A5011628340- Natural Antidiabetic Agents Studies
- Pharmaceutical Practices and Patient Outcomes
- Endoplasmic Reticulum Stress and Disease
- Medicinal Plants and Neuroprotection
- Phytochemistry and Biological Activities
- Pancreatic function and diabetes
- Mosquito-borne diseases and control
- Pharmacological Effects of Natural Compounds
- Food Chemistry and Fat Analysis
- African Botany and Ecology Studies
- Stress Responses and Cortisol
- Diverse Scientific Research Studies
- Pneumonia and Respiratory Infections
- Phytochemistry and Bioactive Compounds
- Drug-Induced Hepatotoxicity and Protection
- Child Nutrition and Water Access
- Tryptophan and brain disorders
- Antibiotic Use and Resistance
- Autophagy in Disease and Therapy
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Ethnobotanical and Medicinal Plants Studies
- Visual and Cognitive Learning Processes
- Oil, Gas, and Environmental Issues
- Cholinesterase and Neurodegenerative Diseases
Ahmadu Bello University
2011-2023
Bayero University Kano
2022
African Field Epidemiology Network
2021
University of Benin
2020
Sports University of Tirana
2018
University of Agriculture Faisalabad
2009
Abstract Background Adansonia digitata L. (Malvaceae) is used locally in the management of depressive illnesses, and its antidepressant-like effect has been previously reported. The present study was aimed at determining methanol extract stem bark A . (MEAD) on chronic unpredictable mild stress (CUMS) possible mechanism responsible for antidepressant activity. Methods Acute toxicity MEAD determined using OECD guideline 420. CUMS model to induce depression, behavioral tests such as sucrose...
Objective: This work aimed to describe attitudes and practices of both community pharmacies patent proprietary medicine vendor (PPMV) outlets towards over-the-counter (OTC) analgesic use for musculoskeletal pain states within Zaria, Nigeria. Methods: The study was carried out in 2 phases from May August 2016. Phase one a cross-sectional survey 40 retail drug (10 30 PPMVs). A simulated patient scenario young adult male complaining acute onset back used collect data on the type quality...
The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis insulin-secreting beta-cells is essential. Several pathophysiological conditions pharmacological agents disrupt the homeostasis, thereby causing stress. cells react to stress by initiating an adaptive signaling process called unfolded response (UPR). However, initiates death pathways whenever persists. has been linked several...
Pharmaceutical pictograms are standardized images used to visually convey medication instructions. Very little is known about the ability of Africans interpret these images.Thus, aim this study was assess guessability (ability correctly guess meaning) selected International Federation (FIP) and United States Pharmacopoeia (USP) in members Nigerian public.A cross-sectional survey carried out between May August 2021 on 400 randomly sampled public. Selected (24 FIP 22 USP pictograms) were...
Well trained, knowledgeable and competent pharmacists are indispensable in the fight against antimicrobial resistance (AMR), which is a current global public health problem. The aim of this work was to assess knowledge antibiotics, stewardship fifth year pharmacy students at three universities Northern Nigeria.
Purpose: To study the involvement of inflammatory pathways in antidepressant activity Acacia seyal mice.Methods: The median lethal dose (LD50) extract (AS) was determined using OECD guideline 425. AS assessed against BCG (0.2 mg/kg, ip)-induced depression mice Tail suspension test (TST) and open field (OFT) at 4, 24 48 hours post administration.Results: for > 5000 mg/kg orally. all tested doses (250 – 1000 mg/kg) significantly (p ≤ 0.001) decreased duration immobility TST but increased...
Background: Over the years, scope of practice for pharmacy profession has considerably broadened and several areas can now be chosen by young graduates. However, not much is known about career preferences Nigerian students.Objectives: To explore factors influencing choice a degree, perceptions in final year students at selected universities Northern Nigeria.Methods: A cross sectional study using structured paper-based questionnaire to collect data from consenting six universities, was...
Abstract Background Parquetina nigrescens (Afzel) Bullock is a commonly used medicinal plant in African traditional medicine. The powdered roots and stems of the are taken with pap as memory enhancer among Yorubas southwestern Nigeria. mechanism by which scopolamine induces cognitive deficit mimics pathogenesis neurodegeneration impairment. This study therefore, aimed at investigating effect methanol stem extract P . on sub-chronically scopolamine-induced mice. Method Phytochemical screening...
Introduction: Hausa people of north-western Nigeria were reported to utilize the plant Adansonia digitata for management depressive illnesses in an ethnobotanical survey. Thus, this study aimed establish mechanism(s) via which methanol stem bark extract A. (MEAD) exhibits antidepressant activity mice. Methods: Antidepressant MEAD was evaluated using tail suspension test (TST) at doses 250, 500 and 1000 mg/kg. For mechanistic studies, mice pre-treated with sulpiride (50 mg/kg), prazosin (1...
Oxidative stress is crucial in the pathophysiology of many inflammatory disorders. Medicinal plants contain phytoconstituents which have been linked to response within body due their antioxidant capacity. The purpose this study was investigate protective effect Hymenodictyon floribundum ethanol leaf extract (ELHF) on inflammation-induced oxidative rats. Phytochemical screening and acute toxicity effects ELHF were assessed using established procedures. induction by cotton pellet-induced...
This study aimed at providing pharmacological rationale for the ethnomedicinal use of Parquetina nigrescens root in treatment diarrhoea. The antidiarrhoeal activity methanol extract P. nigrescens(MPN) was determined using castor oil-induced diarrhoea (COD), enteropooling (COE) and gastrointestinal motility (GIT) tests. In COD, MPN all doses significantly (p≤0.01) delayed onset (p≤0.05) decreased number wet faeces (with percentage inhibition 52.2; 53.33 71.13 25, 50 100 mg/kg) respectively....
Senna italica Mill. belonging to the family Fabaceae has been used traditionally treat various ailments diseases including skin diseases, fever, jaundice, stomachache, burns and inflammation. The aim of present study was evaluate phytochemical profile anti-inflammatory activity methanol leaf extract plant. Preliminary screening oral acute toxicity studies were carried out using standard protocols. Anti-inflammatory investigated in Wistar rats cotton pellet-induced granuloma model at doses...
Securinega virosa (S. virosa) is a commonly used medicinal plant in Africa for the management of psychiatric illnesses. Thus, current study aimed at evaluating antidepressant activity methanol extract S. mice. The acute toxicity and phytochemical profiles were also determined. (500, 250 125 mg/kg) was assessed using tail suspension test(TST), forced swim test (FST) open field (OFT).The median lethal dose estimated to be ≤2000 mg/kg. Phytoconstituents like tannins, saponins, flavonoids,...
Caralluma dalzielli N.E. Br (Asclepidiaceae) is reportedly used in the management of depression by traditional practitioners Northwestern Nigeria. However, there paucity data literature on antidepressant potential plant scientifically. The aim work was to provide scientific rationale for use depressive illnesses locally. Preliminary phytochemical screening conducted using thin layer chromatography (TLC), acute toxicity study (LD50) OECD guideline 425 and beam walking assay (BWA) assess...