A5100385431- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Food Drying and Modeling
- Transcranial Magnetic Stimulation Studies
- Vagus Nerve Stimulation Research
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- EEG and Brain-Computer Interfaces
- Stress Responses and Cortisol
- Advanced Neuroimaging Techniques and Applications
- Pharmacological Effects of Natural Compounds
- Microwave-Assisted Synthesis and Applications
- Regulation of Appetite and Obesity
- Tryptophan and brain disorders
- Motor Control and Adaptation
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Marine Biology and Environmental Chemistry
- Axon Guidance and Neuronal Signaling
- Neurology and Historical Studies
- Nicotinic Acetylcholine Receptors Study
- Microencapsulation and Drying Processes
- Mental Health Research Topics
- Medicinal Plants and Neuroprotection
Northeast Agricultural University
2021-2025
Shaanxi University of Chinese Medicine
2025
Southwest Hospital
2022-2025
Chongqing Medical University
2024-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Army Medical University
2022-2025
Henan Bioengineering Technology Research Center
2022-2024
First Affiliated Hospital of Henan University
2022-2024
The University of Queensland
2023-2024
Shandong University
2019-2024
Non-invasive brain stimulation techniques, such as transcranial direct current (tDCS), are popular methods for inducing neuroplastic changes to alter cognition and behaviour. One challenge the field is optimise protocols maximise benefits. For this happen, we need a better understanding of how modulates cortical functioning/behaviour. To date, there increasing evidence dose-response relationship between tDCS excitability, however relates behaviour not well understood. Even less known about...
Foaming agents influence the feasibility of microwave-assisted foam-mat drying (MFD) for production blueberry pulp powder (BPP). In this study, effects foaming on characteristics foamed (FBP) and physicochemical indicators BPP were investigated by using formulations containing egg white (EWP, 0, 4, 8 g/100 g), maltodextrin (MD, 5, 10 g) carboxymethylcellulose (CMC, 0.5, 1 g). Results showed that co-addition EWP MD obviously influenced rate FBP. The solubility porosity increased significantly...
The receptor tyrosine kinase Tyro3 is abundantly expressed in neurons of the neocortex, hippocampus, and striatum, but its role these cells unknown. We found that neuronal expression this was markedly up-regulated postnatal mouse neocortex immediately prior to final development glutamatergic synapses. In absence Tyro3, cortical hippocampal synapses never completed end-stage differentiation remained electrophysiologically ultrastructurally immature. −/− also exhibited diminished plasma...
Spinocerebellar ataxia type 3 (SCA3) is an inherited movement disorder characterized by a progressive decline in motor coordination. Despite the extensive functional connectivity (FC) alterations reported previous SCA3 studies cerebellum and cerebellar-cerebral pathways, influence of these FC disturbances on hierarchical organization cerebellar regions remains unclear. Here, we compared 35 patients with 48 age- sex-matched healthy controls using combination voxel-based morphometry...
Spinocerebellar ataxia type 3 (SCA3), a neurodegenerative disorder caused by excess CAG repeats in the ATXN3 gene, leads to progressive cerebellar and other symptoms. The results of previous studies suggest that trace element dysregulation contributes onset. Here, we investigated relationships with repeat length, clinical severity, brain structural functional connectivity 45 patients SCA3 44 healthy controls (HCs). Blood levels lithium (Li), selenium (Se), copper (Cu) were significantly...
The widespread detection of tire wear particles (TWPs) in estuaries has heightened concerns about their potential environmental hazards. However, knowledge photoaging-induced environmentally persistent free radicals (EPFRs) formation on TWPs estuarine environments and impact sediment denitrification remains limited. This study investigated the EPFRs TWP during photoaging evaluated effects N2O accumulation using EPFR inhibitors. Results showed that 60 days illumination increased...
Xuezhikang (XZK), a red yeast rice extract with lipid-lowering effect, contains family of naturally statins, such as lovastatin. In recent years, its effect beyond the regulation lipids has also been received increasing attention. Therefore, purpose this study was to explore protective effects and possible molecular mechanisms XZK on brain injury after cardiac arrest (CA) cardiopulmonary resuscitation (CPR), investigate whether it dose-dependent difference lovastatin.Rats were treated...
Abstract Sensory nerves play a crucial role in maintaining bone homeostasis by releasing Semaphorin 3A (Sema3A). However, the specific mechanism of Sema3A regulation marrow mesenchymal stem cells (BMMSCs) during remodelling remains unclear. The tibial denervation model was used and denervated tibia exhibited significantly lower mass as compared to sham operated bones. In vitro, BMMSCs cocultured with dorsal root ganglion (DRGs) or stimulated could promote osteogenic differentiation through...
Human motor planning and control depend highly on optimal feedback systems, such as the neocortex-cerebellum circuit. Here, diffusion tensor imaging was used to verify disruption of circuit in spinocerebellar ataxia type 3 (SCA3), circuit's correlation with SCA3 dysfunction investigated.
Alzheimer's disease is a common neurodegenerative disorder in older adults. Despite its prevalence, pathogenesis remains unclear. In addition to the most widely accepted causes, which include excessive Aβ aggregation, tau hyperphosphorylation, and deficiency of neurotransmitter acetylcholine, numerous studies have shown that dopaminergic system also closely associated with occurrence development this condition. Dopamine crucial catecholaminergic human body. Dopamine-associated treatments,...
Modern pharmacological studies show that Epimedium sagittatum Maxim (EPI) has antioxidant, antiapoptotic, anti-inflammatory effects. However, the effects of EPI on adriamycin-induced nephropathy are unclear.
BACKGROUND: Our previous research proved that vagus nerve stimulation (VNS) improved the neurological outcome after cardiopulmonary resuscitation (CPR) by activating α7 nicotinic acetylcholine receptor (α7nAChR) in a rat model, but underlying mechanism of VNS neuroprotection CPR remains unclear. METHODS:In vivo, we established mouse model cardiac arrest (CA)/CPR to observe survival rate, and changes inflammatory factors brain tissue treatment.In vitro, examined effects α7nAChR agonist on...
The present study investigated the effects of ultrasound (US), a noninvasive technique, on ischemia‑reperfusion injury (IRI) following cardiopulmonary resuscitation (CPR). animals used in were randomized into five groups (n=8 per group) as follows: i) CPR group, where rats underwent 6 min untreated ventricular fibrillation (VF) followed by and defibrillation; ii) US which treatment was identical to group with exception that exposed 24 h prior CPR; iii) MLA α7 nicotinic acetylcholine receptor...
Hongjingtian injection (HJT) is administered in the treatment of vascular diseases, including diabetic angiopathies (DA). However, its underlying mechanisms have not been examined systematically.In this research, we explored potential HJT through network pharmacology. HG-stimulated A7r5 cells served as cell model. Cell proliferation, migration and apoptosis were investigated. The effects on key targets AKT pathway verified by Western blotting experiments with inhibitor LY294002 or activator...
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is an inherited motor disorder that characterized by low body mass index (BMI). Considering the role of hypothalamus in regulating appetitive behaviors and metabolism, BMI may result from hypothalamic degeneration. Objectives To examine volume changes SCA3 comparing patients matched healthy controls to identify potential mediating effects pathology on CAG repeats for BMI. Methods Magnetic resonance imaging datasets volumes 41 49 were...