A5101737652- Cancer Genomics and Diagnostics
- Reproductive Physiology in Livestock
- Veterinary Medicine and Surgery
- Ovarian cancer diagnosis and treatment
- Noise Effects and Management
- Livestock Management and Performance Improvement
- Cancer Diagnosis and Treatment
- Shoulder Injury and Treatment
- Algal biology and biofuel production
- Bone fractures and treatments
- Photosynthetic Processes and Mechanisms
- Hip and Femur Fractures
- vaccines and immunoinformatics approaches
- Hearing Loss and Rehabilitation
- Body Contouring and Surgery
- Wound Healing and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Genetically Modified Organisms Research
- Photoreceptor and optogenetics research
- Diet and metabolism studies
- CRISPR and Genetic Engineering
- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Molecular Biology Techniques and Applications
- Genetic factors in colorectal cancer
Sardar Vallabhbhai Patel University of Agriculture & Technology
2020-2025
Penn State Milton S. Hershey Medical Center
2023-2024
Pennsylvania State University
2023-2024
Defence Institute of Physiology and Allied Sciences
2019-2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Liechtenstein Institute
2023
Motilal Nehru Medical College
2016-2023
Durham University
2018-2023
Amity University
2018-2022
Massively parallel sequencing approaches are beginning to be used clinically characterize individual patient tumors and select therapies based on the identified mutations. A major question in these analyses is extent which methods identify actionable alterations whether examination of tumor tissue alone sufficient or matched normal DNA should also analyzed accurately tumor-specific (somatic) alterations. To address issues, we comprehensively evaluated 815 tumor-normal paired samples from...
Malignant mixed Müllerian tumours, also known as carcinosarcomas, are rare tumours of gynaecological origin. Here we perform whole-exome analyses 22 using massively parallel sequencing to determine the mutational landscape this tumour type. On average, identify 43 mutations per tumour, excluding four cases with a mutator phenotype that harboured inactivating in mismatch repair genes. In addition TP53 and KRAS, genetic alterations chromatin remodelling genes, ARID1A ARID1B, histone...
A large number of genetically modified (GM) crops, including both food and non-food crops carrying novel traits have been developed released for commercial agriculture production. Soybean, maize, canola cotton the insect resistance herbicide tolerance are main under cultivation worldwide. In addition, many other GM development not yet commercially. Food Agriculture Organization (FAO) in its report, State Security Nutrition World 2017, highlights severity security malnourishment problem most...
We review and analyze the farming (upstream agribusiness supply chain) research literature since 1965 to identify opportunities for operations management (OM) researchers. A majority of reviewed papers in our corpus, until turn 21st century, primarily focus on improving operational efficiency effectiveness using optimization techniques. However, during last two decades, farmers’ welfare interests other stakeholders have drawn OM researchers’ attention. This expanded has become possible due...
Background: Metritis, a common postpartum uterine infection in bovines, poses substantial challenges livestock management, including compromised fertility and economic losses. Poor drug penetration systemic side effects, necessitating innovative localised delivery systems limiting current antibiotic treatments. Aim: This study aimed to develop evaluate the potential effect of ofloxacin-loaded hydrogel as system treat metritis bovine. The focus was on achieving sustained release, enhanced...
Noise, a disturbing and unwanted sound is currently being perceived as widespread environmental stressor. In the present study we investigated activation of oxidative stress mechanism involved in cognitive impairment through changes neuro-inflammation. Sprague Dawley rats (200-220 g m) were exposed to moderate (100dB) pressure level (SPL) noise daily for 2 h s over period 15 30 days consequence on brain regions hippocampus observed behavioral studies by Morris Water Maze assess effects...
Proteolytic enzymes have evolved several mechanisms to cleave peptide bonds. These distinct types been systematically categorized in the MEROPS database. While a BLAST search on these proteases identifies homologous proteins, sequence alignment methods often fail identify relationships arising from convergent evolution, exon shuffling, and modular reuse of catalytic units. We previously established computational method detect functions proteins based spatial electrostatic properties residues...
UVI31+ is an evolutionarily conserved BolA family protein. In this study we examine the presence, localization and possible functions of protein in context a unicellular alga, Chlamydomonas reinhardtii. C. reinhardtii exhibits DNA endonuclease activity induced upon UV stress. Further, that normally localizes to cell wall pyrenoid regions gets redistributed into punctate foci within whole chloroplast, away from pyrenoid, The observed induction UV-stress as well suggests plausible role repair....
<p class="abstract"><strong>Background:</strong> The aim of the present study was to compare result in terms rate union, time ambulation and functional recovery fracture intertrochanteric femur treated by dynamic hip screw (DHS) proximal femoral interlocking nail (PFN) complications implant failure, infection, blood loss C arm exposure both groups.</p><p class="abstract"><strong>Methods:</strong> This a prospective 92 cases, 38 cases were PFN 54 DHS....
Hearing plays a crucial role in the performance of soldier and is important for communication speech processing. Service personnel are constantly exposed to high levels noise hence predisposed occupational health disabilities, principally noise-induced hearing loss (NIHL) tinnitus. NIHL significantly common impairment military can affect warfare performances. Parochial awareness about effects uproarious which exacerbates their hearing, acceptance rate use protection devices follow-up...
Retrorectal cysts are rare congenital anomalies which more common in females. Rarely, malignant transformation can occur these cysts. We report here the case of a middle-aged man who had synchronous presentation adenocarcinoma rectum and squamous cell carcinoma retrorectal cyst. The patient presented with rectal bleeding constipation, underwent abdominoperineal resection complete excision Postoperative histopathological examination showed received adjuvant chemotherapy after 18 months...
This paper presents an inventory model for managing the continuously deteriorating agri–fresh produce in unorganized wholesale market. Replenishment policy is proposed assuming stochastic demand, periodic review and lost sales. Three retrieval options namely first–in–first–out (FIFO), last–in–first–out (LIFO), random (RR) are compared replenishment policy. Considering high problem complexity, artificial immune system (AIS)–based solution methodology applied tested on a new dataset generated...
1529 Background: The anticipated widespread adoption of large scale genomic analyses in precision oncology mandates the development a gene actionability framework. Previous efforts clinical interpretation alterations mainly rely on expert opinion and manual curation primary literature. Furthermore, analytic challenges such as distinguishing somatic -driver- mutations from germline have limited information. Methods: We comprehensively evaluated 815 tumor-normal paired samples 15 tumor types...
The two flexible rod-like flagella (∼500 nm in diameter and 5–15 μm long) of Chlamydomonas reinhardtii, a unicellular green alga, can weakly align molecules an external magnetic field, thereby enabling the measurement various residual dipolar couplings solution NMR spectroscopy.