A5044842808- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Eicosanoids and Hypertension Pharmacology
- Traditional and Medicinal Uses of Annonaceae
- Endoplasmic Reticulum Stress and Disease
- Hormonal Regulation and Hypertension
- Autophagy in Disease and Therapy
- Fatty Acid Research and Health
- Traditional Chinese Medicine Analysis
- Antioxidant Activity and Oxidative Stress
- Receptor Mechanisms and Signaling
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- Biochemical and Structural Characterization
- Cancer-related Molecular Pathways
- Sirtuins and Resveratrol in Medicine
- Bioactive natural compounds
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Flavonoids in Medical Research
- Cardiac Ischemia and Reperfusion
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Aligarh Muslim University
2021-2025
Jawaharlal Nehru Medical College Hospital
2021-2025
University of Malaya
2013-2022
University of Hong Kong
2017
Umaru Musa Yar'adua University
2017
Damietta University
2014
University Malaya Medical Centre
2000
Dengue is a major mosquito-borne disease currently with no effective antiviral or vaccine available. Effort to find antivirals for it has focused on bioflavonoids, plant-derived polyphenolic compounds many potential health benefits. In the present study, activity of four types bioflavonoid against dengue virus type -2 (DENV-2) in Vero cell was evaluated. Anti-dengue these determined at different stages DENV-2 infection and replication cycle. DENV measured by Foci Forming Unit Reduction Assay...
Japanese encephalitis (JE), a mosquito-borne viral disease, is endemic to the entire east and southeast Asia, some other parts of world. Currently, there no effective therapeutic available for JE; therefore, finding antiviral agent against JEV replication crucial. In present study, in vitro activity baicalein quercetin, two purportedly bioflavonoids, was evaluated virus (JEV) Vero cells. Anti-JEV activities these compounds were examined on different stages cycle. The effects determined by...
Abstract Background Dengue is a serious arboviral disease currently with no effective antiviral therapy or approved vaccine available. Therefore, finding the compound against dengue virus (DENV) replication very important. Among natural compounds, bioflavonoids derived mainly from plants are of interest because their biological and medicinal benefits. Methods In present study, activity bioflavonoid, baicalein, was evaluated different stages type 2 (DENV-2) in Vero cells using focus forming...
A prior screening programme carried out using MTT assay by our group identified a series of novel benzimidazole derivatives, among which Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) showed highest anticancer efficacy compared to that chemotherapeutic agent, cisplatin. In the present study, we found MBIC inhibited cell viability in different hepatocellular carcinoma (HCC) lines without exerting significant cytotoxic effects on normal liver cells. Annexin...
Hypertension increases the risk for a variety of cardiovascular diseases, including stroke, coronary artery disease, heart failure, and peripheral vascular disease. The increase in oxidative stress has been associated with pathogenesis hypertension. Increase blood pressure is due to an imbalance between antioxidants defence mechanisms free radical productions. Excessive production reactive oxygen species reduces nitric oxide bioavailability leading endothelial dysfunction subsequent total...
Background Alpha-tomatine (α-tomatine) is the major saponin in tomato (Lycopersicon esculentum). This study investigates chemopreventive potential of α-tomatine on androgen-independent human prostatic adenocarcinoma PC-3 cells. Methodology/Principal Findings Treatment highly aggressive prostate cancer cells with resulted a concentration-dependent inhibition cell growth half-maximal efficient concentration (EC50) value 1.67±0.3 µM. It also less cytotoxic to normal liver WRL-68 and RWPE-1...
In the present study we investigated effects of panduratin A, isolated from Boesenbergia rotunda, on proliferation and apoptosis in A549 human non-small cell lung cancer cells. Cell induction was determined by real-time cellular analyzer (RTCA), MTT assay High Content Screening (HCS). The RTCA indicated that A exhibited cytotoxicity, with an IC50 value 4.4 µg/mL (10.8 µM). Panduratin arrested cells labeled bromodeoxyuridine (BrdU) phospho-Histone H3 mitotic phase. cytotoxic were found to be...
Flavonoids are known to possess cardioprotective properties. Vascular endothelial function is a surrogate marker for cardiovascular diseases, including hypertension. We have studied the effects of chronic flavonoid treatment on vascular functions in spontaneously hypertensive rats (SHR). Starting from 6-7 weeks old, SHR were given flavonoids (baicalein, flavone, or quercetin) orally (10 mg/kg, once daily) SHRs 4 weeks. Aortas all flavonoid-treated animals showed remarkably higher...
Oxidization of dietary cooking oil increases the risk cardiovascular diseases such as hypertension by increasing formation oxidative oxygen radicals. The aim study was to investigate effects repeatedly heated palm on blood pressure, plasma nitrites, and vascular reactivity. Nitrites were measured, an indirect marker for nitric oxide production. Male Sprague-Dawley rats divided into four groups: control group fed with basal diet other three groups fortified 15% weight/weight fresh (FPO), five...
Boldine is a potent natural antioxidant present in the leaves and bark of Chilean boldo tree. Here we assessed protective effects boldine on endothelium range models diabetes, ex vivo vitro.Vascular reactivity was studied mouse aortas from db/db diabetic normal mice. Reactive oxygen species (ROS) production, angiotensin AT1 receptor localization protein expression oxidative stress markers vascular wall were evaluated by dihydroethidium fluorescence, lucigenin enhanced-chemiluminescence,...
The goal of this study was to determine the possible mechanism that is involved in blood pressure-raising effect heated vegetable oils. Adult male Sprague-Dawley rats were divided into 11 groups; control group fed with rat chow, and other groups chow mixed 15% weight/weight palm or soy oils, which either a fresh form once, twice, five, ten times. Blood pressures measured at baseline throughout 24-week study. Plasma nitric oxide levels assessed prior treatment end Following 24 weeks,...
Angiotensin 1–7 (Ang 1–7) counter-regulates the cardiovascular actions of angiotensin II II). The present study investigated protective effect Ang against II-induced endoplasmic reticulum (ER) stress and endothelial dysfunction. Ex vivo treatment with (0.5 μM, 24 hours) impaired endothelium-dependent relaxation in mouse aortas; this harmful was reversed by co-treatment ER inhibitors, l4-phenylbutyric acid (PBA) tauroursodeoxycholic (TUDCA) as well 1–7. Mas receptor antagonist, A779,...