A5076805273- Genomics, phytochemicals, and oxidative stress
- Phytochemicals and Antioxidant Activities
- Helicobacter pylori-related gastroenterology studies
- Cancer Mechanisms and Therapy
- Wnt/β-catenin signaling in development and cancer
- Phytochemical compounds biological activities
- Natural product bioactivities and synthesis
- Nanoparticles: synthesis and applications
- Pharmacological Effects of Natural Compounds
- Tannin, Tannase and Anticancer Activities
- Garlic and Onion Studies
- Bioactive Compounds and Antitumor Agents
- Inflammatory Bowel Disease
- Bone Tissue Engineering Materials
- FOXO transcription factor regulation
- Cholinesterase and Neurodegenerative Diseases
- Phytase and its Applications
- Electrospun Nanofibers in Biomedical Applications
- Inflammatory mediators and NSAID effects
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Curcumin's Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Flavonoids in Medical Research
- Moringa oleifera research and applications
B.S. Abdur Rahman Crescent Institute of Science & Technology
2017-2025
University of Malaya
2015-2018
Universiti Putra Malaysia
2013-2018
Zero to Three
2014
Serdang Hospital
2014
University of Madras
2012-2013
Oakland University
2012
Growing evidence supports a link between inflammation and cancer; however, mediators of the transition carcinogenesis remain incompletely understood. Sphingosine-1-phosphate (S1P) lyase (SPL) irreversibly degrades bioactive sphingolipid S1P is highly expressed in enterocytes but downregulated colon cancer. Here, we investigated role SPL colitis-associated cancer (CAC). We generated mice with intestinal epithelium-specific Sgpl1 deletion chemically induced colitis tumor formation these...
Gallic acid (GA) is a polyhydroxy phenolic compound that has been detected in various natural products, such as green tea, strawberries, grapes, bananas, and many other fruits. In inflammatory bowel disease, inflammation promoted by oxidative stress. GA strong antioxidant; thus, we evaluated the cytoprotective anti-inflammatory role of dextran sulfate sodium (DSS)-induced mouse colitis model. Experimental acute was induced male BALB/c mice administering 2.5% DSS drinking water for 7 days....
Abstract: Chitosan (CS) iron oxide magnetic nanoparticles (MNPs) were coated with phytic acid (PTA) to form acid-chitosan-iron nanocomposite (PTA-CS-MNP). The obtained and nanocarrier characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, vibrating sample magnetometry, transmission electron microscopy, thermogravimetric differential analyses. spectra thermal analysis of MNPs PTA-CS-MNP confirmed the binding CS on surface loading PTA in nanocomposite. coating...
Natural products are considered potent sources for novel drug discovery and development. The multiple therapeutic effects of natural compounds in traditional medicine motivate us to evaluate the cytotoxic activity bulb Allium atroviolaceum MCF7 MDA-MB-231, HeLa HepG2 cell lines. methanol extract A. was found be an active proliferation inhibitor at time dose dependent manner. Determination DNA content by flow cytometry demonstrated S G2/M phase arrest MCF-7 cell, correlated Cdk1...
The present study describes a method for the preparation of green titanium dioxide (TiO2) nanoparticles from peel Solanum tuberosum, commonly known as potato, and potato being kitchen waste. synthesized TiO2 (G- TiO2) were characterized using UV-visible spectroscopy, dynamic light scattering, scanning electron microscopy, TEM, XRD, FTIR spectroscopy. photocatalytic activity G- was also shown dye bromophenol blue. To explore biocompatibility TiO2, cell viability in normal well cancer cells...
The objective of this study is to evaluate the effect allicin (10 mg/kg body weight, orally) in an experimental murine model UC by administering 2.5% dextran sodium sulfate (DSS) drinking water BALB/c mice. DSS-induced mice presented reduced which was improved administration. We noted increases CD68 expression, myeloperoxidase (MPO) activities, and Malonaldehyde (MDA) mRNA levels proinflammatory cytokines, such as tumor necrosis factor- (TNF-) α , interleukin- (IL-) 1 β IL-6 IL-17 decrease...
Abstract Colorectal cancer (CRC) is the third most common malignancy in males and second worldwide. Chronic colonic inflammation a known risk factor for CRC. Cocoa contains many polyphenolic compounds that have beneficial effects humans. The objective of this study to explore antioxidant properties cocoa mouse model azoxymethane (AOM)/dextran sulfate sodium (DSS)‐induced colitis‐associated cancer, focusing on activation Nrf2 signaling. Mice were treated with AOM/DSS randomized receive either...
Colorectal cancer (CRC) is now perceived as a multistep process characterized by the accumulation of genetic alterations in oncogenes and tumor suppressor genes. Plant-derived compounds are receiving considerable attention for their potential role reducing risk. Luteolin, bioflavonoid present many fruits vegetables, possesses antioxidant, anti-inflammatory antiproliferative properties. This study was designed to investigate possible luteolin administration on Phase 1 2 enzymes NF-E2-related...
Sphingadienes (SDs) derived from soy and other natural sphingolipids are cytotoxic to colon cancer cells via an Akt-dependent mechanism reduce adenoma formation in ApcMin/+ mice. Wnt signaling is fundamental carcinogenesis the basis for spontaneous tumorigenesis mice patients with familial adenomatous polyposis. In present study, we investigated impact of SDs on signaling. Oral SD administration reduced levels active β-catenin targets c-Myc cyclin D1 mouse intestinal tissues. Colon treated...
Cancer is a multistep process that typically occurrs over an extended period of time, beginning with initiation followed by promotion and progression. Colon cancer the leading cause morbidity mortality worldwide. For variety reasons, patients prefer naturally occurring dietary substances synthetic agents to prevent cancer. Luteolin, bioflavonoid, possesses antioxidant, anti-inflammatory, antiproliferative effects. We analyzed in vitro anticancer apoptosis-inducing property luteolin using...
Bone tissue engineering offers a viable alternative to traditional bone and chondral transplant procedures, promoting new formation for persistent repair remodelling in complex cartilage lesions. To foster repair, this study explores novel chitosan-based scaffold incorporating quercetin hydroxyapatite (HAP) treating articular defects. Chitosan, biopolymer with natural flavonoid quercetin, has been shown influence cell signalling pathways, division, proliferation, apoptosis, while HAP, an...
Introduction: Alcoholic liver disease encompasses a variety of unusual occurrences, starting with rare cases alcoholic steatosis, which eventually led to the development in addition cirrhosis, and steatohepatitis. Natural products are suitable candidates for treatment ALD. Background: Since, Leucas aspera has high concentration antioxidants, including flavonoids phenolic compounds, it been investigated its ability counteract oxidative stress. In this work, we sought understand role that...
Nutritional or dietary factors have drawn attention due to their potential as an effective chemopreventive agent, which is considered a more rational strategy in cancer treatment. This study was designed evaluate the effect of IP₆ extracted from rice bran on azoxymethane- (AOM-) induced colorectal (CRC) rats. Initially, male Sprague Dawley rats were divided into 5 groups, with 6 each group. The received two intraperitoneal (i.p.) injections AOM saline (15 mg/kg body weight) over 2-week...
Luteolin (LUT), a bioflavonoid has been used as chemopreventive agent world-wide against chemically induced cancer. Hence we designed an experiment to assess action of LUT on lipid peroxidation (LPO) and glycoconjugates in azoxymethane (AOM)-induced colon carcinogenesis. Colon cancer was by 15 mg/body kg. body weight AOM administration (at the dose 1.2 mg/kg. weight) till end study. Analysis peroxidative products such protein carbonyl (PC), malonadehyde (MDA) conjucated dienes (CD)...
Ulcerative colitis (UC) is a nonspecific inflammatory disorder characterized by oxidative and nitrosative stress, leucocyte infiltration, upregulation of mediators. Boldine an alkaloid compound found in Boldo tree, with multiple pharmacological actions, mainly anti-inflammatory, antioxidant, antitumor, immunomodulatory activities. Hence, the effect boldine for its anti-inflammatory properties against dextran sulfate sodium (DSS)-induced UC BALB/c mice was studied. Administration to...