A5106253148- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
University of Michigan
2024
Immune-surveillance depends in part on the recognition of peptide variants by T cell antigen receptors. Given that both normal B cells and malignant accumulate mutations we chose a murine model multiple myeloma to test conditions induce cell-mediated immunity targeting plasma (PC) clones but sparing PCs. Revealing novel function for intracellular C3d, discovered C3d engaged responses against bone marrow mice had developed spontaneously. Our results show internalized augments immune...
Immune surveillance depends in part on the recognition of peptide variants by T cell antigen receptors. Given that both normal B cells and malignant accumulate mutations we chose a murine model multiple myeloma to test conditions induce cell-mediated immunity targeting plasma (PC) clones but sparing PCs. Revealing previously unknown function for intracellular C3d, found C3d engaged responses against PC bone marrow mice had developed spontaneously. Our results show internalized augments...