A5075990286- Synthesis and biological activity
- Finite Group Theory Research
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Fractional Differential Equations Solutions
- Synthesis of heterocyclic compounds
- Quinazolinone synthesis and applications
- Coding theory and cryptography
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- graph theory and CDMA systems
- Matrix Theory and Algorithms
- Coronary Interventions and Diagnostics
- Numerical methods for differential equations
- Iterative Methods for Nonlinear Equations
- Click Chemistry and Applications
- Differential Equations and Numerical Methods
- Cardiac Imaging and Diagnostics
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Advanced Optimization Algorithms Research
- Cancer therapeutics and mechanisms
- Numerical methods in engineering
- Renal and Vascular Pathologies
- Bioactive Compounds and Antitumor Agents
- Nonlinear Waves and Solitons
Al-Azhar University
2016-2025
Assiut University
2017-2024
National Research Centre
2024
South Valley University
2024
Aswan University
2024
Cairo University
2005-2023
Menoufia University
2014-2023
Al-Azhar University
2020-2023
King Faisal Specialist Hospital & Research Centre
2007-2023
Taif University
2023
Novel quinoline-based derivatives 2a-e and 4a-j have been designed synthesized as potential antiproliferative agents. The compounds were screened for their activity against sixty cell lines according to NCI protocol. promising hybrids 4d-g are by MTT assays on three cancer lines: leukemia (MOLT-4), lung (HOP-92), breast (T47D), with IC50 values ranging from 4.982 ± 0.2 36.52 1.46 µM compared Staurosporine, compound 4e being the most effective. Derivatives evaluated inhibitory EGFR BRAFV600E....
The investigation of novel EGFR and BRAF
The review summarizes recent literatures dealing with hydrazinecarbothioamide group in thiocarbohydrazides and other derivatives including their physical chemical properties along applications the synthesis of heterocycles.
Novel quinoline derivatives carrying nitrones and oxime as nitric oxide donors were prepared characterized using different spectroscopic techniques. Nitrones can release in larger amounts compared to corresponding oximes. Antiproliferative screening results showed that the 2-benzylthioquinoline 6e 6f 2-methylthio analogues 6g 6h exhibited promising antiproliferative activity especially against leukemia colon cancer cell lines. Compounds 6c, 6e, higher potency anticancer agents doxorubicin,...
Dimethyl acetylenedicarboxylate, ethyl propiolate, and E-dibenzoylethylene react with thienopyrimidines (cyclo-pentyl, -hexyl, -heptyl) derivatives to form thiazolo[3,2-a]thieno-[2,3-d]pyrimidin-2-ylidene) acetates, thieno[2,3-d]pyrimidin-2-ylthioacrylates, thieno[2',3':4,5]pyrimido[2,1-b][1,3]thiazin-6-ones, respectively. Reactions proceed via cyclization thio-addition processes. Some of showed high inhibition Hep-G2 cell growth compared the untreated control cells. However, fused heptyl...
Reaction of 3‐aroyl‐1‐arylthioureas with dimethyl but‐2‐ynedioate in dichloromethane and catalyzed by triphenylphosphine at −5°C led to ( Z )‐methyl 2‐[( )‐2‐(4‐aroylimino)‐4‐oxo‐3‐aryl‐1,3‐thiazolidin‐5‐ylidene]acetates good yields. The mechanism is discussed. X‐ray structure analysis one thiazolidine derivative described. Antitumor antioxidant activities have been investigated. One 1,3‐thiazolidine showed moderate antiproliferative vitro activity against hepatocellular carcinoma Hep‐G2,...
The review summarizes recent literatures dealing with the synthetic tools of thieno[2,3-d]pyrimidine derivatives including their biological activities and applications in synthesis heterocycles.