Traditional and herbal medicines are the most easily available health care remedy in African countries. The use of medicinal plants began centuries due to their accessibility. Melastomastrum capitatum is a plant Mambila plateau Taraba State, Nigeria for treating many diseases notably ovarian cancer traditional medicine. Decoction leaf mostly used this case. This study was carried out order determine bioactive compounds present methanol extract M. by using GC–MS machine. Eight hundred gram...

This work outlines the design, synthesis, and biological evaluation of a new series benzimidazole/1,2,3-triazole hybrids as apoptotic antiproliferative agents that inhibit EGFR pathway. The research assesses efficacy compounds 6a-i 10a-i against various cancer cell lines. emphasizing 6i 10e for their remarkable activity, with GI50 values 29 nM 25 nM, respectively. inhibitory effects most potent 6e, 6i, 10d, 10e, 10g on were assessed. Compounds exhibited greater potency than erlotinib...

Due to the shortcomings associated with modern synthetic antidiarrhoeal drugs, it is important find newer, safer and cheaper agents from natural sources. The study was conducted evaluate anti-diarrhoeal activity of fractions stem-bark Terminalia avicennioides in laboratory animal models. effect different concentrations (1.0 × 10-3, 2.0 4.0 10-3 8.0 mg/mL) aqueous methanol (AMF), ethyl acetate (EAF) hexane (HXF) T. were tested against spontaneous acetylcholine-induced contractions rabbit...

The rapid epidemiological progression of obesity worldwide has been associated with increased consumption diets, rich in fat and sugar. Mediterranean diets resveratrol are reduced risk oxidative stress. aim the experiment was to investigate protective effect on high diet (HFD) induced stress changes rabbits. Thirty rabbits divided into six groups five animals each were used for experiment: Group 1 = control (C), 2 only, 3 200 mg/kg (R200), 4 400 (R400), 5 HFD + R200 group 6 R400. After four...

Cereal food waste makes up a significant part of municipal solid waste, and its proper treatment has become an urgent issue due to increasing generation. In Nigeria, where around 50% is organic, this study focuses on the need for effective management. It highlights negative environmental economic impacts improper disposal methods. The examines potential using cereal in anaerobic digestion biogas production. was collected from student hostels at College Nursing Midwifery Malumfashi, sorted,...

AI has the potential to revolutionize learning and assessments. This research explored ChatGPT's in creating MCQ-based clinical pharmacy exam papers at Pharm-D level compared their quality human-made exams. In this study, three different (2 by ChatGPT; AIeasy & AIhard, 1 instructor; HUMAN) were set have 10 MCQs each. We asked ChatGPT one with a low of difficulty (AIeasy) second specific instructions achieve more difficult (AIhard). Students attempted these exams as part regular assessment...

Serum adiponectin concentration is inversely associated with leptin and insulin concentration. There little paucity of information in the literature on adipokine levels regulation by resveratrol cholesterol diet-fed animals. Thirty rabbits were randomly divided into six groups, each five animals: Group 1 = control (C), 2 diet (CD) only, 3 200 mg/kg (R200), 4 400 (R400), 5 CD + R200, 6 R400. The preparations administered for 8th weeks treatment protocol. weight blood glucose level measured...

Abstract Background Azadirachta indica , Khaya senegalensis Anogeissus leiocarpus and Tamarindus are important ethnomedicinal plants used for health mitigation since the history of mankind. They discretionarily in folkloric medicine on premise that they natural products devoid synthetic preservatives. However, nature endows with metabolites warding off potential attacks from animals environment. Some these responsible toxicity some plants. Furthermore, drug-induced liver injuries...

Abstract Background Adansonia digitata L. (Malvaceae) is used locally in the management of depressive illnesses, and its antidepressant-like effect has been previously reported. The present study was aimed at determining methanol extract stem bark A . (MEAD) on chronic unpredictable mild stress (CUMS) possible mechanism responsible for antidepressant activity. Methods Acute toxicity MEAD determined using OECD guideline 420. CUMS model to induce depression, behavioral tests such as sucrose...

Pharacognostic investigation of the fresh, powdered and anatomical sections leaves Gisekia pharnacioides Linn was carried out to determine its macro- microscopical characters also some physical constants. Externally, possess a symmetrical base, an entire margin, obtuse apex pilose surface. Internally, shows presences anisocytic stomata, unicellular, uniseriated-covering trichomes with swollen base acute apex, prism clustered crystals calcium oxalate fiber elements. The chemo-microscopy...

Aim: Diospyros mespiliformis is one plant used by the natives for treatment of certain diseases including wounds. In this present study, preliminary screening methanolic leaf extract D. was carried out its phytochemical and proximate constituents in addition to investigating antimicrobial activity against four bacteria species. Methodology: Preliminary analysis were using standard methods. The conducted whole in-plate broth serial micro dilution assays on two Gram positive (Staphylococcus...

Utilization of compounds in extracts derived from medicinal plants is vogue now for managing Meloidogyne incognita on crops owing to the unpopular use synthetic nematicides especially Sub-Saharan Africa. In this study, Azadirachta indica A. Juss and Hyptis suaveolens obtained using hexane, chloroform, ethyl acetate methanol were tested their efficacy inhibiting egg hatching inducing larval mortality tomato bioassay maintained Screenhouse. The each solvent reconstituted...

Context Global studies on Argemone mexicana L. (Papaveraceae) traditionally used against malaria in Mali are limited to its low-mass compounds activities, and little information bioactive polysaccharides is available.Objective This study determines the structure immunomodulatory activity of from aerial parts A. mexicana.Materials methods Acidic this plant material named HMAmA1 HMAmA2 were isolated water extracts. Their monosaccharide composition was determined by gas chromatography....

This study investigated the phytoconstituents in Neem (seed and flower), Jatropha curcas (stem root bark) grape bark leaves) some selected solvents. Phytochemical screening revealed presence of bioactive compound saponin all parts three plants water extract only. Saponin was absent other solvents used (ethanol, ethyl acetate, propan-2-ol, methanol, n-butanol acetone). Ethanol, acetate methanol were most promising to flavonoids both seed flower plant. Acetone ethanol stem J. curcas. In...

Introduction: Diabetes mellitus has remained one of the serious health problems in world; and oxidative stress been reported to be a root cause for progression development diabetes its associated complications. Aim: This study investigated possible ameliorative effects lycopene on diabetic-induced changes erythrocyte osmotic fragility lipid peroxidation Wistar rats. Methodology: The animals were made diabetic by single intraperitoneal injection streptozotocin at 60 mg/kg b w. was confirmed...

Aim:The study was designed to investigate the hypoglycaemic potential of lycopene in streptozotocin (STZ)-induced diabetic Wistar rats.Methodology: To achieve this, a total thirty (30) adult rats both sexes were used.The animals made by single intraperitoneal injection freshly prepared (60 mg/kg body weight) STZ.Diabetes confirmed presence high blood glucose ≥ 200 after 72 hr.Diabetic divided into six ( 6) groups (1, 2, 3, 4, 5 and comprising five each.Animals Group 1 (Diabetic control) 2...