Alzheimer's disease (AD) is a progressive neurodegenerative for which there lack of effective therapeutic drugs. There great potential natural products to be used in the development anti-AD P-coumaric acid (PCA), small molecule phenolic widely distributed plant kingdom, has pharmacological effects such as neuroprotection, but its mechanism not been fully elucidated. In current study, we investigated PCA intervention Aβ25-35-induced AD model using gut microbiomics and serum metabolomics...

Designing cyber-physical systems (CPS) is challenging due to the tight interactions between software, network/platform, and physical components. A co-simulation method valuable enable early system evaluation. In this paper, a framework that considers interacting CPS components for design of time-triggered (TT) proposed. Virtual prototyping core proposed framework. network/platform model in SystemC forms backbone virtual prototyping, which bridges control software environment. The consists...

The systematic design of automotive control applications is a challenging problem due to lack understanding the complex and tight interactions that often manifest during integration components from phase with software generation deployment on actual platform/network. In order address this challenge, we present methodology toolchain using well-defined models integrate various phases specific emphasis restricting such as timing, deployment, quantization. We an experimental platform for...

The rowhammer bug belongs to software-induced hardware faults, and has posed great security challenges numerous systems. On x86, many approaches triggering the have been found; yet, due several different reasons, number of discovered on ARM is limited. In this paper, we revisit problem how trigger ARM-based devices by carefully investigating whether it possible translate original x86-oriented ARM. We provide a thorough study unprivileged ARMv8-A cache maintenance instructions give two...

The Bayan Har Group in Quanshuigou area of the northern Tibetan Plateau is regionally subdivided into three litho‐stratigraphic units, namely, upper, middle, and lower formations. In this study, we report geochemical data for fine‐grained sandstones from upper formation aiming to constrain their source weathering, provenance, palaeoenvironment, tectonic setting. exhibit similar contents SiO 2 Al O 3 relative continental crust (UCC) Post‐Archean Australian Shale classified as wacke on log...

Cache-related preemption delay (CRPD) analysis is crucial when designing embedded control systems that employ preemptive scheduling. CRPD for single-level caches has been studied extensively based on useful cache blocks (UCBs). As high-performance processors are increasingly used, which often equipped with multi-level caches, hierarchies also needs to be investigated. Recently, an approach proposed estimate non-inclusive caches. Since inclusive commonly especially in some multi-core...

When designing hard real-time embedded systems, it is required to estimate the worst-case execution time (WCET) of each task for schedulability analysis. Precise cache persistence analysis can significantly tighten WCET estimation, especially when program has many loops. Methods should safely and precisely classify memory references as persistent. Existing safe approaches suffer from multiple sources pessimism may not provide precise results. In this paper, we first identify some that two...

In this paper, we investigate how to soundly analyze multi-level caches that employ write-back policy at each level for worst-case execution time (WCET) estimation. To the best of our knowledge, there is only one existing approach dealing with write backs in cache analysis. However, as shown not sound. order handle backs, a level, need consider whether memory block potentially dirty and when such may be evicted from cache. end, introduce attribute into persistence analysis tracking blocks,...

Most existing multiprocessor schedulability analysis assumes zero cost for preemptions and migrations. In order those to be correct, execution time estimations are often inflated by a certain (pessimistic) factor, leading severe waste of computing resource. this paper, novel Global Earliest Deadline First (GEDF) test is proposed, where Cache-Related Preemption Delay (CRPD) separately modeled integrated. Specifically, multiple analyses estimating CRPD bounds conducted based on the refined...

Cyber-Physical Systems (CPS) have been increasingly subject to cyber-attacks including code injection attacks. Zero day attacks further exasperate the threat landscape by requiring a shift defense in depth approaches. With tightly coupled nature of cyber components with physical domain, these potential cause significant damage if safety-critical applications such as automobiles are compromised. Moving target techniques instruction set randomization (ISR) commonly proposed address types...

Cyber-physical systems (CPS), such as automotive systems, are very difficult to design due the tight interactions between physical dynamics, computational dynamics and communication networks. In addition, evaluation of these at early stages is crucial challenging. Model-based (MBD) approaches have been applied in order manage complexities interactions. this paper, we present a case study demonstrate systematic design, analysis an integrated control system. The system composed two...

As the number of cores and utilization system are increasing quickly, shared resources like caches interfering tasks' execution behaviors more heavily. In order to achieve resource efficiency in both temporal spatial domains for multi-core real-time systems, should be taken into consideration when performing partitions. this paper, partitioned Earliest Deadline First (EDF) scheduling on a preemptive platform is considered. We propose new model that covers inter-task cache interference...

Non-control data attacks have become widely popular for circumventing authentication mechanisms in websites, servers, and personal computers. Moreover, the context of Cyber-Physical Systems (CPS) can be executed against not only but also safety. With tightly coupled nature between cyber components physical dynamics, any unauthorized change to safety-critical variables may cause damage or even catastrophic consequences. Moving target defense (MTD) techniques such as space randomization (DSR)...

In many multi-core architectures, inclusive shared caches are used to reduce cache coherence complexity. However, the enforcement of inclusion property can cause invalidation memory blocks at higher levels. order ensure safety, analysis hierarchies with for worst-case execution time (WCET) estimation is typically based on conservative decisions. Thus, may not be tight. tighten estimation, this paper proposes an approach that more precisely analyze behavior a hierarchy maintaining property....

Gardeniae fructus (GF) is known for its various beneficial effects on cholestatic liver injury (CLI). However, the biological mechanisms through which GF regulates CLI have not been fully elucidated. This study aimed to explore potential of against α-naphthylisothiocyanate (ANIT)-induced CLI. First, HPLC technology was used analyze chemical profile extract. Second, serum biochemical indicators and histopathology were examined. Lastly, metabolomics utilized changes in metabolites clarify...

In this study, taking the Jurassic Lianggaoshan Formation (J 1 l ) tight sandstones in eastern Sichuan Basin as an example, types and well-logging responses of main sedimentological diagenetic facies lacustrine delta-front are investigated based on summarizing sedimentary characteristics reservoir properties. Subsequently, further validation application conducted study area through machine learning. Research results show that J mainly develops subaqueous distributary channels mouth bar sand...

Multi-level inclusive caches are often used in multi-core processors to simplify the design of cache coherence protocol. However, use such hierarchies poses great challenges tight worst-case execution time (WCET) estimation due possible invalidation behavior. Traditionally, multi-level analyzed a level-by-level manner, and at each level three analyses (i.e. must, may, persistence) performed separately. At particular level, conservative decisions need be made when behaviors other levels not...

When designing hard real-time embedded systems, it is required to estimate the worst-case execution time (WCET) of each task for schedulability analysis. Precise cache persistence analysis can significantly tighten WCET estimation, especially when program has many loops. Methods should safely and precisely classify memory references as persistent. Existing safe approaches suffer from multiple sources pessimism may not provide precise results. In this paper, we first identify some that two...