A5081269214- Cardiac electrophysiology and arrhythmias
- ECG Monitoring and Analysis
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Ovarian cancer diagnosis and treatment
- EEG and Brain-Computer Interfaces
- Cardiovascular Effects of Exercise
- Neurological disorders and treatments
- Scheduling and Optimization Algorithms
- Heart Rate Variability and Autonomic Control
- Analog and Mixed-Signal Circuit Design
- Cardiomyopathy and Myosin Studies
- Electrical and Bioimpedance Tomography
- Manufacturing Process and Optimization
- Ion channel regulation and function
- Blind Source Separation Techniques
- Cardiovascular Syncope and Autonomic Disorders
- Intraperitoneal and Appendiceal Malignancies
- Product Development and Customization
- Operations Management Techniques
- Non-Invasive Vital Sign Monitoring
Jagiellonian University
2023-2025
University Medical Center Utrecht
2019-2025
Utrecht University
2019-2023
Heidelberg University
2020-2023
University Hospital Heidelberg
2020-2023
AGH University of Krakow
2022
Royal HaskoningDHV (Netherlands)
2019-2022
CRV (Netherlands)
2010-2021
Aalborg University
2020
University of Lucerne
2018-2019
Cross-talk between the estrogen receptor (ER) and phosphoinositide-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathways is a mechanism resistance to endocrine therapy, blockade both enhances antitumor activity in preclinical models. This study explored whether sensitivity letrozole was enhanced with oral mTOR inhibitor, everolimus (RAD001).Two hundred seventy postmenopausal women operable ER-positive breast cancer were randomly assigned receive 4 months neoadjuvant treatment...
Patients with occlusion myocardial infarction (OMI) and no ST-elevation on presenting electrocardiogram (ECG) are increasing in numbers. These patients have a poor prognosis would benefit from immediate reperfusion therapy, but, currently, there accurate tools to identify them during initial triage. Here we report, our knowledge, the first observational cohort study develop machine learning models for ECG diagnosis of OMI. Using 7,313 consecutive multiple clinical sites, derived externally...
The sequences of activation and recovery the heart have physiological clinical relevance. We report on progress made over last years in method that images these timings based an equivalent double layer myocardial surface serving as source cardiac activity, with local transmembrane potentials (TMP) acting their strength. TMP wave forms were described analytically by timing parameters, found minimizing difference between observed body those description. parameter estimation procedure involved...
Left bundle branch block (LBBB) is a critical predictor of patient benefit from cardiac resynchronization therapy (CRT), but recent studies suggest that one-third patients diagnosed with LBBB by conventional electrocardiographic (ECG) criteria may have false-positive diagnosis. In this study, we tested the hypothesis recently proposed strict ECG improve specificity in cases left ventricular hypertrophy (LVH) /dilatation and incomplete LBBB. We developed five heart models based on healthy...
High-resolution digitized cardiac anatomical data sets are in huge demand clinical, basic research and computational settings. They can be leveraged to evaluate intricate structural changes disease pathology, such as myocardial infarction (MI), which is one of the most common causes heart failure death. Advancements high-resolution imaging techniques this field our laboratory have led vast improvements understanding cardiovascular anatomy, especially conduction system (CCS) responsible for...
Computational modeling in electrocardiography often requires the examination of cardiac forward and inverse problems order to non-invasively analyze physiological events that are otherwise inaccessible or unethical explore. The study these models can be performed open-source SCIRun problem solving environment developed at Center for Integrative Biomedical Computing (CIBC). A new toolkit within provides researchers with essential frameworks constructing manipulating electrocardiographic a...
The precise localization of the site origin a premature ventricular contractions (PVC) prior to ablation would facilitate planning and execution electrophysiological procedure. Current electrocardiographic imaging (ECGI) techniques require body surface maps, costly complex procedure, that requires as many 256 leads localize PVC origin. We developed tested novel myocardial activation based ECGI technique utilizing readily available 12-lead ECG major components method are: source model,...
The exponential use of robotic surgery is not the result evidence-based benefits but mainly driven by manufacturers, patients and enthusiastic surgeons. present review literature shows that robot-assisted consistently more expensive than video-laparoscopy in many cases open surgery. average additional variable cost for gynecological procedures was about 1600 USD, rising to 3000 USD when amortized robot itself included. Generally most laparoscopic have less short-term morbidity, blood loss,...
Transgenic mice are frequently used to investigate the role of genes involved in cardiac conduction. The QRS duration calculated from electrocardiogram (ECG) is a commonly measure for ventricular conduction time. However, relation between activation and mouse surface ECG not well understood. We aim relate repolarization patterns with ECG.Ventricular generated by high-density optical mapping six-lead pseudo-ECG were compared isolated hearts. In addition, ECGs simulated silico....
Background Predicting clinical outcomes after cardiac resynchronization therapy (CRT) and its optimization remain a challenge. We sought to determine whether pre- postimplantation QRS area (QRSarea) predict CRT. Methods Results In this retrospective study, QRSarea, derived from vectorcardiography, were assessed in relation the primary end point of mortality CRT with or without defibrillation. Other points included total mortality, heart failure (HF) hospitalization, major adverse events,...
The interpretation of the 12‑lead ECG is notoriously difficult and requires experts to distinguish normal from abnormal waveforms. waveforms depend on body build electrode positions, both often different in males females. To relate cardiac anatomical structures even more difficult. novel CineECG algorithm enables a direct projection anatomy by computing mean location activity over time. aim this study investigate locations derived standard ECGs subjects. In we used 6525 tracings labelled as...
Noninvasive imaging of cardiac activation before ablation the arrhythmogenic substrate can reduce electrophysiological procedure duration and help choosing between an endocardial or epicardial approach. A noninvasive technique was evaluated that estimates both from body surface potential maps. We performed a study in isolated situ pig hearts, estimating maps during sinus rhythm localizing stimulation sites.From 3 Langendorff-perfused 180 intramural unipolar electrograms were recorded ectopic...
Noninvasive reconstruction of cardiac electrical activity has a great potential to support clinical decision making, planning, and treatment. Recently, significant progress been made in the estimation activation from body surface maps (BSPMs) using boundary element method (BEM) with equivalent double layer (EDL) as source model. In this formulation, noninvasive assessment times results nonlinear optimization problem an initial estimate calculated fastest route algorithm (FRA). Each...