptoms similar to foot-and-mouth disease other vesicular diseases, causing severe economic losses affected countries. In recent number of SVV infections been increasing Brazil, China, United States. this study, we comprehensively analyzed genomic sequence data from perspectives evolutionary dynamics, phylogeography, codon usage bias. We aimed gain further...
Since the introduction of feline panleukopenia virus (FPV) vaccine in China 2011, it has played a crucial role safeguarding health numerous pet cats by preventing FPV infections. However, an observed rise infections among previously vaccinated prompted our investigation. Our laboratory identified specific isolate, FPV-251, which raises concerns about its potential to evade immune response. To validate this hypothesis, we conducted correlational study on FPV-251. Ten sera samples were...
Foot-and-mouth disease virus (FMDV) is a highly contagious and devastating that infects cloven-hoofed livestock various wildlife species. Vaccination the best measure to prevent FMD. ADDomer, as kind of non-infectious adenovirus-inspired nanoparticle, has advantage high thermal stability. In this study, two dominant B-cell antigen epitopes (residues 129~160 200~213) T-cell epitope 16~44) type O FMDV were inserted into ADDomer variable loop (VL) arginine-glycine-aspartic acid (RGD) loop. The...
Porcine circovirus type 2 (PCV2) is capable of causing porcine circovirus-associated disease (PCVAD) and one the major threats to global pig industry. The nucleocapsid protein Cap encoded by PCV2 ORF2 gene an ideal antigen for development subunit vaccines, its N-terminal nuclear localization sequence (NLS) structural domain essential formation self-assembling VLPs. In present study, we systematically expressed characterized full-length proteins fused dominant T B cell antigenic epitopes...
Recently, the emergence of HP-PRRSV (Highly Pathogenic porcine reproductive and respiratory syndrome virus) exacerbation mixed infections PRRSV PCV have resulted in significant economic losses for Chinese pig industry. This study collected a total 226 samples suspected infection with aforementioned viruses from diverse farms seven urban districts central northern Guangdong Province between 2020 2022. The positive rates PRRSV, PCV2, PCV3 were 33.2%, 37.6%, 7.5%, respectively, there various...
Japanese encephalitis is a mosquito-borne zoonotic epidemic caused by the virus (JEV). JEV not only leading cause of Asian viral encephalitis, but also one causes worldwide. To understand genetic evolution and E protein characteristics JEV, 263 suspected porcine JE samples collected from South China 2011 to 2018 were inspected. It was found that 78 aborted fetuses JEV-nucleic-acid-positive, with positive rate 29.7%. Furthermore, four variants isolated JEV-nucleic-acid-positive materials,...
Feline calicivirus (FCV) is one of the most important pathogens causing upper respiratory tract diseases in cats, posing a serious health threat to these animals. At present, FCV mainly prevented through vaccination, but protective efficacy vaccines China limited. In this study, based on differences capsid proteins isolates from different regions China, as reported our previous studies, seven representative epidemic strains were selected and tested for their viral titers, virulence,...
Since the beginning of 21st century, humans have experienced three coronavirus pandemics, all which were transmitted to via animals. Recent studies found that porcine deltacoronavirus (PDCoV) can infect humans, so swine enteric (SeCoV) may cause harm through cross-species transmission. Transmissible gastroenteritis virus (TGEV) and PDCoV caused tremendous damage loss pig industry around world. Therefore, we analyzed genome sequence data these two SeCoVs by evolutionary dynamics...
Abstract • Background: Reproductive disorders and multiple organ damage in pigs can be caused by various pathogens. Among them, Porcine Respiratory Syndrome Virus (PRRSV) Circovirus Type 2 (PCV2) 3 (PCV3) have coexisted Chinese pig farms for over 20 years. Recently, the emergence of new outbreaks these three viruses indicates possible changes their genetic characteristics. Results: We conducted detection isolation suspected PRRSV Circovirus(PCV) infections from Guangdong Province between...