A5061908915- Cancer, Lipids, and Metabolism
- Amyotrophic Lateral Sclerosis Research
- Prion Diseases and Protein Misfolding
- Epigenetics and DNA Methylation
- Intracerebral and Subarachnoid Hemorrhage Research
- Genomics, phytochemicals, and oxidative stress
- COVID-19 Clinical Research Studies
- Neurogenetic and Muscular Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Ferroptosis and cancer prognosis
- Inflammatory mediators and NSAID effects
- Tryptophan and brain disorders
- Phytochemical and Pharmacological Studies
- RNA Research and Splicing
- Hepatitis Viruses Studies and Epidemiology
- Natural product bioactivities and synthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related gene regulation
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- Tannin, Tannase and Anticancer Activities
- Pediatric Urology and Nephrology Studies
- Glutathione Transferases and Polymorphisms
- Genetics and Neurodevelopmental Disorders
- Protease and Inhibitor Mechanisms
Houston Methodist
2016-2025
Saveetha University
2021-2022
Jai Prakash Vishwavidyalaya
2018
University of Madras
2013-2014
Abstract TDP-43 mislocalization and aggregation are key pathological features of amyotrophic lateral sclerosis (ALS)- frontotemporal dementia (FTD). However, existing transgenic hTDP-43 WT or ∆NLS-overexpression animal models primarily focus on late-stage proteinopathy. To complement these to study the early-stage motor neuron-specific pathology during pre-symptomatic phases disease progression, we generated a new endogenous knock-in (KI) mouse model using combination CRISPR/Cas9 FLEX...
Colon cancer (CRC) is a serious health problem through worldwide. Development of novel drug without side effect for this was crucial. Luteolin (LUT), bioflavonoid has many beneficial effects such as antioxidant, anti-inflammatory, anti-proliferative properties. Azoxymethane (AOM), derivative 1, 2-Dimethyl hydrazine (DMH) used the induction CRC in Balb/C mice. induced by intraperitoneal injection AOM to mice at dose 15 mg/body kg weight 3 weeks. Mouse treated with LUT 1.2 orally until end...
Therapy for intracerebral hemorrhage (ICH) remains elusive, in part dependent on the severity of itself as well multiple deleterious effects blood and its breakdown products such hemin free iron. While oxidative injury genomic damage have been seen following ICH, details this implications remain unclear. Here, we discovered that, while iron produced mostly reactive oxygen species (ROS)-related single-strand DNA breaks, unexpectedly induced rapid persistent nuclear mitochondrial double-strand...
Colorectal cancer (CRC) is now perceived as a multistep process characterized by the accumulation of genetic alterations in oncogenes and tumor suppressor genes. Plant-derived compounds are receiving considerable attention for their potential role reducing risk. Luteolin, bioflavonoid present many fruits vegetables, possesses antioxidant, anti-inflammatory antiproliferative properties. This study was designed to investigate possible luteolin administration on Phase 1 2 enzymes NF-E2-related...
Cancer is a multistep process that typically occurrs over an extended period of time, beginning with initiation followed by promotion and progression. Colon cancer the leading cause morbidity mortality worldwide. For variety reasons, patients prefer naturally occurring dietary substances synthetic agents to prevent cancer. Luteolin, bioflavonoid, possesses antioxidant, anti-inflammatory, antiproliferative effects. We analyzed in vitro anticancer apoptosis-inducing property luteolin using...
The present investigation deals with the antimetastatic role of luteolin (LUT) by inhibiting matrix metalloproteinase (MMP)-9 and -2 in azoxymethane (AOM)-induced colon carcinogenesis Balb/C mice. Animals received AOM at a dosage 15 mg/kg body weight intraperitoneally once week for 3 weeks. AOM-induced mice was treated LUT (1.2 mg LUT/kg weight/day orally). After experimental period, tumor markers such as γ-glutamyl transferase (GGT), 5' nucleotidase (5'ND), cathepsin-D (Cat-D),...
Luteolin (LUT), a bioflavonoid has been used as chemopreventive agent world-wide against chemically induced cancer. Hence we designed an experiment to assess action of LUT on lipid peroxidation (LPO) and glycoconjugates in azoxymethane (AOM)-induced colon carcinogenesis. Colon cancer was by 15 mg/body kg. body weight AOM administration (at the dose 1.2 mg/kg. weight) till end study. Analysis peroxidative products such protein carbonyl (PC), malonadehyde (MDA) conjucated dienes (CD)...
Abstract Coronavirus disease‐2019 (COVID‐19) is a global pandemic and caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which has resulted in millions of deaths worldwide. Reports denote SARS‐CoV‐2 uses angiotensin‐converting enzyme (ACE2), transmembrane serine protease (TMPRSS2) as its primary entry point into the host cell. However, understanding biology behind this viral replication, disease mechanism drug discovery efforts are limited due to lack suitable...
Abstract TDP-43 mislocalization and aggregation are key pathological features of motor neuron diseases (MND) such as amyotrophic lateral sclerosis (ALS) frontotemporal dementia (FTD). However, existing overexpression animal models typically capture late-stage proteinopathies, leaving a gap in our understanding early neuron-specific disease mechanisms during pre-symptomatic phases. We address this by generating new endogenous knock-in (KI) mouse model using combination CRISPR/Cas9 FLEX...
Abstract TDP-43 mislocalization and aggregation are key pathological features of motor neuron diseases (MND) including amyotrophic lateral sclerosis (ALS) frontotemporal dementia (FTD). However, transgenic hTDP-43 WT or ∆NLS-overexpression animal models mainly capture late-stages proteinopathy, do not provide a complete understanding early neuron-specific pathology during pre-symptomatic phases. We have now addressed this shortcoming by generating new endogenous knock-in (KI) mouse model...
Colon cancer (CRC) is a serious health problem throughout the world. Development of novel drugs without side effects for this crucial. Luteolin (LUT), bioflavonoid, has many beneficial such as antioxidant, anti-inflammatory and anti-proliferative potential. was potent chemical carcinogen used induction colon cancer. carcinogenesis initiated by intraperitoneal injection azoxymethane (AOM) to mice at dose 15 mg/body kg weight in Balb/C 3 weeks. Mice were treated with LUT 1.2 orally....
Background and Purpose: Lack of suitable experimental models hinders SARS-CoV-2 research. Reports denote uses ACE2, TMPRSS-2 as its primary receptors. However, clinical symptoms were also related to organs with poor or no expressions Hence, using single-cell RNA sequencing data human organoids, we analyzed expression levels receptors array for their involvement in pathogenesis. Experimental Approach: From the gene omnibus (GEO) express database, normalized cell counts intestine coventional,...
Introduction: An attractive treatment target following intracerebral hemorrhage (ICH) are reactive oxidative stress (ROS) reactions occurring after contact with blood breakdown products, such as hemin and iron. Recent work suggests the ferroptosis cell death pathway predominates ICH, likely secondary to ROS free iron consuming key protection pathways. While studies directed at deferoxamine (DEF) underway, DEF suffers from poor cellular uptake, short shelf life toxicity. We report a new...