A5053956693- Supramolecular Self-Assembly in Materials
- Supramolecular Chemistry and Complexes
- Luminescence and Fluorescent Materials
- Polydiacetylene-based materials and applications
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- RNA Interference and Gene Delivery
- Mass Spectrometry Techniques and Applications
Johannes Gutenberg University Mainz
2024
Jawaharlal Nehru Centre for Advanced Scientific Research
2021-2024
Materials Science & Engineering
2021
Bioinspired, kinetically controlled seeded growth has been recently shown to provide length, dispersity, and sequence control on the primary structure of dynamic supramolecular polymers. However, command over molecular organization at all hierarchical levels for modulation higher order structures polymers remains a formidable task. In this context, surface-catalyzed secondary nucleation process, which plays an important role in autocatalytic generation amyloid fibrils also during chiral...
Nature employs sophisticated mechanisms to precisely regulate self-assembly and functions within biological systems, exemplified by the formation of cytoskeletal filaments. Various enzymatic reactions auxiliary proteins couple with process, meticulously regulating length resulting macromolecular structures. In this context, we present a bioinspired, reaction-coupled approach for controlled supramolecular polymerization in synthetic systems. To achieve this, employ an reaction that interfaces...
Barcoding provides abilities to learn about individual species within an apparently homogeneous population. We describe a light-mediated multiplexed cellular barcoding strategy through spatial programming of cucurbit[7]uril molecular recognition.
Fluorogenic probes that unmask fluorescence signals in response to bioorthogonal reactions are a powerful new addition biological imaging. They can significantly reduce background and minimize nonspecific signals, potentially enabling real-time, high-contrast imaging without the need wash out excess fluorophores. While diverse classes of highly refined synthetic fluorophores now readily available, integrating them into fluorogenic scheme still requires extensive design efforts customized...
Understanding the mechanism of self-assembly driven by non-covalent interactions is crucial for designing supramolecular materials with desired properties. Here we investigate aromatic peptide amphiphiles, Fmoc-L
Abstract Fluorogenic probes that unmask fluorescence signals in response to a bioorthogonal reaction are powerful new addition biological imaging. They can provide significantly reduced background and minimize non-specific signals, potentially allowing real-time high-contrast imaging without washing out excess fluorophores. While diverse classes of highly refined synthetic fluorophores readily available now, their integration into fluorogenic scheme still necessitates another level extensive...