A5076317743- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Medical Imaging and Analysis
- Spinal Fractures and Fixation Techniques
- Anesthesia and Pain Management
- Cervical and Thoracic Myelopathy
- Pain Mechanisms and Treatments
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Scoliosis diagnosis and treatment
- Shoulder Injury and Treatment
- Myofascial pain diagnosis and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Bone Tissue Engineering Materials
- Sports injuries and prevention
- Traumatic Brain Injury and Neurovascular Disturbances
- Hip and Femur Fractures
- Spinal Hematomas and Complications
- Clinical practice guidelines implementation
- Traumatic Brain Injury Research
- Bone health and osteoporosis research
- Mesenchymal stem cell research
- Blood transfusion and management
- Total Knee Arthroplasty Outcomes
- Tendon Structure and Treatment
University of Gothenburg
2016-2025
Sahlgrenska University Hospital
2016-2025
Western Norway Regional Health Authority
2024
Central Norway Regional Health Authority
2024
Ålesund Hospital
2022
657 Oslo
2022
Uppsala University Hospital
2022
Karolinska Institutet
2022
Karolinska University Hospital
2022
Stavros Niarchos Foundation
2021-2022
Background Sports-related head trauma is common but still there no established laboratory test used in the diagnostics of minimal or mild traumatic brain injuries. Further effects recurrent on injury markers are unknown. The purpose this study was to investigate relationship between Olympic (amateur) boxing and cerebrospinal fluid (CSF) biomarkers. Methods designed as a prospective cohort study. Thirty boxers with minimum 45 bouts 25 non-boxing matched controls were included CSF samples...
In patients with lumbar spinal stenosis and degenerative spondylolisthesis, it is uncertain whether decompression surgery alone noninferior to instrumented fusion.
Studies on fracture incidence have mostly been based retrospectively registered data from local hospital databases. The Swedish Fracture Register (SFR) is a national quality register collecting prospectively fractures, at the time of care-seeking. In present study all different regardless location, in adults' ≥ 16 years treated only care provider for patients with fractures within catchment area approximately 550,000 inhabitants, during 2015‒2018 are described. Age, gender, and location...
In Brief Study Design. Experimental and descriptive study of a xenotransplantation model in minipigs. Objective. To survival function human mesenchymal stem cells (hMSCs) after transplantation into injured porcine spinal discs, as for cell therapy. Summary Background Data. Biologic treatment options the intervertebral disc are suggested patients with chronic low back pain caused by degeneration. Methods. Three lumbar discs each 9 minipigs were aspiration nucleus pulposus (NP), 2 weeks later...
In Brief Study Design. Descriptive experimental study in 4 different mammals. Objective. To investigate cell proliferation/regeneration and localize stem cells/progenitor cells within the intervertebral disc (IVD). Summary of Background Data. Disc degeneration (DD) is believed to play a major role patients with chronic lumbar pain. Lately, biologic treatment options for DD have gained increasing interest. Normal regeneration processes IVD previously been sparsely described therefore it great...
Today, the tool that is most commonly used to evaluate osteogenic differentiation of bone marrow stromal cells (BMSCs) in vitro demonstration expression multiple relevant markers, such as ALP, RUNX2 and OCN. However, yet, there no single surface marker or panel markers which clearly defines human BMSCs (hBMSCs) differentiating towards lineage. The aim this study was therefore examine issue. Stable isotope labeling by amino acids cell culture (SILAC)-based quantitative proteomics utilized...
There is a high prevalence of blood product transfusions in orthopedic surgery. The reported red cell unselected patients undergoing hip or knee replacement varies between 21% and 70%. We determined current loss transfusion total arthroplasty when tranexamic acid was used as routine prophylaxis, further investigated potential predictors for excessive requirement. In total, 193 consecutive unilateral (n = 114) 79) were included prospective observational study. Estimated perioperative...
In Brief Study Design. A prospective study of patients undergoing lumbar disc herniation surgery. Objectives. To assess patients' satisfaction with care/preoperative information, if expectations on surgical results and ability to return work are related baseline characteristics, and/or can predict self-reported outcome. Self-reported outcome was compared objective Summary Background Data. Patients' treatment have been discussed as a predictive factor for postoperative demonstrated be...
Objectives: The aim of this study was to investigate if olympic (amateur) boxing is associated with elevation brain injury biomarkers in peripheral blood compared controls.Materials and methods: Thirty boxers competing at least 47 bouts were 25 controls. Blood collected from the controls one occasion within 1–6 days after a bout rest period 14 days. Tau concentration plasma determined using novel single molecule ELISA assay S-100B, glial fibrillary acidic protein, brain-derived neurotrophic...
Prehabilitation programs have led to improved postoperative outcomes in several surgical contexts, but there are presently no guidelines for the prehabilitation phase before lumbar fusion surgery.
Classification of musculoskeletal pain based on underlying mechanisms (nociceptive, neuropathic, and nociplastic pain) is challenging. In the absence a gold standard, verification features that could aid in discrimination between these clinical practice research depends expert consensus. This Delphi consensus study aimed to: (1) identify assessment findings are unique to mechanism category or shared no more than 2 categories (2) develop ranked list candidate potentially discriminate...
<h3>Importance</h3> Operations for lumbar spinal stenosis is the most often performed surgical procedure in adult spine. This study reports clinical outcome of 3 commonly used minimally invasive posterior decompression techniques. <h3>Objective</h3> To compare effectiveness techniques stenosis. <h3>Design, Setting, and Participants</h3> randomized trial a parallel group design included patients with symptomatic radiologically verified without degenerative spondylolisthesis. Patients were...
Abstract Autologous nucleus pulposus is known to have injurious effects on spinal nerve roots when applied epidurally. Both inflammatory and immunological mechanisms been implicated in this regard. Various proinflammatory substances might be released or activated by affect the endoneural root vessels. The present study assessed pulposus‐induced early vascular reactions possibility of blocking these with intravenous, high‐dose, methylprednisolone pretreatment. In 25 pigs, S2 S3 were exposed....
Descriptive experimental study performed in rabbits of 2 age groups.To and investigate presence prechondrocytic cells cell migration routes (MR) the intervertebral disc (IVD) region to gain knowledge about normal IVD regeneration pattern.Disc degeneration is thought play a major role patients with chronic lumbar pain. Regeneration processes within have been sparsely described. Therefore, it interest increase these order understand pathological conditions IVD.At beginning experiment,...
Low back pain is common and degenerated discs (DDs) are believed to be a major cause. In non-degenerated intervertebral (IVDs) presence of stem/progenitor cells was recently reported in different mammals (rabbit, rat, pig). Understanding processes disc degeneration regenerative mechanisms within DDs important. The aim the study examine local human if these cell populations could respond paracrine stimulation vitro. Tissue biopsies from IVD region (L3-S1) were collected 15 patients, age 34-69...
The aims of this study were to describe the prevalence previous lumbar surgery in patients who undergo total hip arthroplasty (THA) and investigate their patient-reported outcomes (PROMs) one year post-operatively.Data from Swedish Hip Arthroplasty Register Spine gathered between 2002 2012 merged identify a group had undergone before THA (n = 997) carefully matched one-to-one control group. We investigated differences one-year post-operative PROMs groups. Linear regression analyses used...
Reference point indentation is a novel method to assess bone material strength index (BMSi) in vivo. We found that BMSi at the mid-tibia was weakly associated with spine and hip areal mineral density but not prevalent fracture population-based cohort of 211 older women. Lower has been observed patients prior than controls, no association between (aBMD) found. Population-based studies prospective fractures are lacking. hypothesized would be Swedish The aim investigate associations BMSi, aBMD,...
Abstract Mesenchymal stem cells (MSCs) are a candidate for replacing chondrocytes in cell‐based repair of cartilage lesions. However, it has not been clarified if these can acquire the hyaline phenotype, and whether MSCs show same expression patterns critical control genes development. In order to study this, articular iliac crest derived were allowed differentiate pellet mass cultures. Gene markers helix‐loop‐helix (HLH) transcription factors, chondrogenic factors analyzed by real‐time PCR....